gene

NUP98

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NUP98: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

27Connections

1Hypotheses

0Analyses

18Outgoing

9Incoming

0Experiments

0Debates

Summary

Page for NUP98 — Nucleoporin 98

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🧬 Gene Info

Gene Symbol	NUP98
Full Name	Nucleoporin 98
Chromosome	11p15.4
Function	peripheral localization: NUP98 contributes to both the central channel barrier and cytoplasmic filament-associated gating
Primary Expression	neurons throughout the central nervous system, with enrichment in the hippocampus, [prefrontal cort
Molecular Weight	40 kDa
Amino Acids	1817 aa
Pathways	ubiquitin-proteasome
UniProt ID	P52948
NCBI Gene ID	4928
Ensembl ID	ENSG00000110713
OMIM	601021
GeneCards	NUP98
Human Protein Atlas	NUP98
FG-hydrogel formation	The GLFG-repeat domain self-assembles into a cohesive hydrogel that fills the central channel, excluding macromolecules larger than ~40 kDa unless chaperoned by transport receptors
Associated Diseases	Alzheimer's Disease, Huntington's Disease
Known Drugs/Compounds	(S)-ACE-OH
Interactions	ACE, AND, CANCER, FLT3, NEURODEGENERATION, Proteins
SciDEX Hypotheses	C9orf72 Hexanucleotide Repeat Dipeptide Repeat Pro
KG Connections	27 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NUP98 — AlphaFold P52948 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NUP98 — Nucleoporin 98

gene · 1381 words

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NUP98 Protein

protein · 1298 words

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Pathway Diagram

flowchart TD
    N0["NUP98"]
    N1["TRIM21"]
    N1 -->|"interacts with"| N0
    N2["Cancer"]
    N0 -->|"activates"| N2
    N3["Neurodegeneration"]
    N0 -->|"activates"| N3
    N0 -->|"degrades"| N3
    N0 -->|"degrades"| N2
    N4["UBIQUITIN"]
    N0 -->|"activates"| N4
    N5["NEURODEGENERATION"]
    N0 -->|"activates"| N5
    N6["AND"]
    N0 -->|"activates"| N6
    N0 -->|"activates"| N1
    N7["ACE"]
    N0 -->|"activates"| N7
    N8["CANCER"]
    N0 -->|"degrades"| N8
    N0 -->|"degrades"| N5
    N9["Raf"]
    N0 -->|"activates"| N9
    N10["Ras"]
    N0 -->|"degrades"| N10

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N2 disease
    class N3 disease
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 gene
    class N9 protein
    class N10 protein

Outgoing (18)

Target	Relation	Type	Str
Neurodegeneration	degrades	disease	0.65
Cancer	degrades	disease	0.65
Neurodegeneration	activates	disease	0.65
Cancer	activates	disease	0.65
NEURODEGENERATION	activates	gene	0.60
ACE	activates	gene	0.60
TRIM21	activates	gene	0.60
CANCER	degrades	gene	0.60
epigenetic regulation	participates_in	pathway	0.60
NEURODEGENERATION	degrades	gene	0.60
UBIQUITIN	activates	gene	0.60
PICALM	regulates	gene	0.60
Raf	activates	protein	0.60
Ras	degrades	protein	0.60
App	degrades	protein	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
AND	activates	gene	0.60
Proteins	activates	protein	0.50

Incoming (9)

Source	Relation	Type	Str
(S)-ACE-OH	interacts_with	compound	0.90
TRIM21	degrades	protein	0.90
NEURODEGENERATION	degrades	gene	0.60
TRIM21	activates	gene	0.60
ACE	activates	gene	0.60
FLT3	activates	gene	0.60
CANCER	activates	gene	0.60
DNA	regulates	gene	0.60
KMT2A	regulates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
C9orf72 Hexanucleotide Repeat Dipeptide Repeat Proteins Inhi	0.738	neurodegeneration	Legacy Pre-Pipeline Hypothesis Import

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NUP98 in their description or question text

No additional research found