| Gene Symbol | RPS6KA2 |
| Full Name | Ribosomal Protein S6 Kinase A2 |
| Aliases | p90RSK3 |
| Protein Type | Kinase |
| Function | is a member of the p90 ribosomal S6 kinase (RSK) family of serine/threonine protein kinases. |
| Primary Expression | neuronal tissues and has been increasingly studied for its roles in neurodevelopment and neurodegeneration |
| Amino Acids | 733 aa |
| Pathways | MAPK |
| Ensembl ID | ENSG00000071242 |
| GeneCards | RPS6KA2 |
| Human Protein Atlas | RPS6KA2 |
| ERK1/2 binding | Through D-domain motifs in the C-terminus |
| Phosphorylation by ERK1/2 | At Ser380 (major activation site) |
| Autophosphorylation | Subsequent autophosphorylation at multiple sites |
| PDK1 phosphorylation | At Thr577 in the N-terminal kinase domain |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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