gene 766 words KG: SOD2
Contents

SOD2 Gene

🧬 Gene Info
Gene SymbolSOD2
Full NameSuperoxide Dismutase 2, Mitochondrial
Chromosome6q25.3
FunctionSOD2 provides essential mitochondrial antioxidant defense
Molecular Weight22.3 kDa
Amino Acids222 aa
Exons5
PathwaysAkt, Apoptosis, Mapk, Mitochondrial Function, Mtor
NCBI Gene ID6648
Ensembl IDENSG00000112096
OMIM147460
GeneCardsSOD2
Human Protein AtlasSOD2
Associated DiseasesAging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Cancer
Known Drugs/Compoundsberberine, BERBERINE, Lactiplantibacillus plantarum FRT4, resveratrol, RESVERATROL
InteractionsACHE, AD, AGING, AKT, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections816 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (29)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.56
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.82
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73
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Related Analyses (10)

Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

See Also (15)

Exosomal Biomarkers in Neurodegeneration
biomarker · Pages share 8 hypotheses
Exosomal miR-155 in Neurodegeneration
biomarker · Pages share 8 hypotheses
IL-6 (Interleukin-6) in Neurodegeneration
biomarker · Pages share 8 hypotheses
Liquid Biopsy in Neurodegeneration
biomarker · Pages share 8 hypotheses
Metabolomic Biomarkers in Neurodegeneration
biomarker · Pages share 8 hypotheses

Knowledge Graph (12 edges)

SOD2 therapeutic_target PPARGC1A
SOD2 therapeutic_target SIRT3
SOD2 therapeutic_target PRKAA1
SOD2 therapeutic_target CREBBP
SOD2 activates FOXO1
SOD2 associated_with CDC42
SOD2 associated_with CYCS
SOD2 associated_with GFAP
SOD2 therapeutic_target RAC1
SOD2 therapeutic_target MET

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