gene

DLL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DLL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

25Connections

0Hypotheses

0Analyses

19Outgoing

6Incoming

0Experiments

0Debates

Summary

DLL1 encodes Delta-Like 1, a Notch ligand crucial for neurogenesis, synaptic plasticity, and neural stem cell maintenance, with implications for Alzheimer's and Parkinson's disease

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🧬 Gene Info

Gene Symbol	DLL1
Full Name	Delta-Like 1
Chromosome	6q27
Function	encodes a transmembrane ligand of the Delta/Serrate/Lag-2 (DSL) family that activates Notch receptors through cell-cell contact.
Primary Expression	Brain (hippocampus, cortex, SVZ), neural stem cells, neurons, astrocytes
Molecular Weight	82 kDa
Amino Acids	723 aa
Exons	24
Pathways	Notch, Notch signaling
UniProt ID	O00548
NCBI Gene ID	28514
Ensembl ID	ENSG00000198719
OMIM	604552
GeneCards	DLL1
Human Protein Atlas	DLL1
Associated Diseases	Als, Autism
KG Connections	25 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DLL1 — AlphaFold O00548 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DLL1 Gene

gene · 1700 words

→

DLL1 Protein

protein · 648 words

→

Pathway Diagram

graph TD
    DLL1["DLL1"]
    Als{"Als"}
    DLL1 -->|"associated with"| Als
    Autism{"Autism"}
    DLL1 -->|"associated with"| Autism
    DLL1 -->|"regulates"| Als
    Ms{"Ms"}
    DLL1 -->|"regulates"| Ms
    Notch(["Notch"])
    DLL1 -->|"associated with"| Notch
    Lipid_Metabolism(["Lipid Metabolism"])
    DLL1 -->|"therapeutic target"| Lipid_Metabolism
    Sphingolipid(["Sphingolipid"])
    DLL1 -->|"therapeutic target"| Sphingolipid
    neurodegeneration["neurodegeneration"]
    DLL1 -->|"implicated in"| neurodegeneration
    NOS2["NOS2"]
    NOS2 -->|"therapeutic target"| DLL1
    CCL3["CCL3"]
    CCL3 -->|"therapeutic target"| DLL1
    ESR1["ESR1"]
    ESR1 -->|"therapeutic target"| DLL1
    ABCB1["ABCB1"]
    ABCB1 -->|"therapeutic target"| DLL1
    CIITA["CIITA"]
    CIITA -->|"therapeutic target"| DLL1
    style DLL1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (19)

Target	Relation	Type	Str
Autism	associated_with	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Depression	regulates	disease	0.65
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
Sphingolipid	therapeutic_target	pathway	0.60
Notch	regulates	pathway	0.60
Amyloid	regulates	pathway	0.60
endothelial cells	expressed_in	cell_type	0.60
NDRG2	regulates	gene	0.60
NLRP3	regulates	gene	0.60
NOTCH1	associated_with	gene	0.60
Notch signaling	participates_in	pathway	0.60
Notch	associated_with	pathway	0.60
Lipid Metabolism	therapeutic_target	pathway	0.60
BACE1	regulates	gene	0.60
Neuron	expressed_in	cell_type	0.55

Incoming (6)

Source	Relation	Type	Str
NOS2	therapeutic_target	gene	0.60
CCL3	therapeutic_target	gene	0.60
ESR1	therapeutic_target	gene	0.60
ABCB1	therapeutic_target	gene	0.60
CIITA	therapeutic_target	gene	0.60
MYC	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DLL1 in their description or question text

No additional research found