gene

DLK

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DLK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

108Connections

1Hypotheses

0Analyses

50Outgoing

38Incoming

0Experiments

0Debates

Summary

DLK (MAP3K12) - key kinase in axonal injury signaling, JNK pathway activation, and Wallerian degeneration

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🧬 Gene Info

Gene Symbol	DLK
Full Name	Dual Leucine Zipper Kinase
Aliases	MAP3K12
Protein Type	Kinase
Function	DLK functions as a master regulator of the stress-activated protein kinase (SAPK) signaling cascade:
Molecular Weight	105 kDa
Pathways	cascade: ### Axonal Injury Response
Ensembl ID	ENSG00000116809
GeneCards	DLK
Human Protein Atlas	DLK
Associated Diseases	Aging
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APOE, APOE3
KG Connections	108 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DLK["DLK"]
    Ms{"Ms"}
    DLK -->|"activates"| Ms
    Dementia{"Dementia"}
    DLK -->|"inhibits"| Dementia
    Alzheimer{"Alzheimer"}
    DLK -->|"regulates"| Alzheimer
    Neurodegeneration{"Neurodegeneration"}
    DLK -->|"inhibits"| Neurodegeneration
    Als{"Als"}
    DLK -->|"inhibits"| Als
    DLK -->|"inhibits"| Ms
    Apoptosis(["Apoptosis"])
    DLK -->|"activates"| Apoptosis
    Mapk(["Mapk"])
    DLK -->|"activates"| Mapk
    PUMA["PUMA"]
    DLK -->|"activates"| PUMA
    Autophagy(["Autophagy"])
    DLK -->|"inhibits"| Autophagy
    Blood_Brain_Barrier(["Blood-Brain Barrier"])
    DLK -->|"inhibits"| Blood_Brain_Barrier
    Mitophagy(["Mitophagy"])
    DLK -->|"inhibits"| Mitophagy
    BAX["BAX"]
    BAX -->|"activates"| DLK
    PUMA -->|"activates"| DLK
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"inhibits"| DLK
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"inhibits"| DLK
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"regulates"| DLK
    ULK1["ULK1"]
    ULK1 -->|"inhibits"| DLK
    TAU_TANGLES["TAU TANGLES"]
    TAU_TANGLES -->|"inhibits"| DLK
    TAU_PATHOLOGY["TAU PATHOLOGY"]
    TAU_PATHOLOGY -->|"inhibits"| DLK
    TAU["TAU"]
    TAU -->|"inhibits"| DLK
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"inhibits"| DLK
    NAD["NAD"]
    NAD -->|"activates"| DLK
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"activates"| DLK
    style DLK fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (70)

Target	Relation	Type	Str
Mitochondrial Fission	activates	process	0.95
Neurodegeneration	mediates	process	0.95
c-Jun	phosphorylates	protein	0.90
DRP1 phosphorylation	phosphorylates	process	0.90
DRP1	phosphorylates	protein	0.90
mitochondrial fission	drives	process	0.90
Apoptosis	mediates	process	0.85
apoptosis pathway	participates_in	pathway	0.70
Dementia	inhibits	disease	0.65
Aging	causes	disease	0.65
Alzheimer	regulates	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Als	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Ms	activates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Als	activates	disease	0.65
Alzheimer	activates	disease	0.65
ALZHEIMER'S DISEASE	activates	gene	0.60
APOE3	activates	gene	0.60
Apoptosis	causes	pathway	0.60
Amyloid	activates	pathway	0.60
AXON	causes	gene	0.60
AND	causes	gene	0.60
APOPTOSIS	causes	gene	0.60
NEURODEGENERATIVE DISORDERS	causes	gene	0.60
Apoptosis	associated_with	pathway	0.60
T Cell	associated_with	cell_type	0.60
Neuron	causes	cell_type	0.60
Apoptosis	inhibits	pathway	0.60
Oligodendrocyte	inhibits	cell_type	0.60
Microglia	inhibits	cell_type	0.60
Neuron	inhibits	cell_type	0.60
AND	inhibits	gene	0.60
C-JUN	activates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
SARM1	regulates	gene	0.60
APP	activates	gene	0.60
RANK	activates	gene	0.60
APOE4	activates	gene	0.60
APOE	activates	gene	0.60
CFOS	activates	gene	0.60
ERK1	activates	gene	0.60
DRP1	causes	gene	0.60
JUN	activates	gene	0.60
ULK1	activates	gene	0.60
neurodegeneration	activates	disease	0.60
ULK1	regulates	gene	0.60
Apoptosis	activates	pathway	0.60

Incoming (38)

Source	Relation	Type	Str
NEURODEGENERATIVE DISORDERS	causes	gene	0.60
AXON	causes	gene	0.60
AND	causes	gene	0.60
APOPTOSIS	causes	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
INFLAMMATION	inhibits	gene	0.60
OLIGODENDROCYTE	inhibits	gene	0.60
ULK1	inhibits	gene	0.60
TAU	inhibits	gene	0.60
DRP1	causes	gene	0.60
APOE4	activates	gene	0.60
APOE	activates	gene	0.60
DRP1	associated_with	gene	0.60
APOE3	activates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
C-JUN	activates	gene	0.60
BAX	activates	gene	0.60
PUMA	activates	gene	0.60
APOPTOSIS	associated_with	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
AND	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
AMYLOID	activates	gene	0.60
ERK1	activates	gene	0.60
CFOS	activates	gene	0.60
APP	activates	gene	0.60
RANK	activates	gene	0.60
JUN	activates	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
MITOPHAGY	inhibits	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
TAU TANGLES	inhibits	gene	0.60
TAU PATHOLOGY	inhibits	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
NAD	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
AXON	activates	gene	0.60
SARM1	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
DLK MAPK Pathway Inhibition to Block Tau-Induced Neurotoxici	0.634	neurodegeneration	Should microtubule-stabilizing drugs be

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DLK in their description or question text

No additional research found

DLK