concept

INTERNEURON

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INTERNEURON: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

448Connections

30Hypotheses

0Analyses

50Outgoing

50Incoming

3Experiments

0Debates

Summary

INTERNEURON is a concept in neurodegeneration research. Key relationships include: associated with, co discussed, targets. Associated with ALS. Connected to 43 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	INTERNEURON
Key Genes/Proteins	AKT, AMYLOID, APP
Related Diseases	acetylcholine, Alzheimer'S Disease, ALZHEIMER'S DISEASE, AUTISM

Pathway Diagram

graph TD
    INTERNEURON["INTERNEURON"]
    INTERNEURON -->|"expressed in"| INTERNEURONS["INTERNEURONS"]
    INTERNEURON -->|"expressed in"| NEURON["NEURON"]
    INTERNEURON -->|"expressed in"| NEURONS["NEURONS"]
    CORTEX["CORTEX"] -->|"regulates"| INTERNEURON
    COMPLEMENT["COMPLEMENT"] -->|"inhibits"| INTERNEURON
    AMYLOID["AMYLOID"] -->|"targets"| INTERNEURON
    APP["APP"] -->|"targets"| INTERNEURON
    GABAERGIC["GABAERGIC"] -->|"targets"| INTERNEURON
    MEF2C["MEF2C"] -->|"expressed in"| INTERNEURON
    MTOR["MTOR"] -->|"expressed in"| INTERNEURON
    FUS["FUS"] -->|"expressed in"| INTERNEURON
    LYSOSOME["LYSOSOME"] -->|"expressed in"| INTERNEURON
    RAB5["RAB5"] -->|"expressed in"| INTERNEURON

Outgoing (96)

Target	Relation	Type	Str
MICROGLIA	contributes_to	cell_type	0.65
OLIGODENDROCYTE	contributes_to	cell_type	0.65
NEURON	associated_with	cell_type	0.65
NEURONS	associated_with	cell_type	0.65
NEURONS	interacts_with	cell_type	0.65
INTERNEURONS	associated_with	cell_type	0.65
THALAMUS	promotes	brain_region	0.60
PYRAMIDAL	regulates	cell_type	0.60
NEURON	interacts_with	cell_type	0.60
T CELL	contributes_to	cell_type	0.60
SYN1	expressed_in	gene	0.60
NEURONS	regulates	cell_type	0.60
INTERNEURONS	targets	cell_type	0.60
NEURON	targets	cell_type	0.60
NEURONS	targets	cell_type	0.60
NEURON	biomarker_for	cell_type	0.60
NEURON	activates	cell_type	0.60
NEURONS	activates	cell_type	0.60
INTERNEURONS	expressed_in	cell_type	0.60
NEURON	expressed_in	cell_type	0.60
NEURONS	expressed_in	cell_type	0.60
INTERNEURONS	causes	cell_type	0.60
NEURON	causes	cell_type	0.60
NEURONS	causes	cell_type	0.60
INTERNEURONS	protects_against	cell_type	0.60
NEURON	protects_against	cell_type	0.60
NEURONS	protects_against	cell_type	0.60
INTERNEURONS	regulates	cell_type	0.60
NEURON	regulates	cell_type	0.60
PREFRONTAL	activates	brain_region	0.60
PREFRONTAL	inhibits	brain_region	0.60
SCHIZOPHRENIA	regulates	disease	0.60
NEURODEGENERATION	biomarker_for	disease	0.60
INTERNEURONS	activates	cell_type	0.60
NEURONS	biomarker_for	cell_type	0.60
SCHIZOPHRENIA	associated_with	disease	0.60
PYRAMIDAL	causes	cell_type	0.60
PYRAMIDAL	expressed_in	cell_type	0.60
NEURON	inhibits	cell_type	0.60
OXIDATIVE STRESS	co_discussed	entity	0.50
T CELL	co_discussed	entity	0.50
MICROGLIA	co_discussed	entity	0.50
OLIGODENDROCYTE	co_discussed	entity	0.50
SCHIZOPHRENIA	co_discussed	entity	0.50
SYNAPSE	co_discussed	entity	0.50
INTERNEURONS	co_discussed	entity	0.50
MITOPHAGY	co_discussed	entity	0.50
NMDA	co_discussed	entity	0.50
TAU	co_discussed	entity	0.50
LRRK2	co_discussed	entity	0.50

Incoming (352)

Source	Relation	Type	Str
GABAERGIC	inhibits	cell_type	0.65
GABAERGIC	biomarker_for	cell_type	0.65
CORTEX	targets	brain_region	0.65
AUTISM	expressed_in	disease	0.65
INS	associated_with	gene	0.60
NEURON	regulates	gene	0.60
TAU	expressed_in	gene	0.60
AGING	therapeutic_target	gene	0.60
CHR2	activates	gene	0.60
APP	therapeutic_target	gene	0.60
PVALB	therapeutic_target	gene	0.60
SST	expressed_in	gene	0.60
SST	regulates	gene	0.60
PVALB	regulates	gene	0.60
BDNF	therapeutic_target	gene	0.60
RAB5	inhibits	gene	0.60
YTHDF1	therapeutic_target	gene	0.60
FUS	therapeutic_target	gene	0.60
LONP1	therapeutic_target	gene	0.60
RAB11	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
EPILEPSY	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
SST	therapeutic_target	gene	0.60
SYNAPSE	therapeutic_target	gene	0.60
SST	associated_with	gene	0.60
GAIN	regulates	gene	0.60
PVALB	expressed_in	gene	0.60
EPILEPSY	associated_with	gene	0.60
ELAVL2	therapeutic_target	gene	0.60
SNAP29	therapeutic_target	gene	0.60
MEF2C	regulates	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
TDP-43	therapeutic_target	gene	0.60
STX17	therapeutic_target	gene	0.60
CORTEX	regulates	brain_region	0.60
APP	targets	gene	0.60
GABAERGIC	targets	cell_type	0.60
CORTEX	activates	brain_region	0.60
GABAERGIC	activates	cell_type	0.60
IGF2BP1	therapeutic_target	gene	0.60
CLPP	therapeutic_target	gene	0.60
AMYLOID	inhibits	gene	0.60
NRG1	associated_with	gene	0.60
AMYLOID	therapeutic_target	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60
RNA	contributes_to	gene	0.60
METTL3	therapeutic_target	gene	0.60
ALS	therapeutic_target	gene	0.60

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop transcranial focused ultrasound targeting EC-II	0.948	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop optogenetic targeting PV interneurons to restore	0.944	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting CA1 PV interneurons	0.927	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.922	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.912	Alzheimer's disease	Circuit-level neural dynamics in neurode

Closed-loop focused ultrasound targeting EC-II SST interneur	0.900	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II SST interneurons to block t	0.896	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.863	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting EC-II PV interneuro	0.863	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.858	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II PV interneurons to suppress	0.857	Alzheimer's disease	Circuit-level neural dynamics in neurode
Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated	0.843	molecular neurobiology	View
Closed-loop tACS targeting EC-II parvalbumin interneurons to	0.831	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.827	Alzheimer's disease	Circuit-level neural dynamics in neurode
Real-time gamma-guided transcranial focused ultrasound targe	0.827	Alzheimer's disease	Circuit-level neural dynamics in neurode
Beta-frequency entrainment therapy targeting PV interneuron-	0.827	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting CA1 PV	0.797	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.784	Alzheimer's disease	Circuit-level neural dynamics in neurode
Prefrontal sensory gating circuit restoration via PV interne	0.775	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.767	Alzheimer's disease	Circuit-level neural dynamics in neurode
C1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV I	0.747	neurodegeneration	Are interneuron oscillation deficits com
BACE1/NRG1 Axis Dysfunction Drives Excitatory/Inhibitory Imb	0.743	neurodegeneration	What are the physiological functions of
Interneuron SYNGAP1 Deficiency Disrupts Cortical Circuit Ass	0.681	neurodevelopment	How does SYNGAP1, a 'synaptic' protein,
Complement C1QA Inhibition Synergizes with PV Interneuron Mo	0.659	neurodegeneration	What molecular mechanisms underlie the d
Parvalbumin Interneuron Vulnerability Links Lactate Transpor	0.656	neurodegeneration	What is the molecular mechanism by which
Optogenetic viral vector delivery via tFUS-mediated blood-br	0.622	Alzheimer's disease	Circuit-level neural dynamics in neurode
Ketone-Based Metabolic Switching to Restore PV Interneuron F	0.609	neurodegeneration	test
Closed-loop transcranial alternating current stimulation to	0.603	Alzheimer's disease	Circuit-level neural dynamics in neurode
Differential Interneuron Optogenetic Restoration Therapy	0.599	neuroscience	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II PV interneurons to enhance	0.596	Alzheimer's disease	Circuit-level neural dynamics in neurode

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (3)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Plant-based dietary patterns and Alzheimer's disease risk in multiethn	clinical	Alzheimer's disease and relate	0.950	human patients	proposed	N/A
SIRPα modulation in mouse models of Alzheimer's disease	validation	Alzheimer's disease	0.900	mouse models of Alzheimer's di	proposed	N/A
Microglial SIRPα expression in human Alzheimer's disease tissue	exploratory	Alzheimer's disease	0.800	human brain tissue	proposed	N/A

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667]	Zhang D, Zhang W, Ming C, Gao X, Yuan H,	Neuron	2024
The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117]	Balusu S, De Strooper B	Acta neuropathologica	2024
Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease. [PMID:34069890]	Burillo J, Marqués P, Jiménez B, Gonzále	Cells	2021
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in tra [PMID:17021169]	["Oakley, Holly", "Cole, Sarah L", "Loga	The Journal of neuroscience :	2006
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road [PMID:12130773]	["Hardy, John", "Selkoe, Dennis J"]	Science (New York, N.Y.)	2002

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning INTERNEURON in their description or question text

INTERNEURON

Understanding Entity Pages

Summary

Pathway Diagram

Outgoing (96)

Incoming (352)

Targeting Hypotheses (30)

Mentioning Analyses (0)

Experiments (3)

Related Papers (5)

Debates (0)

Related Research

Closed-loop focused ultrasound targeting EC-II SST interneurons to restore gamma

Closed-loop tACS targeting EC-II SST interneurons to block tau propagation and r

Optogenetic restoration of hippocampal gamma oscillations via selective PV inter

Closed-loop focused ultrasound targeting EC-II PV interneurons to restore theta-

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Closed-loop tACS targeting EC-II PV interneurons to suppress burst firing and bl

Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated Autophagy Through PV

Closed-loop tACS targeting EC-II parvalbumin interneurons to restore gamma rhyth

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Real-time gamma-guided transcranial focused ultrasound targeting EC-II SST inter

Beta-frequency entrainment therapy targeting PV interneuron-astrocyte coupling f

Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with r

Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activa

Prefrontal sensory gating circuit restoration via PV interneuron enhancement

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla