concept

COMPLEMENT ACTIVATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about COMPLEMENT ACTIVATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

72Connections

2Hypotheses

3Analyses

47Outgoing

25Incoming

0Experiments

3Debates

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💡 Concept Info

Name	COMPLEMENT ACTIVATION
Key Genes/Proteins	ALPHA-SYNUCLEIN, AMYLOID, COMPLEMENT, INFLAMMASOME
Related Diseases	ALZHEIMER'S DISEASE, INFLAMMATION
Related Pathways	COMPLEMENT CASCADE

Pathway Diagram

graph TD
    COMPLEMENT_ACTIVATION["COMPLEMENT ACTIVATION"]
    COMPLEMENT_ACTIVATION -->|"causes"| Retinal_Ganglion_Cell_Dysfunct["Retinal Ganglion Cell Dysfunction"]
    COMPLEMENT_ACTIVATION -->|"causes"| Brain_Inflammation["Brain Inflammation"]
    COMPLEMENT_ACTIVATION -->|"activates"| MICROGLIA["MICROGLIA"]
    COMPLEMENT_ACTIVATION -->|"promotes"| Neurodegeneration["Neurodegeneration"]
    COMPLEMENT_ACTIVATION -->|"mediates"| Tissue_Destruction["Tissue Destruction"]
    COMPLEMENT_ACTIVATION -->|"contributes to"| Alzheimer_s_Disease["Alzheimer's Disease"]
    NPTX2["NPTX2"] -->|"inhibits"| COMPLEMENT_ACTIVATION
    Microglia["Microglia"] -->|"upregulates"| COMPLEMENT_ACTIVATION
    C1Q["C1Q"] -->|"activates"| COMPLEMENT_ACTIVATION
    C1QA["C1QA"] -->|"regulates"| COMPLEMENT_ACTIVATION
    Progranulin["Progranulin"] -->|"regulates"| COMPLEMENT_ACTIVATION
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| COMPLEMENT_ACTIVATION
    ASTROCYTES["ASTROCYTES"] -->|"activates"| COMPLEMENT_ACTIVATION
    COMPLEMENT["COMPLEMENT"] -->|"activates"| COMPLEMENT_ACTIVATION

Outgoing (47)

Target	Relation	Type	Str
Brain Inflammation	promotes	process	0.95
MICROGLIA	activates	cell_type	0.95
Brain Inflammation	causes	process	0.95
Retinal Ganglion Cell Dysfunction	causes	phenotype	0.95
Neurodegeneration	promotes	process	0.95
Neuromyelitis Optica Spectrum Disorder	drives	disease	0.90
Alzheimer's Disease	contributes_to	disease	0.90
Alzheimer's disease	involved_in	disease	0.90
Tissue Destruction	mediates	mechanism	0.90
Tissue Destruction	causes	process	0.90
Retinal Ganglion Cell Death	causes	phenotype	0.90
SYNAPTIC LOSS	contributes_to	entity	0.85
Schizophrenia	contributes_to	disease	0.85
Neuroinflammation	associated_with	process	0.85
Synaptic Loss	contributes_to	phenotype	0.80
ALZHEIMER'S DISEASE	biomarker_for	disease	0.80
Alzheimer's disease	drives	disease	0.80
Vascular Dysfunction	contributes_to	phenotype	0.80
neurodegeneration	causes	process	0.80
Cerebral Amyloid Angiopathy	involved_in	disease	0.75
synapse elimination	causes (excessive complement activation leads to neurotoxi)	mechanism	0.75
Cerebral Amyloid Angiopathy	contributes_to	disease	0.75
neuroinflammation	drives	mechanism	0.70
synapse loss	causes	process	0.70
SYNAPTIC LOSS	causes	phenotype	0.70
NEURONS	exacerbates	cell_type	0.70
AMYLOID	causes	protein	0.70
synaptic pruning	activates	process	0.70
INFLAMMATION	causes	phenotype	0.65
INFLAMMATION	implicated_in	phenotype	0.55
PHAGOCYTOSIS	activates	process	0.50
CORTEX	associated_with	brain_region	0.50
AMYLOID PET	associated_with	biomarker	0.50
COMPLEMENT CASCADE	associated_with	pathway	0.50
NLRP3 INFLAMMASOME	associated_with	pathway	0.45
CHOROID PLEXUS	associated_with	brain_region	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
RETINA	associated_with	brain_region	0.45
NEURON	activates	cell_type	0.35
MACROPHAGES	activates	cell_type	0.35
INFLAMMATION	activates	process	0.35
CORTEX	activates	brain_region	0.35
OXIDATIVE STRESS	activates	process	0.35
TREM2	activates	gene	0.35
INFLAMMASOME	activates	protein	0.35
NEURODEGENERATION	activates	process	0.35
NEUROINFLAMMATION	activates	process	0.35

Incoming (25)

Source	Relation	Type	Str
NPTX2	inhibits	protein	0.95
Microglia	associated_with	cell_type	0.85
MICROGLIA APOE LIPOPROTEINS	involved_in	protein	0.85
Microglia	upregulates	cell_type	0.85
TREM2	upregulates	gene	0.85
Amyloid Plaques	associated_with	biomarker	0.80
SPI1	associated_with	gene	0.80
APOE	modulates	gene	0.70
C5AR1	mediates	gene	0.70
MICROGLIA	inhibits	cell_type	0.70
C1Q	activates	protein	0.70
C1QA	regulates	gene	0.70
TREM2	inhibits	gene	0.65
TREM2	regulates	gene	0.65
TREM2	interacts_with	gene	0.65
MICROGLIA	degrades	cell_type	0.65
SPI1	interacts_with	gene	0.65
MICROGLIA	interacts_with	cell_type	0.65
INFLAMMATION	targets	phenotype	0.65
Progranulin	regulates	protein	0.60
ALZHEIMER'S DISEASE	activates	disease	0.50
COMPLEMENT	activates	protein	0.50
ASTROCYTES	activates	cell_type	0.50
ALPHA-SYNUCLEIN	activates	gene	0.35
ANGIOGENESIS	activates	process	0.35

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SUMO1-Mediated Synaptotagmin-1 SUMOylation at Lys124 Impairs	0.652	neurodegeneration	What are the specific PTM changes in syn
Direct C1q Binding Enables FcγR-Independent Complement Activ	0.138	molecular biology	Does Alectinib truly bind C1q directly w