gene 630 words KG: PDGFRA
Contents

PDGFRA - Platelet Derived Growth Factor Receptor Alpha

🧬 Gene Info
Gene SymbolPDGFRA
Full NamePlatelet-Derived Growth Factor Receptor Alpha
AliasesPage for PDGFRA
Chromosome4q12
Protein TypeGene
FunctionPDGFRA signaling regulates cell proliferation, migration, and survival during development and tissue repair [@uniprot]:
Primary Expressionmesenchymal cells including fibroblasts, smooth muscle cells, and glial progenitors [@references]
Molecular Weight180 kDa
Amino Acids1086 aa
Exons23
PathwaysAkt, Differentiation, MAPK signaling, ubiquitin-proteasome
GeneCardsPDGFRA
Human Protein AtlasPDGFRA
Associated DiseasesALS, Cancer, Carcinoma, Glioma, Tumor
InteractionsAKT, AKT3, AND, App, CANCER, CDKN2A
SciDEX HypothesesOPC differentiation blockade contributes to white
KG Connections104 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (7)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.61
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.84
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68

Related Analyses (8)

SEA-AD Single-Cell Analysis: Cell-Type Vulnerability in Alzh
neurodegeneration · completed
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

Related Experiments (4)

PDGFRA and C-MYC protein validation in ovarian cancer tissue
exploratory · proposed · Score: 0.85
Proposed experiment from debate on Perivascular spaces and g
falsification · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (15)

NeuRon Therapeutics
company · KG edge: activates
Genes
index · KG edge: expressed_in
ATRX — Alpha Thalassemia/Mental Retardation Syndrome X-
gene · KG edge: associated_with
cdkn2a
gene · KG edge: associated_with
EGFR — Epidermal Growth Factor Receptor
gene · KG edge: associated_with

Knowledge Graph (12 edges)

GLI1 regulates PDGFRA
PDGFRB interacts_with PDGFRA
GRIK3 inhibits PDGFRA
SRC activates PDGFRA
GRID2 inhibits PDGFRA
PDGFRA associated_with PI3K
PDGFRA associated_with AKT
PDGFRA activates IL6R
PDGFRA activates AKT
PDGFRA inhibits EPHA2

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