| Gene Symbol | PDK1 |
| Function | Recent advances in proteomics have revealed remarkable convergence in protein alterations across distinct neurodegenerative diseases |
| Pathways | Cell Cycle, Differentiation, Glycolysis, Mitosis, Pi3K/Akt |
| GeneCards | PDK1 |
| Human Protein Atlas | PDK1 |
| Increased amyloid-related proteins | Elevated Aβ1-40, Aβ1-42 in cerebrospinal fluid (CSF) |
| Lipid metabolism alterations | Changes in apolipoproteins and lipid transport proteins |
| Synaptic protein reductions | Decreased synaptophysin, PSD95 |
| Inflammatory marker elevations | Increased IL-6, TNF-α, C-reactive protein |
| Tau pathology acceleration | Higher CSF tau and p-tau levels |
| Accelerated cognitive decline | More rapid progression to dementia |
| Enhanced α-synuclein pathology | Increased Lewy body burden |
| Alterations in lipid metabolism | Similar to AD patterns |
| Immune activation signatures | Elevated microglial markers |
| White matter integrity reduction | Enhanced white matter lesion load |
| Associated Diseases | Aging, Als, Carcinoma, Cirrhosis, Infection, Ms |
| Interactions | AGING, AKT, AKT1, AND, APOPTOSIS, AUTOPHAGY |
| KG Connections | 176 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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