concept

CCR2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CCR2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

107Connections

2Hypotheses

1Analyses

50Outgoing

23Incoming

0Experiments

1Debates

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💡 Concept Info

Name	CCR2
Key Genes/Proteins	AKT, APOE, AQP4, ASC, ASK1, ATF3
Related Pathways	apoptosis pathway, autophagy pathway, blood-brain barrier

Wiki Pages (1)

Knowledge base pages for this entity

CCR2 and CCR5 Antagonists for Neurodegeneration

therapeutic · 844 words

→

Pathway Diagram

graph TD
    CCR2[CCR2]
    CCR2 -->|regulates| peripheral_immune_cell_recruit[peripheral immune cell recruitment]
    CCR2 -->|expressed in| macrophages[macrophages]
    CCR2 -->|regulates| Blood_Brain_Barrier[Blood-Brain Barrier]
    CCR2 -->|involved_in| Pro_Inflammatory_Monocyte_Traf[Pro-Inflammatory Monocyte Trafficking]
    CCR2 -->|regulates| Immune_Cell_Recruitment[Immune Cell Recruitment]
    CCR2 -->|expressed in| microglia[microglia]
    CCR2 -->|promotes| Monocyte_Infiltration[Monocyte Infiltration]
    CCR2 -->|involved_in| cytokine_amplification[cytokine amplification]
    CCR2 -->|activates| blood_brain_barrier[blood brain barrier]
    CCR2 -->|expressed in| CXCR3[CXCR3]
    CCL2[CCL2] -->|binds| CCR2
    CCL3[CCL3] -->|expressed in| CCR2
    CCR1[CCR1] -->|expressed in| CCR2
    AQP4[AQP4] -->|activates| CCR2

Outgoing (84)

Target	Relation	Type	Str
Blood-Brain Barrier	regulates	brain_region	0.90
macrophages	expressed_in	cell_type	0.90
peripheral immune cell recruitment	regulates	process	0.90
Immune Cell Recruitment	regulates	process	0.85
Pro-Inflammatory Monocyte Trafficking	involved_in	process	0.85
microglia	expressed_in	cell_type	0.80
cytokine amplification	involved_in	process	0.75
Monocyte Infiltration	promotes	process	0.75
CX3CR1	associated_with	gene	0.70
Monocyte recruitment	regulates	mechanism	0.70
blood-brain barrier	participates_in	pathway	0.70
NF-kB signaling	participates_in	pathway	0.70
blood brain barrier	activates	cell_type	0.70
oxidative stress response	participates_in	pathway	0.70
CXCR3	expressed_in	gene	0.70
CXCL10	expressed_in	gene	0.60
FGF2	associated_with	gene	0.60
HIF1A	associated_with	gene	0.60
ICAM1	associated_with	gene	0.60
IL13	associated_with	gene	0.60
MRC1	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
CCR5	expressed_in	gene	0.60
PPARG	associated_with	gene	0.60
GFP	associated_with	gene	0.60
ERK	activates	gene	0.60
IFN	activates	gene	0.60
MAPK	activates	gene	0.60
NLR	activates	gene	0.60
RNA	activates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
necroptosis	participates_in	pathway	0.60
glymphatic clearance	participates_in	pathway	0.60
CX3CR1	interacts_with	gene	0.60
CXCL12	interacts_with	gene	0.60
CXCL8	interacts_with	gene	0.60
CXCR1	interacts_with	gene	0.60
CXCR4	interacts_with	gene	0.60
CX3CL1	regulates	gene	0.60
CX3CR1	regulates	gene	0.60
CXCL12	regulates	gene	0.60
CXCR4	regulates	gene	0.60
CD68	associated_with	gene	0.60
P2RY12	associated_with	gene	0.60
neuroinflammation	causes	disease	0.60
CD8	expressed_in	gene	0.60
PD1	expressed_in	gene	0.60
STAT1	phosphorylates	gene	0.60
stroke	inhibits	disease	0.60
neuroinflammation	activates	disease	0.60

Incoming (23)

Source	Relation	Type	Str
CCL2	interacts_with	gene	0.90
CCL2	inhibits	gene	0.90
CCL2	activates	gene	0.90
CCL2	binds	protein	0.90
CCL2	targets	gene	0.80
CCL2	regulates	gene	0.80
CCL2	associated_with	gene	0.80
CCL2	implicated_in	gene	0.70
ASK1	activates	gene	0.60
CCL2	causes	gene	0.60
ASC	activates	gene	0.60
ATF3	activates	gene	0.60
ATG5	activates	gene	0.60
CCL2	expressed_in	gene	0.60
CCL2	phosphorylates	gene	0.60
AQP4	activates	gene	0.60
CCL2	cleaves	gene	0.60
AQP4	inhibits	gene	0.60
AKT	activates	gene	0.60
CCL3	expressed_in	gene	0.60
CCR1	expressed_in	gene	0.60
APOE	associated_with	gene	0.60
CASP1	associated_with	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Peripheral Monocyte/Macrophage Infiltration Mimicking Microg	0.693	neuroinflammation	What causes IBA1 low/negative microglia
Microglial Replacement and Ontogeny Shift	0.580	developmental neurobiology	Do perinatal immune challenges create pe

Mentioning Analyses (1)

Scientific analyses that reference this entity

Do bacterial curli amyloids cross the blood-brain barrier to directly seed α-syn

neurodegeneration | 2026-04-12 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Do bacterial curli amyloids cross the blood-brain barrier to directly seed α-syn

closed · Rounds: 4 · Score: 0.84 · 2026-04-12