protein

TNFR2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TNFR2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

181Connections

0Hypotheses

0Analyses

50Outgoing

47Incoming

0Experiments

0Debates

Summary

TNFR2 is a protein involved in neurodegeneration research. Key relationships include: regulates, associated with, expressed in. Associated with ALS, Aging, Als. Connected to 67 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	TNFR2
Aliases	TNFRSF1B Protein
Chromosome	1p36.22
Protein Type	Receptor
Function	is a member of the tumor necrosis factor receptor superfamily.
Primary Expression	Ubiquitous
Molecular Weight	75 kDa
Amino Acids	461 aa
Exons	10
Pathways	NF-κB, PI3K, MAPK
UniProt ID	P20333
NCBI Gene ID	7133
GeneCards	TNFR2
Human Protein Atlas	TNFR2
Associated Diseases	Alzheimer, Inflammation, Ms, Neurodegeneration, Neuroinflammation, Parkinson
Interactions	AGING, ALS, ALZHEIMER, AMYOTROPHIC LATERAL SCLEROSIS, AND, APOPTOSIS
KG Connections	181 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TNFR2 — AlphaFold P20333 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TNFRSF1B Gene

gene · 1700 words

→

TNFR2 (TNFRSF1B Protein)

protein · 883 words

→

Pathway Diagram

graph TD
    TNFR2["TNFR2"]
    ASTROCYTES["ASTROCYTES"]
    TNFR2 -->|"expressed in"| ASTROCYTES
    SYNAPTIC_FUNCTION["SYNAPTIC_FUNCTION"]
    TNFR2 -->|"regulates"| SYNAPTIC_FUNCTION
    SYNAPTIC_PLASTICITY["SYNAPTIC_PLASTICITY"]
    TNFR2 -->|"regulates"| SYNAPTIC_PLASTICITY
    Tumor{"Tumor"}
    TNFR2 -->|"regulates"| Tumor
    Als{"Als"}
    TNFR2 -->|"expressed in"| Als
    Cardiovascular{"Cardiovascular"}
    TNFR2 -->|"inhibits"| Cardiovascular
    TNFR2 -->|"inhibits"| Als
    TNFR2 -->|"inhibits"| Tumor
    Hypertension{"Hypertension"}
    TNFR2 -->|"inhibits"| Hypertension
    Ms{"Ms"}
    TNFR2 -->|"associated with"| Ms
    ALS{"ALS"}
    TNFR2 -->|"expressed in"| ALS
    TNFR1["TNFR1"]
    TNFR2 -->|"expressed in"| TNFR1
    TNF["TNF"]
    TNF -->|"activates"| TNFR2
    GFAP["GFAP"]
    GFAP -->|"regulates"| TNFR2
    TNF -->|"regulates"| TNFR2
    SOD2["SOD2"]
    SOD2 -->|"associated with"| TNFR2
    CAT["CAT"]
    CAT -->|"associated with"| TNFR2
    BAX["BAX"]
    BAX -->|"associated with"| TNFR2
    SPR["SPR"]
    SPR -->|"associated with"| TNFR2
    PPARGC1A["PPARGC1A"]
    PPARGC1A -->|"associated with"| TNFR2
    CASP3["CASP3"]
    CASP3 -->|"associated with"| TNFR2
    PDK1["PDK1"]
    PDK1 -->|"associated with"| TNFR2
    PDK4["PDK4"]
    PDK4 -->|"associated with"| TNFR2
    SOD1["SOD1"]
    SOD1 -->|"associated with"| TNFR2
    style TNFR2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (134)

Target	Relation	Type	Str
neuroinflammation	mediates	process	0.90
anti-inflammatory processes	promotes	process	0.90
tissue protection	promotes	process	0.85
tissue regeneration	promotes	biological_process	0.80
tmTNF	binds_to	protein	0.80
neuroprotection	promotes	biological_process	0.80
Inflammation	regulates	disease	0.75
Tumor	regulates	disease	0.75
SYNAPTIC_FUNCTION	regulates	phenotype	0.72
SYNAPTIC_PLASTICITY	regulates	phenotype	0.72
ASTROCYTES	expressed_in	cell_type	0.72
TNF	regulates	gene	0.70
Aging	regulates	disease	0.65
Als	expressed_in	disease	0.65
Cardiovascular	inhibits	disease	0.65
Als	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Hypertension	inhibits	disease	0.65
Ms	associated_with	disease	0.65
ALS	expressed_in	disease	0.65
Infection	activates	disease	0.65
Rheumatoid Arthritis	activates	disease	0.65
Inflammatory Bowel Disease	activates	disease	0.65
Psoriasis	activates	disease	0.65
Inflammation	activates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cancer	regulates	disease	0.65
Carcinoma	regulates	disease	0.65
Pancreatic Cancer	regulates	disease	0.65
Autoimmune	inhibits	disease	0.65
Rheumatoid Arthritis	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Tumor	causes	disease	0.65
Neurodegeneration	causes	disease	0.65
Parkinson	causes	disease	0.65
Alzheimer	causes	disease	0.65
Neuroinflammation	causes	disease	0.65
Inflammation	causes	disease	0.65
Stroke	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Parkinson	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Als	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Tumor	activates	disease	0.65
Cancer	inhibits	disease	0.65
Als	regulates	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65

Incoming (47)

Source	Relation	Type	Str
TNF-α	binds_to	protein	0.95
TNF	activates	protein	0.72
TNFR1	expressed_in	gene	0.60
TLR3	activates	gene	0.60
ASTROCYTE	expressed_in	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
MICROGLIA	regulates	gene	0.60
ALS	activates	gene	0.60
GFAP	regulates	gene	0.60
TNF	regulates	gene	0.60
TNFR1	interacts_with	gene	0.60
TNFR1	activates	gene	0.60
TNFR1	associated_with	gene	0.60
INFLAMMATION	activates	gene	0.60
INFLAMMATION	regulates	gene	0.60
AND	interacts_with	gene	0.60
AND	activates	gene	0.60
NF-ΚB	activates	gene	0.60
ALS	therapeutic_target	gene	0.60
SOD2	associated_with	gene	0.60
CAT	associated_with	gene	0.60
BAX	associated_with	gene	0.60
SPR	associated_with	gene	0.60
PPARGC1A	associated_with	gene	0.60
CASP3	associated_with	gene	0.60
PDK1	associated_with	gene	0.60
PDK4	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
TNF	expressed_in	entity	0.60
TNFR1	mediates	entity	0.60
FAS	expressed_in	gene	0.60
APOPTOSIS	activates	gene	0.60
AND	inhibits	gene	0.60
AGING	inhibits	gene	0.60
RNA	expressed_in	gene	0.60
AND	regulates	gene	0.60
STROKE	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
PARKINSON	activates	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
STROKE	therapeutic_target	gene	0.60
MICROGLIA	activates	gene	0.60
TNFA	activates	gene	0.55
microglia	activates	cell_type	0.50
NEURON	co_discussed	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TNFR2 in their description or question text

No additional research found