gene 1,452 words KG: RPS6KA1
Contents

RPS6KA1 — Ribosomal Protein S6 Kinase A1

🧬 Gene Info
Gene SymbolRPS6KA1
Full NameRibosomal Protein S6 Kinase A1
Chromosome1p36.11
Protein FamilyRibosomal S6 Kinase (RSK) family
Protein TypeSerine/Threonine Kinase
Functionis a serine/threonine kinase that serves as a critical effector of the MAPK/ERK signaling pathway.
Amino Acids735 aa
PathwaysMAPK, mapk
NCBI Gene ID6195
GeneCardsRPS6KA1
Human Protein AtlasRPS6KA1
Associated DiseasesAls, Cancer, Carcinoma
KG Connections27 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (5)

APOE-Dependent Autophagy Restoration
Score: 0.88
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Apoptosis in Neurodegeneration
entity · KG edge: therapeutic_target
Genes
index · KG edge: therapeutic_target
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: therapeutic_target
CAPN1 Gene
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

CAPN1 therapeutic_target RPS6KA1
TTR therapeutic_target RPS6KA1
LGALS3 therapeutic_target RPS6KA1
CTSD therapeutic_target RPS6KA1
GRB2 therapeutic_target RPS6KA1
TLR4 therapeutic_target RPS6KA1
NFE2L2 therapeutic_target RPS6KA1
RPS6KA1 therapeutic_target HIF1A
RPS6KA1 therapeutic_target GRIN1
RPS6KA1 therapeutic_target ADAM10

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