protein 885 words KG: PDGFBPROTEIN
Contents

PDGF-B Protein

🔬 Protein Info
Gene SymbolPDGF
Full NameB Protein
Subcellular LocalizationSecreted extracellular growth factor
UniProt IDP01127
GeneCardsPDGF
Human Protein AtlasPDGF
Protein NamePlatelet-Derived Growth Factor Subunit B (PDGF-B)
GenePDGFB
Primary Receptor BiasPDGFR-Beta Protein
Functional AxisPericyte recruitment, neurovascular stability, repair signaling
Associated DiseasesCancer, COGNITIVE DECLINE, Pulmonary Arterial Hypertension, Tumor
InteractionsAB, AD, AKT, AMPK, AND, ANGPT1
KG Connections396 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (13)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76

Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Proposed experiment from debate on Perivascular spaces and g
falsification · proposed · Score: 0.40

Key Papers (1)

APOE4 leads to blood-brain barrier dysfunction predicting cognitive de
Nature 2020 · 1 cites

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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