gene

TRADD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRADD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

0Hypotheses

0Analyses

11Outgoing

4Incoming

0Experiments

0Debates

Summary

TRADD (TNFRSF1A-Associated via Death Domain) - adaptor protein integrating TNF-α pro-survival and pro-apoptotic signaling in neurodegeneration

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🧬 Gene Info

Gene Symbol	TRADD
Aliases	TNFRSF1A-Associated via Death Domain
Chromosome	16p13.3
Protein Type	Adaptor Protein
Function	encodes a cytosolic adaptor protein with a modular domain architecture enabling multiple protein-protein interactions.
Molecular Weight	34 kDa
Amino Acids	312 aa
Pathways	cascade: **Receptor Act, NF-κB, MAPK, signaling: [@supsup2013], NF-κB pathway
UniProt ID	Q12989
NCBI Gene ID	8717
GeneCards	TRADD
Human Protein Atlas	TRADD
Associated Diseases	Alzheimer's disease, Parkinson's disease, ALS
KG Connections	15 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TRADD — AlphaFold Q12989 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TRADD Gene

gene · 1583 words

→

TRADD Protein

protein · 751 words

→

Pathway Diagram

graph TD
    TRADD["TRADD"]
    TRADD -->|"regulates"| Necroptosis["Necroptosis"]
    TRADD -->|"regulates"| Inflammation["Inflammation"]
    TRADD -->|"regulates"| Apoptosis["Apoptosis"]
    TRADD -->|"regulates"| RIPK1["RIPK1"]
    TRADD -->|"regulates"| INFLAMMATION["INFLAMMATION"]
    TRADD -->|"regulates"| TNFR1["TNFR1"]
    TRADD -->|"regulates"| RIPK3["RIPK3"]
    TRADD -->|"regulates"| AND["AND"]
    RIPK1 -->|"regulates"| TRADD
    APOPTOSIS["APOPTOSIS"] -->|"regulates"| TRADD
    RIPK3 -->|"regulates"| TRADD
    TNFR1 -->|"regulates"| TRADD

Outgoing (11)

Target	Relation	Type	Str
Necroptosis	regulates	disease	0.65
Inflammation	regulates	disease	0.65
INFLAMMATION	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
necroptosis	participates_in	pathway	0.60
necroptosis	regulates	process	0.60
RIPK1	regulates	gene	0.60
TNFR1	regulates	gene	0.60
RIPK3	regulates	gene	0.60
ZBP1	regulates	gene	0.60
Apoptosis	regulates	pathway	0.60

Incoming (4)

Source	Relation	Type	Str
RIPK1	regulates	gene	0.60
RIPK3	regulates	gene	0.60
TNFR1	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TRADD in their description or question text

No additional research found