concept

MAPK PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAPK PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

85Connections

1Hypotheses

0Analyses

50Outgoing

31Incoming

0Experiments

0Debates

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💡 Concept Info

Name	MAPK PATHWAY
Key Genes/Proteins	AKT, BACE1, BRAF, CCL2, DRP1, ERK
Related Diseases	ALS, ALZHEIMER'S DISEASE, APOPTOSIS, CANCER, CYTOKINES

Pathway Diagram

graph TD
    MAPK_PATHWAY["MAPK PATHWAY"]
    MAPK_PATHWAY -->|"causes"| Oncogene_Induced_Senescence["Oncogene-Induced Senescence"]
    MAPK_PATHWAY -->|"regulates"| Senescence_Associated_Secretor["Senescence-Associated Secretory Phenotype"]
    MAPK_PATHWAY -->|"causes"| Langerhans_Cell_Histiocytosis["Langerhans Cell Histiocytosis"]
    MAPK_PATHWAY -->|"promotes"| Langerhans_cell_histiocytosis["Langerhans cell histiocytosis"]
    MAPK_PATHWAY -->|"involved_in"| Vascular_Remodelling["Vascular Remodelling"]
    MAPK_PATHWAY -->|"drives"| histiocyte_clonal_expansion["histiocyte clonal expansion"]
    MAPK_PATHWAY -->|"regulates"| cell_growth["cell growth"]
    MAPK_PATHWAY -.biomarker for.-> pilocytic_astrocytoma["pilocytic astrocytoma"]
    RAS["RAS"] -->|"activates"| MAPK_PATHWAY
    KIAA1549__BRAF["KIAA1549::BRAF"] -->|"activates"| MAPK_PATHWAY
    Trametinib["Trametinib"] -->|"inhibits"| MAPK_PATHWAY
    BRAF["BRAF"] -->|"activates"| MAPK_PATHWAY
    NST_628["NST-628"] -->|"inhibits"| MAPK_PATHWAY
    RIPK2["RIPK2"] -->|"activates"| MAPK_PATHWAY
    IRS1["IRS1"] -->|"component_of"| MAPK_PATHWAY

Outgoing (54)

Target	Relation	Type	Str
Oncogene-Induced Senescence	causes	process	0.95
Senescence-Associated Secretory Phenotype	regulates	phenotype	0.95
Langerhans cell histiocytosis	promotes	disease	0.90
Langerhans Cell Histiocytosis	causes	disease	0.90
Vascular Remodelling	involved_in	process	0.88
histiocyte clonal expansion	drives	process	0.85
amyotrophic lateral sclerosis	therapeutic_target	disease	0.80
Neurodegeneration	involved_in	process	0.75
pilocytic astrocytoma	biomarker_for	disease	0.70
pilocytic astrocytoma	associated_with	disease	0.70
cell growth	regulates	process	0.70
ERK	phosphorylates	gene	0.70
PINK1	causes	gene	0.65
SENESCENCE	causes	phenotype	0.65
NEUROINFLAMMATION	inhibits	phenotype	0.65
SENESCENCE	activates	phenotype	0.65
NEURODEGENERATION	activates	phenotype	0.65
DRP1	inhibits	gene	0.65
DRP1	causes	gene	0.65
DRP1	regulates	gene	0.65
OBESITY	interacts_with	disease	0.65
NRF2	associated_with	gene	0.50
OBESITY	associated_with	disease	0.50
NAC	associated_with	drug	0.45
GLIOMA	associated_with	disease	0.45
SENESCENCE	associated_with	phenotype	0.45
CYTOKINES	associated_with	phenotype	0.45
HDAC6	associated_with	gene	0.45
JNK	associated_with	gene	0.45
P38	associated_with	gene	0.45
BRAF	associated_with	gene	0.45
LACTATE	associated_with	phenotype	0.45
APOPTOSIS	associated_with	phenotype	0.45
BACE1	associated_with	gene	0.45
TAU	associated_with	protein	0.45
MAPT	associated_with	gene	0.45
PINK1	associated_with	gene	0.45
MITOPHAGY	associated_with	phenotype	0.45
DEPRESSION	associated_with	disease	0.45
MICROGLIA	associated_with	cell_type	0.45
MAPK	associated_with	gene	0.45
EZH2	associated_with	gene	0.45
ALS	associated_with	disease	0.45
DRP1	associated_with	gene	0.45
PYROPTOSIS	associated_with	phenotype	0.45
CANCER	associated_with	disease	0.45
ERK	associated_with	gene	0.45
PI3K	associated_with	gene	0.45
AKT	associated_with	gene	0.45
TNF	associated_with	gene	0.45

Incoming (31)

Source	Relation	Type	Str
RAS	activates	gene	0.95
RAF	activates	gene	0.95
KIAA1549::BRAF	activates	gene	0.95
RAS	activates	gene	0.95
BRAF	activates	gene	0.95
Trametinib	inhibits	drug	0.95
BRAF	activates	gene	0.95
NST-628	inhibits	drug	0.93
RIPK2	activates	protein	0.90
Ras/Raf	activates	pathway	0.90
RIPK2	activates	protein	0.85
DUSP8	regulates	gene	0.80
IRS1	component_of	protein	0.80
genetic changes	activates	process	0.70
HAPLN4	interacts_with	gene	0.70
MICROGLIA	activates	cell_type	0.65
LACTATE	activates	phenotype	0.65
INFLAMMATION	activates	phenotype	0.65
INFLAMMATION	inhibits	phenotype	0.65
INFLAMMATION	regulates	phenotype	0.65
NEUROINFLAMMATION	regulates	phenotype	0.65
TNF	regulates	gene	0.65
MICROGLIA	inhibits	cell_type	0.65
OXIDATIVE STRESS	associated_with	phenotype	0.50
DIMETHYL FUMARATE	associated_with	drug	0.45
ALZHEIMER'S DISEASE	associated_with	disease	0.45
HYPERTENSION	associated_with	disease	0.45
NEURODEGENERATION	associated_with	phenotype	0.45
INFLAMMATION	associated_with	phenotype	0.45
TUMOR GROWTH	associated_with	phenotype	0.45
NEUROINFLAMMATION	associated_with	phenotype	0.45

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
DLK MAPK Pathway Inhibition to Block Tau-Induced Neurotoxici	0.634	neurodegeneration	Should microtubule-stabilizing drugs be

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MAPK PATHWAY in their description or question text

No additional research found