protein

PU.1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PU.1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

20Connections

2Hypotheses

1Analyses

12Outgoing

8Incoming

0Experiments

1Debates

Summary

PU.1 transcription factor - microglial master regulator

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🔬 Protein Info

Gene Symbol	PU.1
Aliases	PU.1 transcription factor
Molecular Weight	31 kDa
Pathways	Cholesterol
Interactions	IL-10, MAPK, MERTK
KG Connections	20 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

SPI1 Gene - PU.1

gene · 2569 words

→

PU.1 Protein (SPI1)

protein · 878 words

→

Pathway Diagram

graph TD
    PU_1["PU.1"]
    PU_1 -->|"regulates"| Macrophage_Polarization["Macrophage Polarization"]
    PU_1 -->|"activates"| apoptosis["apoptosis"]
    PU_1 -->|"activates"| Cholesterol["Cholesterol"]
    PU_1 -->|"activates"| Lymphoma["Lymphoma"]
    PU_1 -->|"activates"| Macrophage["Macrophage"]
    PU_1 -->|"activates"| B_Cell["B Cell"]
    PU_1 -->|"activates"| MACROPHAGES["MACROPHAGES"]
    PU_1 -->|"activates"| MAPK["MAPK"]
    S1PR1["S1PR1"] -->|"upregulates"| PU_1
    S1P1["S1P1"] -->|"upregulates"| PU_1
    MERTK["MERTK"] -->|"activates"| PU_1
    IL_10["IL-10"] -->|"activates"| PU_1
    late["late"] -->|"activates"| PU_1
    mTOR["mTOR"] -->|"activates"| PU_1

Outgoing (12)

Target	Relation	Type	Str
transcriptional_regulation	mediates	process	0.90
Macrophage Polarization	regulates	process	0.85
Lipid Metabolism	regulates	process	0.80
NF-κB	induces_transcriptional_reprogramming_via	gene	0.80
lipid droplet accumulation	promotes	phenotype	0.80
Cholesterol	activates	pathway	0.50
Lymphoma	activates	disease	0.50
Macrophage	activates	cell_type	0.50
B Cell	activates	cell_type	0.50
MACROPHAGES	activates	concept	0.50
MAPK	activates	gene	0.50
apoptosis	activates	process	0.50

Incoming (8)

Source	Relation	Type	Str
SPI1	encodes	gene	0.90
S1P1	upregulates	receptor	0.85
APOE4	induces_transcriptional_reprogramming_via	gene	0.80
APOE	regulates	gene	0.60
MERTK	activates	gene	0.50
IL-10	activates	protein	0.50
late	activates	disease	0.50
mTOR	activates	entity	0.50

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
HDAC2-Specific Repression of PU.1 Pioneer Factor Target Site	0.415	neurodegeneration	How does HDAC1/2 deletion specifically e
PU.1 Degradation via PROTAC for Inflammatory Microglial Pola	0.408	neurodegeneration	Microglial subtypes in neurodegeneration

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does SPI1 transcriptionally regulate C1QA and C1QC expression in atheroscler

neuroinflammation | 2026-04-08 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The authors identify SPI1 as a potential transcription factor regulating the hub

closed · Rounds: 4 · Score: 0.93 · 2026-04-09

Related Research

Hypotheses and analyses mentioning PU.1 in their description or question text

No additional research found