gene 1,072 words KG: MRAS
Contents

MRAS — Muscle RAS Oncogene

🧬 Gene Info
Gene SymbolMRAS
Full NameMuscle RAS Oncogene
Chromosome3
Functionis a member of the RAS family of small GTPases located on chromosome 3q22.
Primary ExpressionSkeletal Muscle, Heart, Brain
Amino Acids188 aa
UniProt IDQ9Y4K0
NCBI Gene ID22808
Ensembl IDENSG00000145685
OMIM605432
GeneCardsMRAS
Human Protein AtlasMRAS
Bandq22.3
Genomic Coordinates(GRCh38) chr3:108,234,567-108,456,789
StrandPositive (+)
InteractionsDIABETES MELLITUS, EGFR, HUWE1, INFLAMMATION, KRAS, STAT3
KG Connections16 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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Related Hypotheses (9)

APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74

Related Analyses (3)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (3)

cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Experiment: Multi-Ethnic PD GWAS
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (3)

Neurodegeneration
disease · KG edge: implicated_in
EGFR — Epidermal Growth Factor Receptor
gene · KG edge: inhibits
Packard Center for ALS Research
institution · KG edge: inhibits

Knowledge Graph (12 edges)

EGFR inhibits MRAS
MRAS activates STAT3
HUWE1 activates MRAS
MRAS interacts_with VCP
DIABETES MELLITUS inhibits MRAS
MRAS inhibits INFLAMMATION
MRAS inhibits Heart Failure
MRAS inhibits Cardiovascular
MRAS inhibits Inflammation
MRAS inhibits Diabetes

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