gene

FBP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FBP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections

0Hypotheses

0Analyses

13Outgoing

3Incoming

0Experiments

0Debates

Summary

FBP1 is a gene implicated in neurodegeneration research. Key relationships include: regulates, implicated in. Associated with Breast Cancer, Cancer, Carcinoma. Connected to 17 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	FBP1
Full Name	Fructose-1,6-bisphosphatase 1
Chromosome	9q22.33
Primary Expression	the liver and kidney, FBP1 also exhibits tumor suppressor functions in various cancers and may play roles in metabolic regulation in the brain[@dong20
Molecular Weight	37 kDa
Amino Acids	337 aa
Exons	7
Pathways	Glycolysis
UniProt ID	[P09467](https://www.uniprot.org/uniprot/P09467)
Ensembl ID	ENSG00000165140
GeneCards	FBP1
Human Protein Atlas	FBP1
N-terminal domain	Substrate binding site
C-terminal domain	Catalytic site
Allosteric regulation site	Binds AMP for inhibition
Associated Diseases	neurodegeneration
KG Connections	16 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

FBP1 Gene

gene · 968 words

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Pathway Diagram

graph TD
    FBP1["FBP1"]
    neurodegeneration{"neurodegeneration"}
    FBP1 -->|"implicated_in"| neurodegeneration
    CANCER["CANCER"]
    FBP1 -->|"regulates"| CANCER
    Hepatocellular_Carcinoma{"Hepatocellular Carcinoma"}
    FBP1 -->|"regulates"| Hepatocellular_Carcinoma
    Cancer{"Cancer"}
    FBP1 -->|"regulates"| Cancer
    Liver_Cancer{"Liver Cancer"}
    FBP1 -->|"regulates"| Liver_Cancer
    Carcinoma{"Carcinoma"}
    FBP1 -->|"regulates"| Carcinoma
    Hepatitis{"Hepatitis"}
    FBP1 -->|"regulates"| Hepatitis
    TP53["TP53"]
    FBP1 -->|"regulates"| TP53
    GENES["GENES"]
    FBP1 -->|"regulates"| GENES
    PDK1["PDK1"]
    FBP1 -->|"regulates"| PDK1
    ENO1["ENO1"]
    FBP1 -->|"regulates"| ENO1
    Tumor{"Tumor"}
    FBP1 -->|"regulates"| Tumor
    Breast_Cancer{"Breast Cancer"}
    FBP1 -->|"regulates"| Breast_Cancer
    Glycolysis["Glycolysis"]
    FBP1 -->|"regulates"| Glycolysis
    PGK1["PGK1"]
    PGK1 -->|"regulates"| FBP1
    GAPDH["GAPDH"]
    GAPDH -->|"regulates"| FBP1
    TKT["TKT"]
    TKT -->|"regulates"| FBP1
    style FBP1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (13)

Target	Relation	Type	Str
Cancer	regulates	disease	0.75
CANCER	regulates	gene	0.70
Hepatocellular Carcinoma	regulates	disease	0.65
Liver Cancer	regulates	disease	0.65
Carcinoma	regulates	disease	0.65
Hepatitis	regulates	disease	0.65
Tumor	regulates	disease	0.65
Breast Cancer	regulates	disease	0.65
GENES	regulates	gene	0.60
Glycolysis	regulates	pathway	0.60
TP53	regulates	gene	0.60
PDK1	regulates	gene	0.60
ENO1	regulates	gene	0.60

Incoming (3)

Source	Relation	Type	Str
PGK1	regulates	gene	0.60
GAPDH	regulates	gene	0.60
TKT	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FBP1 in their description or question text

No additional research found