gene

SIRT2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SIRT2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

284Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Sirtuin 2 - NAD+-dependent deacetylase regulating microtubule acetylation, oxidative stress, and neurodegeneration in Parkinson's and Alzheimer's disease.

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🧬 Gene Info

Gene Symbol	SIRT2
Full Name	Sirtuin 2
Chromosome	19q13.32
Function	This function is critical for
Primary Expression	both cytoplasmic and nuclear compartments
Subcellular Localization	Primary: Cytoplasm, where it deacetylates alpha-tubulin
Molecular Weight	43 kDa
Amino Acids	389 aa
Exons	13 coding exons
Pathways	Autophagy, Necroptosis, Oxidative Stress
UniProt ID	Q8IXJ6
NCBI Gene ID	22933
Ensembl ID	ENSG00000145335
OMIM	604479
GeneCards	SIRT2
Human Protein Atlas	SIRT2
Associated Diseases	aging, ALS, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	MMP9_IN1
Interactions	AGING, AIM2, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYLOID
KG Connections	284 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SIRT2 — AlphaFold Q8IXJ6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    SIRT2["SIRT2"] -->|"regulates"| Inflammation["Inflammation"]
    SIRT2["SIRT2"] -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    SIRT2["SIRT2"] -->|"associated with"| Parkinson["Parkinson"]
    SIRT2["SIRT2"] -->|"associated with"| Alzheimer["Alzheimer"]
    SIRT2["SIRT2"] -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    SIRT2["SIRT2"] -->|"associated with"| Huntington["Huntington"]
    SIRT2["SIRT2"] -->|"regulates"| Ms["Ms"]
    SIRT2["SIRT2"] -->|"regulates"| Als["Als"]
    SIRT2["SIRT2"] -->|"associated with"| Inflammation["Inflammation"]
    SIRT2["SIRT2"] -.->|"inhibits"| Alzheimer["Alzheimer"]
    SIRT2["SIRT2"] -.->|"inhibits"| Als["Als"]
    SIRT2["SIRT2"] -.->|"inhibits"| Neuroinflammation["Neuroinflammation"]
    style SIRT2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Neurodegeneration fill:#ef5350,stroke:#333,color:#e0e0e0
    style Parkinson fill:#ef5350,stroke:#333,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Neuroinflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Huntington fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (186)

Target	Relation	Type	Str
age-related cardiac dysfunction	therapeutic_target	disease	0.95
cardiac senescence	prevents	phenotype	0.90
heart	expressed_in	brain_region	0.90
STAT3	deacetylates	protein	0.85
SIRT5	expressed_in	gene	0.80
Inflammation	regulates	disease	0.75
Inflammation	expressed_in	disease	0.75
NRF2	interacts_with	protein	0.75
Als	inhibits	disease	0.75
Inflammation	inhibits	disease	0.75
INFLAMMATION	expressed_in	gene	0.70
SIRT3	expressed_in	gene	0.70
SIRT7	expressed_in	gene	0.70
SIRT1	expressed_in	gene	0.70
Als	activates	disease	0.65
Aging	activates	disease	0.65
Sepsis	activates	disease	0.65
Cardiac	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Ms	regulates	disease	0.65
Huntington	associated_with	disease	0.65
Melanoma	inhibits	disease	0.65
Obesity	activates	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Senescence	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Als	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Inflammation	associated_with	disease	0.65
Autoimmune	expressed_in	disease	0.65
ALS	inhibits	disease	0.65
Neurodegeneration	regulates	disease	0.65
NEURODEGENERATION	targets	phenotype	0.65
MICROGLIA	targets	cell_type	0.65
COGNITIVE DECLINE	exacerbates	phenotype	0.65
Alzheimer	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
OXIDATIVE_STRESS	inhibits	phenotype	0.64
NRF2	activates	protein	0.60
amyloid aggregation	protects_against	process	0.60
necroptosis	regulates	process	0.60
HDAC2	regulates	gene	0.60
microglia	expressed_in	cell_type	0.60
Alzheimer's disease	inhibits	disease	0.60
AND	inhibits	gene	0.60
SIRT6	associated_with	gene	0.60
Alzheimer's disease	implicated_in	disease	0.60
necroptosis	participates_in	pathway	0.60

Incoming (98)

Source	Relation	Type	Str
NEURON	regulates	cell_type	0.70
SIRT6	expressed_in	gene	0.70
SIRT4	expressed_in	gene	0.70
MMP9_IN1	activates	drug	0.60
AMYLOID	inhibits	gene	0.60
GENES	associated_with	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
HUNTINGTON	associated_with	gene	0.60
MITOCHONDRIA	expressed_in	gene	0.60
AGING	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
PHAGOCYTOSIS	inhibits	gene	0.60
AGING	associated_with	gene	0.60
NRF2	regulates	gene	0.60
TAU	regulates	gene	0.60
SIRT3	expressed_in	gene	0.60
STAT3	therapeutic_target	gene	0.60
AIM2	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
NLRC4	inhibits	gene	0.60
GPR109A	inhibits	gene	0.60
C2	inhibits	gene	0.60
IMMUNE INFILTRATION	regulates	gene	0.60
GENES	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
NAD	expressed_in	gene	0.60
AGING	activates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
NEURODEGENERATIVE DISORDERS	regulates	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
HDAC	regulates	gene	0.60
HDAC4	inhibits	gene	0.60
HDAC6	activates	gene	0.60
HDAC6	targets	gene	0.60
HDAC6	implicated_in	gene	0.60
INFLAMMATION	inhibits	gene	0.60
AMPK	inhibits	gene	0.60
AND	inhibits	gene	0.60
EXERCISE	inhibits	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
AND	regulates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AMYLOID-BETA	inhibits	gene	0.60
APP/PS1	activates	gene	0.60
PS1	protects_against	gene	0.60
LDHA	activates	gene	0.60
RNA	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SIRT2 in their description or question text

No additional research found