gene

APH1B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about APH1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

102Connections

0Hypotheses

0Analyses

50Outgoing

35Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	APH1B
Full Name	Aph-1 Homolog B, Gamma-Secretase Subunit
Aliases	APH-1B
Chromosome	15q22.2
Function	Gamma-secretase complex subunit, cleaves APP and Notch
Subcellular Localization	Substrate Processing: Contributes to the recognition and processing of various type I transmembrane protein substrat
Molecular Weight	28.5 kDa
Amino Acids	257
Pathways	Gamma-secretase complex, Notch signaling, APP processing
UniProt ID	Q8WW43
NCBI Gene ID	83464
Ensembl ID	ENSG00000138613
OMIM	607630
GeneCards	APH1B
Human Protein Atlas	APH1B
Associated Diseases	AD, Als, Alzheimer, Alzheimer's disease, AMI, disease
Interactions	A2M, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APH1A
KG Connections	102 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: APH1B — AlphaFold Q8WW43 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

APH1B Gene - Anterior Pharynx Defective 1 Homolog B

gene · 790 words

→

APH1B Protein - Anterior Pharynx Defective 1 Homolog B

protein · 717 words

→

Pathway Diagram

graph TD
    APH1B["APH1B"] -->|"interacts"| Alzheimer["Alzheimer"]
    style Alzheimer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    APH1B["APH1B"] -->|"interacts"| Tumor["Tumor"]
    style Tumor fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    APH1B["APH1B"] -->|"interacts"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    APH1B["APH1B"] -->|"interacts"| APOE["APOE"]
    style APOE fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    APH1B["APH1B"] -->|"interacts"| IL6["IL6"]
    style IL6 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    APH1B["APH1B"] -->|"interacts"| SREBF1["SREBF1"]
    style SREBF1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    APH1B["APH1B"] -->|"interacts"| PSEN2["PSEN2"]
    style PSEN2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    NCSTN["NCSTN"] -->|"interacts"| APH1B["APH1B"]
    style NCSTN fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    FAS["FAS"] -->|"interacts"| APH1B["APH1B"]
    style FAS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    TNF["TNF"] -->|"interacts"| APH1B["APH1B"]
    style TNF fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    LMNA["LMNA"] -->|"interacts"| APH1B["APH1B"]
    style LMNA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    DHCR24["DHCR24"] -->|"interacts"| APH1B["APH1B"]
    style DHCR24 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style APH1B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (67)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:APH1B	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
ALS	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
GENES	interacts_with	gene	0.60
Apoptosis	interacts_with	pathway	0.60
Cholesterol	interacts_with	pathway	0.60
ALZHEIMER	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
Raf	interacts_with	protein	0.60
Alzheimer's disease	interacts_with	disease	0.60
NCSTN	interacts_with	gene	0.60
Dynein	interacts_with	protein	0.60
Kinesin	interacts_with	protein	0.60
APP	regulates	gene	0.60
BACE1	regulates	gene	0.60
BACE2	regulates	gene	0.60
NCSTN	regulates	gene	0.60
PEN2	regulates	gene	0.60
PSEN1	regulates	gene	0.60
AND	interacts_with	gene	0.60
PSEN2	regulates	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
FAS	interacts_with	gene	0.60
DYNEIN	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
TFCP2	interacts_with	gene	0.60
AMYLOID	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
IL6	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60
PSEN2	interacts_with	gene	0.60
A2M	interacts_with	gene	0.60
DHCR24	interacts_with	gene	0.60
HMGCR	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
PARP1	interacts_with	gene	0.60
PEN2	interacts_with	gene	0.60
PSEN1	interacts_with	gene	0.60
DAPK1	interacts_with	gene	0.60
HSPG2	interacts_with	gene	0.60
IL1B	interacts_with	gene	0.60
APP	interacts_with	gene	0.60
EIF2AK2	interacts_with	gene	0.60
PSEN1	inhibits	gene	0.60
PSEN2	inhibits	gene	0.60

Incoming (35)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:APH1B	data_in	dataset_row	0.00
genes-aph1b	linked_to	wiki_page	1.00
ds-83b31ef18d49	data_in	dataset	1.00
DYNEIN	interacts_with	gene	0.60
PSEN1	interacts_with	gene	0.60
ADAM10	associated_with	gene	0.60
DHCR24	interacts_with	gene	0.60
EIF2AK2	interacts_with	gene	0.60
IL1B	interacts_with	gene	0.60
DAPK1	interacts_with	gene	0.60
HMGCR	interacts_with	gene	0.60
PARP1	interacts_with	gene	0.60
HSPG2	interacts_with	gene	0.60
PSEN2	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
A2M	interacts_with	gene	0.60
APP	interacts_with	gene	0.60
IL6	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
PEN2	interacts_with	gene	0.60
ADAM10	regulates	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
AMYLOID	interacts_with	gene	0.60
FAS	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
APH1A	inhibits	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
NCSTN	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
TFCP2	interacts_with	gene	0.60
MITOCHONDRIAL DNA	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning APH1B in their description or question text

No additional research found