gene

PILRA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PILRA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

81Connections

0Hypotheses

0Analyses

44Outgoing

37Incoming

0Experiments

0Debates

Summary

Paired Immunoglobulin-Like Type 2 Receptor Alpha - immune receptor in neuroinflammation and neurodegeneration

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🧬 Gene Info

Gene Symbol	PILRA
Full Name	Paired Immunoglobulin-Like Type 2 Receptor Alpha
Chromosome	7q22.1
Protein Family	Paired immunoglobulin-like receptor family
Protein Type	Receptor
Function	is an inhibitory immune receptor expressed primarily on cells of the immune system.
Molecular Weight	31 kDa
Amino Acids	279 aa
UniProt ID	Q9YH5Q
NCBI Gene ID	9317
Ensembl ID	ENSG00000137216
OMIM	604866
GeneCards	PILRA
Human Protein Atlas	PILRA
Associated Diseases	Als, Alzheimer, Alzheimer's disease, Atherosclerosis, Macular Degeneration
Interactions	ABCA7, APOE, BIN1, MAF, PILRB, SORL1
KG Connections	81 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PILRA — AlphaFold Q9YH5Q Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PILRA Gene

gene · 2811 words

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PILRA Protein

protein · 1248 words

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Pathway Diagram

graph TD
    PILRA["PILRA"]
    Alzheimer{"Alzheimer"}
    PILRA -->|"therapeutic target"| Alzheimer
    Aging{"Aging"}
    PILRA -->|"therapeutic target"| Aging
    Ms{"Ms"}
    PILRA -->|"therapeutic target"| Ms
    IDUA["IDUA"]
    PILRA -->|"therapeutic target"| IDUA
    TAU["TAU"]
    PILRA -->|"therapeutic target"| TAU
    GRN["GRN"]
    PILRA -->|"therapeutic target"| GRN
    neurodegeneration["neurodegeneration"]
    PILRA -->|"implicated in"| neurodegeneration
    ACE["ACE"]
    ACE -->|"therapeutic target"| PILRA
    TREM2["TREM2"]
    TREM2 -->|"therapeutic target"| PILRA
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"therapeutic target"| PILRA
    style PILRA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (44)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:PILRA	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
ds-f50762b67605	provides_data_for	dataset	1.00
Alzheimer'S Disease	therapeutic_target	disease	0.85
Alzheimer's Disease	therapeutic_target	disease	0.85
Ms	therapeutic_target	disease	0.65
Macular Degeneration	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
TNF	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
ZCWPW1	associated_with	gene	0.60
MAF	associated_with	gene	0.60
ABCA7	associated_with	gene	0.60
RIN3	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
SPI1	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
App	associated_with	protein	0.60
Alzheimer's disease	causes	disease	0.60
Parkinson's disease	causes	disease	0.60
ALS	causes	disease	0.60
Alzheimer's disease	regulates	disease	0.60
neurodegeneration	causes	disease	0.60
PILRB	interacts_with	gene	0.60
SORL1	interacts_with	gene	0.60
PILRB	regulates	gene	0.60
RET	regulates	gene	0.60
TREM2	regulates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
SHARPIN	causes	gene	0.60
STX6	causes	gene	0.60
TREM2	causes	gene	0.60
Endocytosis	associated_with	pathway	0.60
TAU	therapeutic_target	gene	0.60
GRN	therapeutic_target	gene	0.60
IDUA	therapeutic_target	gene	0.60
TNF	co_expressed_with	gene	0.50
ZCWPW1	interacts_with	gene	0.50
ZCWPW1	co_mentioned	gene	0.40

Incoming (37)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:PILRA	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
ds-f50762b67605	data_in	dataset	1.00
GENES	associated_with	gene	0.60
ALZHEIMER DISEASE	associated_with	gene	0.60
ACE	therapeutic_target	gene	0.60
AND	associated_with	gene	0.60
B4GALNT1	causes	gene	0.60
ALZHEIMER	associated_with	gene	0.60
TREM2	therapeutic_target	gene	0.60
MAF	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
MAF	associated_with	gene	0.60
ZCWPW1	associated_with	gene	0.60
ABCA7	associated_with	gene	0.60
ATXN3	causes	gene	0.60
BST1	causes	gene	0.60
CR2	causes	gene	0.60
TNF	associated_with	gene	0.60
GPNMB	causes	gene	0.60
IL34	causes	gene	0.60
CD33	regulates	gene	0.60
CD55	regulates	gene	0.60
EPHA1	regulates	gene	0.60
ERBB1	causes	gene	0.60
BIN1	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
APOE	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
CD2AP	associated_with	gene	0.60
CD33	associated_with	gene	0.60
CLU	associated_with	gene	0.60
CR1	associated_with	gene	0.60
PICALM	associated_with	gene	0.60
LXR	co_expressed_with	protein	0.50
ABCA7	interacts_with	gene	0.50
MAF	co_mentioned	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PILRA in their description or question text

No additional research found