Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about chromatin_accessibility: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| SPI1 | modulates | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Chromatin Accessibility Restoration via BRD4 Modulation | 0.768 | neurodegeneration | Epigenetic reprogramming in aging neuron |
Scientific analyses that reference this entity
neuroinflammation | 2026-04-08 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Cognitive Reserve Mechanisms in Alzheimer's Disease — Molecular Basis | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Epigenetic Dysregulation in Huntington's Disease — Therapeutic Targeti | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $3,000,000 |
| Epigenetic Dysregulation Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
| Epigenetic Regulation Dysfunction in Alzheimer's and Parkinson's Disea | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Sertad4 Regulates Pathological Cardiac Remodeling. [PMID:41889836] | Francois A, Bermeo-Blanco O, Nguyen BT, | bioRxiv : the preprint server | 2026 | 0 |
| Hsp70-Targeting Chimeras Enable Dual Proteasomal and Lysosomal Degradation of In [PMID:41874277] | Wang Z, Li P, Yin F, Zhang H, Wang S, Te | Journal of medicinal chemistry | 2026 | 0 |
| Cartilage targeting hydrogel nanoplatform degrades BRD4 to alleviate osteoarthri [PMID:41904167] | Zhao Q, Xu T, Du Z, Lu X, Zhang Y, Peng | Nature communications | 2026 | 0 |
| Molecular insights for the tumor suppressor role of SPOP in prostate cancer. [PMID:41707797] | Yan P, Xue X, Hou T, Wang J, Jiang W et | Biochim Biophys Acta Rev Cance | 2026 | 0 |
| Nutrient-driven histone acetylation underlies energy storage and mobilization. [PMID:41786244] | Chen L, Zhu L, Xiao H, Wang X, Xia F et | Mol Metab | 2026 | 0 |
| Alkyne Two-Phase Strategy: Rapid Generation of TK-285-Derived PROTACs as BRD4 De [PMID:41852276] | Yamakoshi H, Watanabe R, Segawa R, Ishih | Journal of medicinal chemistry | 2026 | 0 |
| The epigenetic and epitranscriptomic regulation of Brd4-Mettl3 axis on STING med [PMID:41917296] | Zhao J, Luo X, Wang Z, Luo W, Wu S, Ma X | Inflammation research : offici | 2026 | 0 |
| Punicalagin with anti-inflammatory activities affects Brd-4 mediated chromatin r [PMID:41807492] | Li H, Li Q, Wan T, Wang Y, Zhang S | Scientific reports | 2026 | 0 |
| Targeting BRD4-A Promising Therapeutic Option for Glioblastoma? [PMID:41828493] | Lindner M, Lisińska D, Kędzierzyńska A, | International journal of molec | 2026 | 0 |
| High-intensity interval training alleviates COPD-induced gastrocnemius muscle dy [PMID:41865095] | Zhu C, Peng W, Yang L, Zhang W | Journal of muscle research and | 2026 | 0 |
| A photothermal immune hydrogel dressing for enhanced post-melanoma resection tre [PMID:41877232] | Tan D, Zhu W, Liu S, Liao F, Xu X, Luo J | Journal of nanobiotechnology | 2026 | 0 |
| Recovery of FAM134A-mediated ER-phagy through BRD4 inhibition alleviates ethanol [PMID:40959274] | ["Lim J", "Chae C", "Yoon J", "Cho J", " | International journal of biolo | 2025 | 0 |
| A human Tau expressing zebrafish model of progressive supranuclear palsy identif [PMID:39294122] | ["Bai Q", "Shao E", "Ma D", "Jiao B", "S | Nature communications | 2024 | 0 |
| Targeted Protein O-GlcNAcylation Using Bifunctional Small Molecules. [PMID:38561350] | ["Ma B", "Khan K", "Xu T", "Xeque Amada | Journal of the American Chemic | 2024 | 0 |
| Chem-CRISPR/dCas9FCPF: a platform for chemically induced epigenome editing. [PMID:39315698] | ["Altinbay M", "Wang J", "Chen J", "Sch\ | Nucleic acids research | 2024 | 0 |
| Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic [PMID:38643236] | ["Rosenthal Z", "Fass D", "Payne N", "Sh | Scientific reports | 2024 | 0 |
| A novel PROTAC molecule dBET1 alleviates pathogenesis of experimental autoimmune [PMID:39002520] | ["Song Z", "Li J", "He Y", "Wang X", "Ti | International immunopharmacolo | 2024 | 0 |
| Bromodomain-containing protein 4 (BRD4): a key player in inflammatory bowel dise [PMID:36710583] | ["Ma Z", "Bolinger A", "Zhou J", "Tian B | Expert opinion on therapeutic | 2023 | 0 |
| Genetic and epigenetic regulators of retinal Müller glial cell reprogramming. [PMID:37846362] | ["Xiao X", "Liao Z", "Zou J"] | Advances in ophthalmology prac | 2023 | 0 |
| Bromodomain and Extra-Terminal Proteins in Brain Physiology and Pathology: BET-i [PMID:36979729] | ["Martella N", "Pensabene D", "Varone M" | Biomedicines | 2023 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning chromatin_accessibility in their description or question text
No additional research found