gene

CFOS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CFOS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections

0Hypotheses

0Analyses

30Outgoing

13Incoming

0Experiments

0Debates

Summary

CFOS is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in, expressed in. Associated with Als, Alzheimer, Inflammation. Connected to 22 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CFOS
Full Name	FBJ murine osteosarcoma viral oncogene homolog
Chromosome	14q24.3
Protein Family	Fos transcription factor family (c-Fos, FosB, Fra-1, Fra-2)
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	62 kDa
Amino Acids	380 aa
Exons	4 exons
Pathways	Amyloid, Blood-Brain Barrier
GeneCards	CFOS
Human Protein Atlas	CFOS
Chromosomal location	14q24.3
Gene length	~9.5 kb
mRNA length	~2.2 kb
Full name	FBJ murine osteosarcoma viral oncogene homolog
Associated Diseases	neurodegeneration
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APOE, APOE3
KG Connections	43 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CFOS Gene

gene · 1046 words

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Pathway Diagram

graph TD
    CFOS["CFOS (immediate early gene)"]
    ERK1["ERK1 (MAPK signaling)"]
    APP["APP (amyloid precursor)"]
    APOE["APOE (apolipoprotein E)"]
    APOE4["APOE4 (risk allele)"]
    IL6["IL-6 (cytokine)"]
    DLK["DLK (kinase)"]
    BBB["Blood-Brain Barrier"]
    Neuroinflammation["Neuroinflammation"]
    Alzheimer["Alzheimer's Disease"]
    ALS["Amyotrophic Lateral Sclerosis"]
    Neurodegeneration["Neurodegeneration"]
    AMYLOID["Amyloid pathology"]

    ERK1 -->|"phosphorylates"| CFOS
    CFOS -->|"transcriptional activation"| APOE
    CFOS -->|"upregulates"| APOE4
    CFOS -->|"activates"| APP
    APP -->|"feedback loop"| CFOS
    CFOS -->|"induces"| IL6
    CFOS -->|"activates"| DLK
    CFOS -->|"disrupts"| BBB
    CFOS -->|"promotes"| Neuroinflammation
    IL6 -->|"amplifies"| Neuroinflammation
    APP -->|"generates"| AMYLOID
    CFOS -->|"contributes to"| Alzheimer
    CFOS -->|"associated with"| ALS
    Neuroinflammation -->|"drives"| Neurodegeneration
    Alzheimer -->|"feedback activation"| CFOS

    style CFOS fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    style ERK1 fill:#4a1a6b
    style DLK fill:#4a1a6b
    style APOE fill:#4a1a6b
    style APP fill:#4a1a6b
    style IL6 fill:#ef5350
    style APOE4 fill:#ef5350
    style BBB fill:#ef5350
    style Neuroinflammation fill:#ef5350
    style AMYLOID fill:#ef5350
    style Alzheimer fill:#7d4200
    style ALS fill:#7d4200
    style Neurodegeneration fill:#7d4200

Outgoing (30)

Target	Relation	Type	Str
Inflammation	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Als	expressed_in	disease	0.65
Ms	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Als	activates	disease	0.65
Anxiety	expressed_in	disease	0.65
Alzheimer	activates	disease	0.65
ALZHEIMER'S DISEASE	activates	gene	0.60
DEPRESSION	expressed_in	gene	0.60
Neuron	activates	cell_type	0.60
Ras	expressed_in	protein	0.60
ALZHEIMER	activates	gene	0.60
AMYLOID	activates	gene	0.60
APOE3	activates	gene	0.60
DLK	activates	gene	0.60
APP	activates	gene	0.60
RANK	activates	gene	0.60
APOE4	activates	gene	0.60
APOE	activates	gene	0.60
ERK1	activates	gene	0.60
BDNF	activates	gene	0.60
Rb	expressed_in	protein	0.60
IL-6	activates	gene	0.60
Amyloid	activates	pathway	0.60
GENES	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
Blood-Brain Barrier	activates	pathway	0.60
AND	activates	gene	0.60
Hippocampus	expressed_in	brain_region	0.55

Incoming (13)

Source	Relation	Type	Str
ERK1	activates	gene	0.60
APP	activates	gene	0.60
RANK	activates	gene	0.60
DLK	activates	gene	0.60
APOE	activates	gene	0.60
ERBB4	expressed_in	gene	0.60
FOSB	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
AND	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
AMYLOID	activates	gene	0.60
ANXIETY	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CFOS in their description or question text

No additional research found