gene

HES1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HES1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

75Connections

0Hypotheses

0Analyses

42Outgoing

33Incoming

0Experiments

0Debates

Summary

HES1 is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, expressed in. Associated with Aging, Als, Amyotrophic Lateral Sclerosis. Connected to 46 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	Hairy and Enhancer of Split 1
Aliases	HES1
Chromosome	3q29
Protein Type	Transcription Factor
Function	encodes a 282-amino acid protein that functions as a transcriptional repressor, binding to specific DNA sequences known as E-box motifs (CANNTG) in the promoters of target genes.
Amino Acids	282 aa
Pathways	Notch signaling, notch
UniProt ID	Q04723
NCBI Gene ID	3280
Ensembl ID	ENSG00000114315
Associated Diseases	neurodegeneration
Interactions	ALS, ALZHEIMER, ALZHEIMER DISEASE, AMYLOID, AMYOTROPHIC LATERAL SCLEROSIS, AND
KG Connections	75 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HES1 — AlphaFold Q04723 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

HES1 Gene

gene · 2200 words

→

HES1 (Hairy and Enhancer of Split 1) Protein

protein · 660 words

→

Pathway Diagram

graph TD
    HES1["HES1"]
    Ischemia{"Ischemia"}
    HES1 -->|"activates"| Ischemia
    Als{"Als"}
    HES1 -->|"expressed in"| Als
    HES1 -->|"activates"| Als
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    HES1 -->|"activates"| Amyotrophic_Lateral_Sclerosis
    HES1 -->|"inhibits"| Als
    NESTIN["NESTIN"]
    HES1 -->|"activates"| NESTIN
    NOTCH1["NOTCH1"]
    HES1 -->|"expressed in"| NOTCH1
    GFAP["GFAP"]
    HES1 -->|"activates"| GFAP
    Neurogenesis(["Neurogenesis"])
    HES1 -->|"activates"| Neurogenesis
    Notch(["Notch"])
    HES1 -->|"expressed in"| Notch
    ASTROCYTES["ASTROCYTES"]
    HES1 -->|"activates"| ASTROCYTES
    SOD1["SOD1"]
    HES1 -->|"activates"| SOD1
    NGF["NGF"]
    NGF -->|"activates"| HES1
    DCX["DCX"]
    DCX -->|"activates"| HES1
    BDNF["BDNF"]
    BDNF -->|"activates"| HES1
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"activates"| HES1
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"activates"| HES1
    MOTOR_NEURONS["MOTOR NEURONS"]
    MOTOR_NEURONS -->|"activates"| HES1
    NESTIN -->|"inhibits"| HES1
    GFAP -->|"inhibits"| HES1
    style HES1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (42)

Target	Relation	Type	Str
Als	activates	disease	0.75
Notch	expressed_in	pathway	0.70
Als	expressed_in	disease	0.65
Ischemia	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Depression	activates	disease	0.65
Als	inhibits	disease	0.65
Parkinson	activates	disease	0.65
Aging	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
PRESENILIN	activates	gene	0.60
Apoptosis	activates	pathway	0.60
NEURON	activates	gene	0.60
Caspase	activates	protein	0.60
Aβ	activates	protein	0.60
neurons	expressed_in	cell_type	0.60
OLIG2	inhibits	gene	0.60
ALZHEIMER	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
ALS	activates	gene	0.60
PSEN1	activates	gene	0.60
Notch	activates	pathway	0.60
Notch signaling	participates_in	pathway	0.60
Neurogenesis	activates	pathway	0.60
NOTCH	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
Amyloid	activates	pathway	0.60
SOD1	activates	gene	0.60
ASTROCYTES	inhibits	gene	0.60
DLL4	activates	gene	0.60
Tgf-Β	activates	pathway	0.60
IFN	activates	gene	0.60
NESTIN	activates	gene	0.60
NOTCH1	expressed_in	gene	0.60
GFAP	activates	gene	0.60
Microrna	activates	pathway	0.50
CASPASE-3	activates	protein	0.50
apoptosis	activates	process	0.50
CELL PROLIFERATION	activates	concept	0.50

Incoming (33)

Source	Relation	Type	Str
PSEN1	increases	gene	0.80
PSEN1	activates	gene	0.60
NGF	activates	gene	0.60
DCX	activates	gene	0.60
BDNF	activates	gene	0.60
MICROGLIA	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
MOTOR NEURONS	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
CYTOKINES	activates	gene	0.60
PARKINSON	activates	gene	0.60
IL-6	activates	gene	0.60
C-FOS	activates	gene	0.60
TNF-Α	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
DEPRESSION	activates	gene	0.60
ALS	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
AND	activates	gene	0.60
TNF	activates	gene	0.60
FOS	activates	gene	0.60
NOTCH1	expressed_in	gene	0.60
HES5	expressed_in	gene	0.60
GFAP	inhibits	gene	0.60
AMYLOID	activates	gene	0.60
NESTIN	inhibits	gene	0.60
ASTROCYTES	inhibits	gene	0.60
APOPTOSIS	activates	gene	0.60
ALZHEIMER DISEASE	activates	gene	0.60
ALZHEIMER	activates	gene	0.50
CASPASE-3	activates	protein	0.50
PRESENILIN	activates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HES1 in their description or question text

No additional research found