gene

TMEM106B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TMEM106B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

383Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

Summary

TMEM106B is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, interacts with. Associated with Aging, Als, Alzheimer. Connected to 27 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TMEM106B
Aliases	Transmembrane Protein 106B
Chromosome	7p21.3
Protein Family	Type II lysosomal transmembrane protein family
Function	is a 323-amino acid type II lysosomal transmembrane protein encoded by the TMEM106B gene on chromosome 7p21.
Primary Expression	Late endosomes and lysosomes
Molecular Weight	30.3 kDa
Amino Acids	274 aa
Exons	9
Pathways	Autophagy, endosome-lysosome function
UniProt ID	Q9NUM4
GeneCards	TMEM106B
Human Protein Atlas	TMEM106B
Molecular weight	Approximately 31 kDa
Topology	Type II transmembrane protein (N-out, C-in)
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease
Interactions	Actin, ALZHEIMER, ALZHEIMER DISEASE, AMYLOID, AND, APOE
KG Connections	383 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: TMEM106B — AlphaFold Q9NUM4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

TMEM106B Haplotype as Genetic Modifier in FTD — Mechanism and Therapeutic Exploitation

experiment · 641 words

→

TMEM106B Lysosomal Restoration Therapy for Neurodegeneration

general · 608 words

→

Pathway Diagram

graph TD
    TMEM106B["TMEM106B"]
    endosome_lysosome_function(["endosome-lysosome function"])
    TMEM106B -->|"regulates"| endosome_lysosome_function
    Alzheimer{"Alzheimer"}
    TMEM106B -->|"associated with"| Alzheimer
    TMEM106B -->|"therapeutic target"| Alzheimer
    Ms{"Ms"}
    TMEM106B -->|"therapeutic target"| Ms
    Dementia{"Dementia"}
    TMEM106B -->|"therapeutic target"| Dementia
    Als{"Als"}
    TMEM106B -->|"therapeutic target"| Als
    TMEM106B -->|"associated with"| Als
    Aging{"Aging"}
    TMEM106B -->|"associated with"| Aging
    TMEM106B -->|"interacts with"| Dementia
    SIGLEC9["SIGLEC9"]
    TMEM106B -->|"associated with"| SIGLEC9
    SIRPA["SIRPA"]
    TMEM106B -->|"associated with"| SIRPA
    GRN["GRN"]
    TMEM106B -->|"associated with"| GRN
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"associated with"| TMEM106B
    TREM2["TREM2"]
    TREM2 -->|"associated with"| TMEM106B
    ALZHEIMER_S_DISEASE -->|"therapeutic target"| TMEM106B
    CTSH["CTSH"]
    CTSH -->|"associated with"| TMEM106B
    FTLD["FTLD"]
    FTLD -->|"associated with"| TMEM106B
    MAPT["MAPT"]
    MAPT -->|"associated with"| TMEM106B
    style TMEM106B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (209)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:TMEM106B	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Cell Subtype Proportion	regulates	phenotype	0.90
oxidative stress response	participates_in	pathway	0.80
endosome-lysosome function	regulates	pathway	0.70
lipid metabolism	participates_in	pathway	0.70
TDP-43 pathology	regulates	process	0.70
lysosomal function	modulates	process	0.70
neurodegeneration	associated_with	process	0.70
Neurodegeneration	regulates	disease	0.65
Cerebral Amyloid Angiopathy	expressed_in	disease	0.65
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Dementia	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Alzheimer	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Alzheimer	activates	disease	0.65
Aging	causes	disease	0.65
Ms	biomarker_for	disease	0.65
Ftd	associated_with	disease	0.65
Frontotemporal Dementia	biomarker_for	disease	0.65
Dementia	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Aging	biomarker_for	disease	0.65
Schizophrenia	biomarker_for	disease	0.65
Amyotrophic Lateral Sclerosis	biomarker_for	disease	0.65
ALS	expressed_in	disease	0.65
Ms	causes	disease	0.65
Frontotemporal Dementia	causes	disease	0.65
AUTOPHAGY	associated_with	phenotype	0.65
Neurodegeneration	causes	disease	0.65
Dementia	causes	disease	0.65
Als	causes	disease	0.65
Alzheimer	causes	disease	0.65
Parkinson	causes	disease	0.65
Amyotrophic Lateral Sclerosis	causes	disease	0.65
Ftd	causes	disease	0.65
FRONTOTEMPORAL DEMENTIA	increases_risk	disease	0.65
DEMENTIA	increases_risk	disease	0.65
FRONTOTEMPORAL DEMENTIA	regulates	disease	0.65
LYSOSOMAL DYSFUNCTION	inhibits	phenotype	0.65
FRONTOTEMPORAL DEMENTIA	treats	disease	0.65
OLIGODENDROCYTE	degrades	cell_type	0.65
DEMYELINATION	activates	phenotype	0.65
AUTOPHAGY	inhibits	phenotype	0.65
AUTOPHAGY	treats	phenotype	0.65
AGING	increases_risk	phenotype	0.65

Incoming (174)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:TMEM106B	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
ALZHEIMER DISEASE	associated_with	gene	0.80
DEMENTIA	inhibits	disease	0.65
C9orf72	interacts_with	gene	0.65
GAUCHER DISEASE	activates	disease	0.65
PTK2B	inhibits	gene	0.60
FTLD	associated_with	gene	0.60
ALS	regulates	gene	0.60
NEURODEGENERATIVE DISORDERS	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
ALS	associated_with	gene	0.60
AND	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	causes	gene	0.60
AUTOPHAGY	causes	gene	0.60
AMYLOID	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60
MICROGLIA	expressed_in	gene	0.60
PARKINSON	expressed_in	gene	0.60
SIGLEC9	associated_with	gene	0.60
AND	expressed_in	gene	0.60
GRN	inhibits	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
DNA	interacts_with	gene	0.60
ALS	co_expressed_with	gene	0.60
TREM2	associated_with	gene	0.60
TAR	interacts_with	gene	0.60
NEURODEGENERATIVE DISORDERS	causes	gene	0.60
AND	causes	gene	0.60
GENES	causes	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	biomarker_for	gene	0.60
APOE	interacts_with	gene	0.60
GRN	protects_against	gene	0.60
GRN	biomarker_for	gene	0.60
GRN	interacts_with	gene	0.60
SORL1	interacts_with	gene	0.60
CHMP2B	causes	gene	0.60
ANXA11	causes	gene	0.60
CCNF	causes	gene	0.60
CHCHD10	causes	gene	0.60
CHCHD2	causes	gene	0.60
CYLD	causes	gene	0.60
FUS	causes	gene	0.60
GRN	causes	gene	0.60
MAPT	causes	gene	0.60
OPTN	causes	gene	0.60
PRNP	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
TMEM106B Haplotype as Genetic Modifier in FTD — Mechanism and Therapeu	validation	Neurodegeneration	0.400	0.50	human	proposed	$2,730,000

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TMEM106B in their description or question text

No additional research found

TMEM106B

Understanding Entity Pages

Summary

Wiki Pages (6)

TMEM106B

TMEM106B — Transmembrane Protein 106B

TMEM106B Protein (Transmembrane Protein 106B)

TMEM106B Genetic Modifiers in FTD

TMEM106B Haplotype as Genetic Modifier in FTD — Mechanism and Therapeutic Exploitation

TMEM106B Lysosomal Restoration Therapy for Neurodegeneration

Pathway Diagram

Outgoing (209)

Incoming (174)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Experiments (1)

Related Papers (0)

Debates (0)

Related Research