disease

Cachexia

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Cachexia: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

117Connections

0Hypotheses

0Analyses

31Outgoing

50Incoming

0Experiments

0Debates

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Disease Info

Associated Genes	AGING, CANCER, INFLAMMATION
KG Connections	117 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (1)

Knowledge base pages for this entity

PSP Weight Loss and Cachexia

mechanism · 956 words

→

Pathway Diagram

graph TD
    Cachexia["Cachexia"] -->|"activates"| Cancer["Cancer"]
    Cachexia["Cachexia"] -->|"therapeutic target"| Cancer_1["Cancer"]
    Cachexia["Cachexia"] -->|"associated"| Infection["Infection"]
    Cachexia["Cachexia"] -->|"activates"| Tumor["Tumor"]
    Cachexia["Cachexia"] -->|"activates"| Apoptosis["Apoptosis"]
    Cachexia["Cachexia"] -->|"activates"| Glycolysis["Glycolysis"]
    CANCER["CANCER"] -->|"activates"| Cachexia["Cachexia"]
    CANCER_2["CANCER"] -->|"therapeutic target"| Cachexia["Cachexia"]
    CANCER_3["CANCER"] -->|"associated"| Cachexia["Cachexia"]
    IL_6["IL-6"] -->|"activates"| Cachexia["Cachexia"]
    style Cachexia fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (31)

Target	Relation	Type	Str
Apathy	causes	phenotype	0.95
IL6	upregulates	protein	0.85
Clinical Depression	associated_with	phenotype	0.80
Cancer	therapeutic_target	disease	0.75
Cancer	activates	disease	0.75
Infection	associated_with	disease	0.65
Tumor	activates	disease	0.65
Apoptosis	activates	pathway	0.60
Glycolysis	activates	pathway	0.60
Nf-Κb	activates	pathway	0.60
Mtor	regulates	pathway	0.60
Circadian Rhythm	interacts_with	pathway	0.60
Nf-Κb	contributes_to	pathway	0.60
Mitochondrial Function	therapeutic_target	pathway	0.60
Bmp Signaling	activates	pathway	0.60
Mtor	contributes_to	pathway	0.60
Als	therapeutic_target	disease	0.55
Tumor	therapeutic_target	disease	0.55
Carcinoma	activates	disease	0.55
Aging	associated_with	disease	0.55
Als	associated_with	disease	0.55
Als	regulates	disease	0.55
Diabetes	regulates	disease	0.55
Pancreatic Cancer	therapeutic_target	disease	0.55
Obesity	regulates	disease	0.55
Inflammation	regulates	disease	0.55
Cancer	regulates	disease	0.55
Cancer	associated_with	disease	0.55
Type 2 Diabetes	regulates	disease	0.55
CYTOKINE	activates	concept	0.50
DOPAMINE	activates	concept	0.50

Incoming (86)

Source	Relation	Type	Str
CANCER	activates	gene	0.95
CANCER	therapeutic_target	gene	0.95
CANCER	associated_with	gene	0.75
CYTOKINES	contributes_to	gene	0.75
IL-6	activates	gene	0.75
IL6	activates	gene	0.65
IGF1	contributes_to	gene	0.65
IL6	contributes_to	gene	0.65
NF-ΚB	contributes_to	gene	0.65
AKT	contributes_to	gene	0.65
MTOR	contributes_to	gene	0.65
PROINFLAMMATORY CYTOKINES	contributes_to	gene	0.65
FGF21	activates	gene	0.65
MITOCHONDRIA	activates	gene	0.65
ATP	activates	gene	0.65
AGING	regulates	gene	0.65
BAX	activates	gene	0.65
VDAC1	activates	gene	0.65
APOPTOSIS	activates	gene	0.65
INFLAMMATION	causes	gene	0.65
AGING	causes	gene	0.65
Als	therapeutic_target	disease	0.65
P62	activates	gene	0.65
SQSTM1	activates	gene	0.65
AGING	associated_with	gene	0.65
CYTOKINES	regulates	gene	0.65
INFLAMMATION	therapeutic_target	gene	0.65
NOX4	therapeutic_target	gene	0.65
SIRT1	therapeutic_target	gene	0.65
NF-ΚB	activates	gene	0.65
MTOR	regulates	gene	0.65
CANCER	interacts_with	gene	0.65
INFLAMMATION	activates	gene	0.65
TNF-Α	contributes_to	gene	0.65
EXERCISE	regulates	gene	0.65
INFLAMMATION	regulates	gene	0.65
CANCER	regulates	gene	0.65
AKT	regulates	gene	0.65
AGING	interacts_with	gene	0.65
TNF	contributes_to	gene	0.65
IL-6	contributes_to	gene	0.65
PDE4D	therapeutic_target	gene	0.65
CREB1	activates	gene	0.65
GENES	inhibits	gene	0.65
MITOCHONDRIAL DYSFUNCTION	contributes_to	gene	0.65
RANK	biomarker_for	gene	0.65
INFLAMMATION	biomarker_for	gene	0.65
CANCER	biomarker_for	gene	0.65
Tumor	biomarker_for	disease	0.55
Cancer	biomarker_for	disease	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning Cachexia in their description or question text

No additional research found