gene

DLL4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DLL4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

112Connections

0Hypotheses

0Analyses

50Outgoing

35Incoming

0Experiments

0Debates

Summary

DLL4 is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with Als, Amyotrophic Lateral Sclerosis, Autoimmune. Connected to 38 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DLL4
Full Name	Delta-Like 4
Chromosome	15q15.1
Function	is a critical Notch ligand that plays essential roles in vascular development, blood-brain barrier formation, and neural stem cell function.
Primary Expression	multiple tissues with particularly important roles in:
Amino Acids	685 aa
Pathways	Notch, Notch signaling
UniProt ID	[Q9NRF0](https://www.uniprot.org/uniprot/Q9NRF0)
Ensembl ID	ENSG00000128917
GeneCards	DLL4
Human Protein Atlas	DLL4
Tip cell specification	DLL4-Notch signaling is critical for tip cell formation during angiogenesis
Iterative signaling	DLL4 can undergo regulated intramembrane proteolysis (RIP)
Fringe modification	DLL4-Notch interactions are modulated by glycosyltransferases
Associated Diseases	disease, neuroinflammation
Interactions	ALS, AMYOTROPHIC LATERAL SCLEROSIS, AND, ASTROCYTE, ASTROCYTES, CANCER
KG Connections	112 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DLL4 Gene

gene · 1588 words

→

DLL4 Protein

protein · 673 words

→

Pathway Diagram

graph TD
    DLL4["DLL4"]
    NOTCH1["NOTCH1"]
    DLL4 -->|"activates"| NOTCH1
    Cancer{"Cancer"}
    DLL4 -->|"activates"| Cancer
    Inflammation{"Inflammation"}
    DLL4 -->|"activates"| Inflammation
    Neurodegeneration{"Neurodegeneration"}
    DLL4 -->|"activates"| Neurodegeneration
    Als{"Als"}
    DLL4 -->|"regulates"| Als
    Neuroinflammation{"Neuroinflammation"}
    DLL4 -->|"activates"| Neuroinflammation
    Ms{"Ms"}
    DLL4 -->|"inhibits"| Ms
    Autoimmune{"Autoimmune"}
    DLL4 -->|"inhibits"| Autoimmune
    DLL4 -->|"activates"| Als
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    DLL4 -->|"activates"| Amyotrophic_Lateral_Sclerosis
    LRP1["LRP1"]
    DLL4 -->|"inhibits"| LRP1
    NOTCH2["NOTCH2"]
    DLL4 -->|"inhibits"| NOTCH2
    NOTCH2 -->|"inhibits"| DLL4
    LRP1 -->|"inhibits"| DLL4
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"activates"| DLL4
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"activates"| DLL4
    STAT3["STAT3"]
    STAT3 -->|"activates"| DLL4
    IL_6["IL-6"]
    IL_6 -->|"activates"| DLL4
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"activates"| DLL4
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"activates"| DLL4
    MOTOR_NEURONS["MOTOR NEURONS"]
    MOTOR_NEURONS -->|"activates"| DLL4
    HES1["HES1"]
    HES1 -->|"activates"| DLL4
    SOD1["SOD1"]
    SOD1 -->|"activates"| DLL4
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
    AMYOTROPHIC_LATERAL_SCLEROSIS -->|"activates"| DLL4
    style DLL4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (77)

Target	Relation	Type	Str
Neuroinflammation	associated_with	disease	0.90
Astrocyte Reactivity	upregulates	phenotype	0.90
NOTCH2	activates	gene	0.90
NOTCH1	activates	protein	0.90
IL-6	upregulates	protein	0.88
Notch signaling	participates_in	pathway	0.70
ALS	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Als	activates	disease	0.65
Autoimmune	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Neuroinflammation	activates	disease	0.65
Als	regulates	disease	0.65
Neurodegeneration	activates	disease	0.65
Inflammation	activates	disease	0.65
Cancer	activates	disease	0.65
Carcinoma	activates	disease	0.65
Tumor	activates	disease	0.65
NOTCH2	inhibits	gene	0.60
ASTROCYTE	activates	gene	0.60
NEURON	activates	gene	0.60
DNA	activates	gene	0.60
NOTCH	inhibits	gene	0.60
Astrocyte	activates	cell_type	0.60
Neuroinflammatory	associated_with	pathway	0.60
PD-1	activates	gene	0.60
AND	inhibits	gene	0.60
macrophages	expressed_in	cell_type	0.60
astrocytes	expressed_in	cell_type	0.60
blood-brain barrier	participates_in	pathway	0.60
multiple sclerosis	inhibits	disease	0.60
oligodendrocytes	expressed_in	cell_type	0.60
blood-brain barrier	expressed_in	brain_region	0.60
RUNX2	biomarker_for	gene	0.60
T cells	expressed_in	cell_type	0.60
HER2	implicated_in	gene	0.60
LRP1	inhibits	gene	0.60
LRP1	activates	gene	0.60
NOTCH1	biomarker_for	gene	0.60
VEGFA	biomarker_for	gene	0.60
NOTCH1	inhibits	gene	0.60
VEGFA	inhibits	gene	0.60
VEGFA	activates	gene	0.60
Notch	inhibits	pathway	0.60
NEUROINFLAMMATION	activates	gene	0.60
Angiogenesis	regulates	pathway	0.60
Notch	activates	pathway	0.60
Blood-Brain Barrier	activates	pathway	0.60
ALS	activates	gene	0.60
CCL2	activates	gene	0.60

Incoming (35)

Source	Relation	Type	Str
LRP1	upregulates	gene	0.85
LRP1	regulates	gene	0.80
ASTROCYTE	expresses	cell_type	0.80
ASTROCYTES	upregulates	cell_type	0.80
ASTROCYTE	activates	gene	0.60
AND	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
ALS	activates	gene	0.60
NOTCH1	activates	gene	0.60
CD31	biomarker_for	gene	0.60
CCL2	activates	gene	0.60
HES1	activates	gene	0.60
SOD1	activates	gene	0.60
STAT3	activates	gene	0.60
IL23A	associated_with	gene	0.60
DUOX2	activates	gene	0.60
IL1B	associated_with	gene	0.60
NOTCH2	inhibits	gene	0.60
LRP1	inhibits	gene	0.60
PD-L1	inhibits	gene	0.60
PD-1	activates	gene	0.60
AND	inhibits	gene	0.60
NEURODEGENERATION	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
IL-6	activates	gene	0.60
MICROGLIA	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
MOTOR NEURONS	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
AND	associated_with	gene	0.60
ROS	activates	gene	0.60
LRP1	activates	gene	0.50
Neuroinflammation	activates	process	0.50
Neuroinflammation	regulates	process	0.50
angiogenesis	co_mentioned	process	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DLL4 in their description or question text

No additional research found