gene 537 words KG: PDGFB
Contents

PDGFB — Platelet Derived Growth Factor Subunit B

🧬 Gene Info
Gene SymbolPDGFB
Full NamePlatelet Derived Growth Factor Subunit B
Chromosome22q13
FunctionPDGFB encodes the B chain of platelet-derived growth factor, which can form homodimers (PDGF-BB) or heterodimers (PDGF-AB) with the A chain.
PathwaysInflammasome
UniProt ID[P01127](https://www.uniprot.org/uniprot/P01127)
Ensembl IDENSG00000127314
OMIM190040
GeneCardsPDGFB
Human Protein AtlasPDGFB
Associated DiseasesAging, Als, Basal Ganglia Calcifications, Fahr_disease, Ms
InteractionsApp, CMPK2, GENES, Il-1, IL-1, JAM2
KG Connections88 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (4)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
Retinal Vascular Microcirculation Rescue
Score: 0.72
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68
Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43

Related Analyses (4)

Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (9)

Cerebellum
brain · KG edge: expressed_in
Parkinson Basal Ganglia Circuit
circuit · KG edge: associated_with
Genes
index · KG edge: associated_with
BLM — Bloom Syndrome Protein
gene · KG edge: expressed_in
CSF2 — Colony Stimulating Factor 2 (GM-CSF)
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

PDGFB causes Fahr_disease
JUN associated_with PDGFB
JAM2 associated_with PDGFB
PDGFRB associated_with PDGFB
PDGFRB regulates PDGFB
PDGFB associated_with PDGFRB
PDGFRB expressed_in PDGFB
PDGFB regulates PDGFRB
PDGFB expressed_in BLM
PDGFB expressed_in Basal Ganglia

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