| Gene Symbol | RANKL (TNFSF11) |
| Full Name | Tumor Necrosis Factor Ligand Superfamily Member 11 |
| Aliases | TNFSF11 |
| Chromosome | 13q14 |
| Function | RANKL is a type II transmembrane protein that can exist in both membrane-bound and soluble forms[@lacey1998]. |
| Primary Expression | various tissues: - High Expression: Lymph nodes, thymus, bone marrow, spleen - Moderate Expression: Heart, skeletal muscle, brain - Cellular |
| Pathways | NF-κB |
| UniProt ID | O14788 |
| NCBI Gene ID | 9600 |
| Ensembl ID | ENSG00000120659 |
| OMIM | 602642 |
| Osteoclast Formation | RANKL binds to RANK on osteoclast precursors, triggering the NF-κB, c-Fos, and NFATc1 signaling cascades that drive differentiation into mature osteoclasts[@kong1999] |
| Bone Remodeling | The RANKL/OPG ratio determines bone resorption rates |
| Pathological Bone Loss | Elevated RANKL contributes to conditions like osteoporosis and rheumatoid arthritis |
| T Cell Co-stimulation | RANKL provides critical co-stimulatory signals for T cell activation and survival[@josien1999] |
| Associated Diseases | Als, neurodegeneration |
| Known Drugs/Compounds | Urolithin A |
| Interactions | Actin, AGING, AKT, AND, APOPTOSIS, App |
| KG Connections | 150 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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