protein

CK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

46Connections

3Hypotheses

0Analyses

36Outgoing

10Incoming

0Experiments

0Debates

Summary

CK2 (Casein Kinase 2) is a constitutively active serine/threonine protein kinase that phosphorylates over 300 substrates involved in transcription, translation, cell cycle, and cell survival. It is implicated in Alzheimer's disease tau pathology and cancer.

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🔬 Protein Info

Gene Symbol	CK2
Aliases	Casein Kinase 2
Function	CK2 exists as a tetrameric holoenzyme composed of two catalytic subunits (α or α') and two regulatory β subunits. The regulatory β subunit enhances substrate specificity, modulates activity, and ta...
Molecular Weight	44 kDa
Pathways	Notch Signaling, blood-brain barrier
GeneCards	CK2
Human Protein Atlas	CK2
Associated Diseases	ALS, Alzheimer, Huntington's disease
Interactions	AQP4, ATP, BRAF, MAPK, MYH9, NPM1
KG Connections	46 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (5)

Knowledge base pages for this entity

Pathway Diagram

flowchart TD
    N0["CK2"]
    N1["Notch Signaling"]
    N0 -->|"regulates"| N1
    N2["MYH9"]
    N0 -->|"phosphorylates"| N2
    N3["E(SPL)M8"]
    N0 -->|"phosphorylates"| N3
    N4["Neurogenesis"]
    N4 -->|"involved in"| N0
    N5["KIF5"]
    N0 -->|"phosphorylates"| N5
    N6["PP2A"]
    N0 -->|"interacts with"| N6
    N7["MAPK"]
    N7 -->|"regulates"| N0
    N8["BRAF"]
    N8 -->|"activates"| N0
    N9["CDK1"]
    N9 -->|"co discussed"| N0
    N7 -->|"activates"| N0

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 pathway
    class N2 protein
    class N3 protein
    class N5 protein
    class N7 pathway
    class N8 gene
    class N9 gene

Outgoing (36)

Target	Relation	Type	Str
MYH9	phosphorylates	protein	0.87
PP2A	associated_with	gene	0.60
ALS	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
IRS1	regulates	gene	0.60
KIAA1549	regulates	gene	0.60
MAPK	regulates	gene	0.60
DRP1	regulates	gene	0.60
FUNDC1	regulates	gene	0.60
OPA1	regulates	gene	0.60
ULK1	regulates	gene	0.60
Alzheimer's disease	regulates	disease	0.60
mitochondrial function	participates_in	pathway	0.60
GSK3	implicated_in	gene	0.60
MAPK	implicated_in	gene	0.60
Huntington's disease	implicated_in	disease	0.60
Wnt signaling	participates_in	pathway	0.60
IKK	regulates	gene	0.60
MAPK14	regulates	gene	0.60
PP2A	regulates	gene	0.60
PP2B	regulates	gene	0.60
PERK	targets	gene	0.60
HDAC3	associated_with	gene	0.60
PERK	activates	gene	0.60
glymphatic clearance	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
Notch signaling	participates_in	pathway	0.60
PP2A	inhibits	gene	0.60
MAPK signaling	participates_in	pathway	0.60
CSNK2	regulates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
stroke	activates	disease	0.60
PKC	activates	gene	0.55
blood-brain barrier	participates_in	pathway	0.55
NPM1	activates	gene	0.55
PERK	co_expressed_with	gene	0.50

Incoming (10)

Source	Relation	Type	Str
ATP	interacts_with	gene	0.60
AQP4	activates	gene	0.60
AQP4	targets	gene	0.60
BRAF	regulates	gene	0.60
CDK1	regulates	gene	0.60
MAPK	regulates	pathway	0.56
AQP4	co_expressed_with	gene	0.50
BRAF	activates	gene	0.50
CDK1	co_discussed	gene	0.50
MAPK	activates	gene	0.50

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
H1: CK2 Hyperphosphorylation Locks G3BP1 in Hyper-condensed	0.637	neurodegeneration	How do pathological stress granules tran
Casein Kinase 2 (CK2)-Mediated Hyperphosphorylation of G3BP1	0.440	neurodegeneration	How do pathological stress granules in n
CK2-mediated HSP90α phosphorylation switches client discrimi	0.363	protein biochemistry	Do chaperones selectively recognize path

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CK2 in their description or question text

No additional research found

CK2