gene

RNF20

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RNF20: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections

0Hypotheses

0Analyses

11Outgoing

5Incoming

0Experiments

0Debates

Summary

Page for RNF20

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🧬 Gene Info

Gene Symbol	RNF20
Chromosome	9q34.3
Protein Type	Ligase
Function	RNF20 (Ring Finger Protein 20) is an E3 ubiquitin-protein ligase encoded by the RNF20 gene located on chromosome 9q34.3[@kim2009]
UniProt ID	Q5VTL2
Ensembl ID	ENSG00000146727
GeneCards	RNF20
Human Protein Atlas	RNF20
H2B ubiquitination	Catalyzes H2B K120ub1, a modification associated with active transcription[@minsky2008]
Transcriptional elongation	H2B-K120ub1 facilitates RNA Pol II passage through chromatin[@pavri2006]
DNA damage response	H2B ubiquitination promotes homologous recombination repair[@moyal2011]
p53 regulation	RNF20 modulates p53 activity through H2B ubiquitination[@shema2008]
Colorectal cancer	RNF20 frequently downregulated; tumor suppressor function[@tarcic2012]
Breast cancer	RNF20 expression correlates with prognosis; loss promotes metastasis[@zhang2015]
Gastric cancer	RNF20 reduced in aggressive subtypes[@liu2015]
Associated Diseases	neurodegeneration
Interactions	CRLS1, NCOR1, PIKFYVE, PPAR, RNA, SGMS1
KG Connections	16 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: RNF20 — AlphaFold Q5VTL2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RNF20

gene · 651 words

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Pathway Diagram

flowchart TD
    RNF20(["RNF20"])
    Als["Als"]
    UBIQUITIN(["UBIQUITIN"])
    T_Cell["T Cell"]
    PPAR(["PPAR"])
    NCOR1(["NCOR1"])
    neurodegeneration["neurodegeneration"]

    RNF20 -->|"activates"| Als
    RNF20 -->|"regulates"| Als
    RNF20 -->|"associated with"| UBIQUITIN
    RNF20 -->|"activates"| T_Cell
    RNF20 -->|"regulates"| UBIQUITIN
    PPAR -->|"activates"| RNF20
    NCOR1 -->|"activates"| RNF20
    RNF20 -->|"implicated in"| neurodegeneration

    style RNF20 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (11)

Target	Relation	Type	Str
Als	activates	disease	0.65
Als	regulates	disease	0.65
T Cell	activates	cell_type	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
endothelial cells	expressed_in	cell_type	0.60
UBIQUITIN	associated_with	gene	0.60
UBIQUITIN	regulates	gene	0.60
Notch signaling	participates_in	pathway	0.60
VEGFA	activates	gene	0.60
VEGF	regulates	gene	0.60
SGMS1	activates	gene	0.60

Incoming (5)

Source	Relation	Type	Str
PIKFYVE	activates	gene	0.60
RNA	activates	gene	0.60
PPAR	activates	gene	0.60
NCOR1	activates	gene	0.60
CRLS1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RNF20 in their description or question text

No additional research found