gene

WNT3A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WNT3A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

104Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

WNT3A is a gene implicated in neurodegeneration research. Key relationships include: inhibits, activates, expressed in. Associated with ALS, Als, Alzheimer. Connected to 26 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	WNT3A
Chromosome	17q21.31
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	36 kDa
Amino Acids	352 aa
Exons	4
Pathways	Wnt, WNT
NCBI Gene ID	89780
Ensembl ID	ENSG00000134245
GeneCards	WNT3A
Human Protein Atlas	WNT3A
Associated Diseases	neurodegeneration
Interactions	Actin, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, BETA-CATENIN
KG Connections	104 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

WNT3A Gene

gene · 806 words

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WNT3A Protein

protein · 598 words

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Pathway Diagram

graph TD
    WNT3A["WNT3A"]
    Cancer{"Cancer"}
    WNT3A -->|"activates"| Cancer
    Inflammation{"Inflammation"}
    WNT3A -->|"expressed in"| Inflammation
    ALS{"ALS"}
    WNT3A -->|"inhibits"| ALS
    Alzheimer{"Alzheimer"}
    WNT3A -->|"inhibits"| Alzheimer
    WNT3A -->|"inhibits"| Cancer
    P38["P38"]
    WNT3A -->|"activates"| P38
    Wnt(["Wnt"])
    WNT3A -->|"activates"| Wnt
    Mapk(["Mapk"])
    WNT3A -->|"activates"| Mapk
    INFLAMMATION["INFLAMMATION"]
    WNT3A -->|"expressed in"| INFLAMMATION
    Epigenetic(["Epigenetic"])
    WNT3A -->|"inhibits"| Epigenetic
    WNT3A -->|"inhibits"| Wnt
    CANCER["CANCER"]
    WNT3A -->|"inhibits"| CANCER
    KLF14["KLF14"]
    KLF14 -->|"inhibits"| WNT3A
    CANCER -->|"activates"| WNT3A
    LRP6["LRP6"]
    LRP6 -->|"inhibits"| WNT3A
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"inhibits"| WNT3A
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"inhibits"| WNT3A
    CANCER -->|"inhibits"| WNT3A
    AND["AND"]
    AND -->|"inhibits"| WNT3A
    HDAC["HDAC"]
    HDAC -->|"inhibits"| WNT3A
    style WNT3A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (53)

Target	Relation	Type	Str
Wnt	inhibits	pathway	0.70
WNT PATHWAY	activates	pathway	0.70
Fibrosis	inhibits	disease	0.65
Nephropathy	activates	disease	0.65
Inflammation	expressed_in	disease	0.65
ALS	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Als	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
NEUROGENESIS	activates	phenotype	0.65
Als	activates	disease	0.65
AMYLOID	inhibits	protein	0.65
Als	inhibits	disease	0.65
Actin	activates	protein	0.60
DKK-1	activates	gene	0.60
LRP6	therapeutic_target	gene	0.60
LRP6	inhibits	gene	0.60
Wnt	activates	pathway	0.60
Mapk	activates	pathway	0.60
INFLAMMATION	expressed_in	gene	0.60
Epigenetic	inhibits	pathway	0.60
CANCER	inhibits	gene	0.60
AND	activates	gene	0.60
WNT	activates	gene	0.60
WNT	inhibits	gene	0.60
AND	inhibits	gene	0.60
Epigenetic	therapeutic_target	pathway	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
Wnt	regulates	pathway	0.60
Macrophage	activates	cell_type	0.60
P38	activates	gene	0.60
Ras	activates	protein	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
stem cells	expressed_in	cell_type	0.60
ATP6AP2	regulates	gene	0.60
neurons	expressed_in	cell_type	0.60
RANK	activates	gene	0.60
Osteoclast	activates	cell_type	0.60
thalamus	expressed_in	brain_region	0.60
WNT5A	expressed_in	gene	0.60
CACNA1G	activates	gene	0.60
Neuron	activates	cell_type	0.60
Wnt signaling	participates_in	pathway	0.60
Neuron	expressed_in	cell_type	0.55
Hippocampus	expressed_in	brain_region	0.55
Thalamus	expressed_in	brain_region	0.55
BETA-CATENIN	activates	protein	0.50

Incoming (51)

Source	Relation	Type	Str
h-eef1be45	targets	hypothesis	0.90
KLF14	inhibits	gene	0.80
NEURONS	treats	cell_type	0.65
DEPRESSION	activates	disease	0.65
GFAP	regulates	gene	0.65
NEURONS	inhibits	cell_type	0.65
STROKE	regulates	disease	0.65
STROKE	activates	disease	0.65
WNT SIGNALING	activates	pathway	0.65
DEPRESSION	regulates	disease	0.65
AND	activates	gene	0.60
DKK1	activates	gene	0.60
TAC1	activates	gene	0.60
TRPM8	activates	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
GENES	activates	gene	0.60
WNT	regulates	gene	0.60
RHOA	inhibits	gene	0.60
ROCK1	inhibits	gene	0.60
CAV3	activates	gene	0.60
LEF1	activates	gene	0.60
CACNA1G	activates	gene	0.60
CTNNB1	activates	gene	0.60
EGFR	activates	gene	0.60
MYC	activates	gene	0.60
TGFB1	activates	gene	0.60
RANKL	activates	gene	0.60
CANCER	activates	gene	0.60
HDAC	inhibits	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
AND	inhibits	gene	0.60
PDGF	activates	gene	0.60
LRP6	inhibits	gene	0.60
WNT	inhibits	gene	0.60
CANCER	co_discussed	gene	0.50
NEURON	co_discussed	gene	0.50
ALZHEIMER	co_discussed	gene	0.50
LEF1	co_expressed_with	gene	0.50
LRP6	co_discussed	gene	0.50
WNT PATHWAY	associated_with	pathway	0.50
WNT SIGNALING	associated_with	pathway	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
NEUROGENESIS	associated_with	phenotype	0.45
STRIATUM	associated_with	brain_region	0.45
THALAMUS	associated_with	brain_region	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning WNT3A in their description or question text

No additional research found