| Gene Symbol | PDGFRB |
| Full Name | Platelet Derived Growth Factor Receptor Beta |
| Chromosome | 5q32 |
| Protein Type | Kinase |
| Target Class | Kinase |
| Function | PDGFRB encodes the beta chain of the platelet-derived growth factor receptor, a receptor tyrosine kinase that binds PDGF-BB and PDGF-AB. |
| Mechanism of Action | Small molecule inhibitor of receptor tyrosine kinase activity |
| Druggability | Medium (0.50) |
| Clinical Stage | Approved |
| Pathways | PI3K, MAPK |
| UniProt ID | E5RII0 |
| Ensembl ID | ENSG00000113721 |
| OMIM | 173410 |
| GeneCards | PDGFRB |
| Human Protein Atlas | PDGFRB |
| Associated Diseases | Aging, Als, Alzheimers_disease, Basal Ganglia Calcifications, Cardiac |
| Known Drugs/Compounds | dasatinib, tyrosine_kinase_inhibitor |
| Interactions | ABCB1, ABL1, ABL2, AKT, AND, ANG |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | Pericyte Contractility Reset via Selective PDGFR-β Pericyte-First Sequential Biomarker Cascade — Solu Vascular mural cell degeneration precedes and exac (+1 more) |
| KG Connections | 575 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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