gene

AQP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AQP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

295Connections

1Hypotheses

1Analyses

50Outgoing

48Incoming

2Experiments

1Debates

Summary

AQP1 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, activates, therapeutic target. Associated with ALS, Aging, Als. Connected to 117 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	AQP1
Full Name	Aquaporin 1
Chromosome	7p14.3
Protein Type	Channel
Target Class	Ion Channel
Function	encodes a water channel protein that facilitates rapid water transport across cell membranes.
Mechanism of Action	AQP1 functions as a water channel protein facilitating transmembrane water flux, with emerging evidence suggesting its involvement in neuroinflammatory processes and potential contribution to neuronal cell volume regulation and edema formation in neurodegenerative conditions. In the context of neurodegeneration, AQP1 may modulate neuronal and glial cell responses to oxidative stress, inflammation, and cellular metabolic perturbations, making it a potential strategic target for therapeutic intervention.
Primary Expression	the central nervous system, particularly in the choroid plexus, where it plays a critical role in [cerebrospinal fluid (
Druggability	Low (0.39)
Clinical Stage	Approved
Molecular Weight	28 kDa
Pathways	Angiogenesis, Complement, Epigenetic, Glycolysis, Immune Response
UniProt ID	P29972
NCBI Gene ID	358
Ensembl ID	ENSG00000240583
OMIM	107700
GeneCards	AQP1
Human Protein Atlas	AQP1
Associated Diseases	aging, Als, Alzheimer
Known Drugs/Compounds	H2O2, Hydrogen Peroxide
Interactions	AGING, ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOPTOSIS, App
SciDEX Target	View Target Profile (6 clinical trials)
SciDEX Hypotheses	Osmotic Gradient Restoration via Selective AQP1 En
KG Connections	294 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure Comparison — AQP1 Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

1J4N — X-ray / Cryo-EM

🔮 AI Predicted Structure

P29972 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

AQP1 Gene

gene · 757 words

→

AQP1 Protein

protein · 672 words

→

Pathway Diagram

graph TD
    AQP1["AQP1"] -->|"regulates"| Endothelial_Cell_Senescence["Endothelial Cell Senescence"]
    AQP1["AQP1"] -->|"mediates"| Water_Transport["Water Transport"]
    AQP1["AQP1"] -->|"interacts"| H2O2["H2O2"]
    AQP1["AQP1"] -->|"modulates"| Cell_Cycle_Arrest["Cell-Cycle Arrest"]
    AQP1["AQP1"] -->|"modulates"| Senescence_Associated_Secretor["Senescence-Associated Secretory Phenotype"]
    AQP1["AQP1"] -->|"expressed in"| Aortic_Endothelial_Cells["Aortic Endothelial Cells"]
    h_0dea0ed5["h-0dea0ed5"] -->|"targets"| AQP1["AQP1"]
    HDAC4["HDAC4"] -.->|"inhibits"| AQP1["AQP1"]
    MEF2A["MEF2A"] -.->|"inhibits"| AQP1["AQP1"]
    AQP4["AQP4"] -->|"associated"| AQP1["AQP1"]
    style AQP1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (247)

Target	Relation	Type	Str
Water Transport	mediates	process	0.95
Endothelial Cell Senescence	regulates	process	0.95
Central Nervous System	expressed_in	cell_type	0.90
Angiogenesis	regulates	process	0.90
Central Nervous System Injury	involved_in	disease	0.90
Endothelial Cells	expressed_in	cell_type	0.90
Angiogenic Capacity	promotes	phenotype	0.90
Cell-Cycle Arrest	regulates	process	0.85
Senescence-Associated Secretory Phenotype	regulates	phenotype	0.85
peripheral nervous system	expressed_in	brain_region	0.85
H2O2	transports	compound	0.85
Edema	contributes_to	phenotype	0.85
Water Transport	involved_in	process	0.85
H2O2	interacts_with	compound	0.85
Dna Damage Response	modulates	process	0.85
Mitochondrial Dysfunction	modulates	phenotype	0.85
Dna Damage Response	regulates	process	0.85
Cerebral Edema	involved_in	disease	0.85
Hydrogen Peroxide	interacts_with	compound	0.85
CNS Injury	involved_in	disease	0.85
Glioblastoma Multiforme	involved_in	disease	0.80
AQP4	associated_with	gene	0.80
Alzheimer'S Disease	associated_with	disease	0.80
cardiovascular disease	implicated_in	disease	0.80
Spinal Cord Injury	involved_in	phenotype	0.80
endothelial cell senescence	orchestrates	process	0.80
Parkinson'S Disease	involved_in	disease	0.80
Cell-Cycle Arrest	modulates	phenotype	0.80
Senescence-Associated Secretory Phenotype	modulates	phenotype	0.80
Multiple Sclerosis	involved_in	disease	0.80
Amyotrophic Lateral Sclerosis	involved_in	disease	0.80
Aortic Endothelial Cells	expressed_in	cell_type	0.75
mitochondrial dysfunction	causes	phenotype	0.75
Inflammation	activates	disease	0.75
metabolic dysfunction	modulates	phenotype	0.75
TGF-beta signaling	participates_in	pathway	0.70
INFLAMMATION	activates	gene	0.70
Senescence	regulates	disease	0.65
Sepsis	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	expressed_in	disease	0.65
Als	associated_with	disease	0.65
Cardiac	therapeutic_target	disease	0.65
Aging	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Aging	regulates	disease	0.65
Infection	therapeutic_target	disease	0.65
Fibrosis	activates	disease	0.65
Als	transports	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Ms	expressed_in	disease	0.65

Incoming (48)

Source	Relation	Type	Str
h-0dea0ed5	targets	hypothesis	0.90
CX43	expressed_in	gene	0.60
AND	inhibits	gene	0.60
NLRP3	activates	gene	0.60
BACE1	activates	gene	0.60
AQP4	inhibits	gene	0.60
AMPK	associated_with	gene	0.60
AQP3	inhibits	gene	0.60
AQP5	associated_with	gene	0.60
BCL-2	expressed_in	gene	0.60
CANX	regulates	gene	0.60
APP/PS1	associated_with	gene	0.60
ALZHEIMER	activates	gene	0.60
NF-ΚB	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
AQP3	expressed_in	gene	0.60
CAMKII	transports	gene	0.60
HDAC4	inhibits	gene	0.60
MEF2A	inhibits	gene	0.60
AQP4	associated_with	gene	0.60
CFTR	regulates	gene	0.60
GAT1	regulates	gene	0.60
AQP4	expressed_in	gene	0.60
CFTR	transports	gene	0.60
GAT1	transports	gene	0.60
TLR4	activates	gene	0.60
PI3K	activates	gene	0.60
CASPASE3	expressed_in	gene	0.60
BAX	expressed_in	gene	0.60
angiogenesis	regulates	process	0.60
angiogenesis	activates	process	0.60
DNA	regulates	gene	0.60
AQP5	expressed_in	gene	0.60
AQP9	expressed_in	gene	0.60
AQP5	transports	gene	0.60
ABCC8	associated_with	gene	0.60
AMPK	transports	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
ASTROCYTE	expressed_in	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
PARKINSON	expressed_in	gene	0.60
AGING	inhibits	gene	0.60
GLIOBLASTOMA	expressed_in	gene	0.60
MIRNAS	regulates	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
APP	activates	gene	0.55
HCRTR2	co_discussed	gene	0.40

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Osmotic Gradient Restoration via Selective AQP1 Enhancement	0.680	neurodegeneration	Perivascular spaces and glymphatic clear

Mentioning Analyses (1)

Scientific analyses that reference this entity

Perivascular spaces and glymphatic clearance failure in AD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.860

Experiments (2)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs AD with Co	clinical	Alzheimer's Disease	0.900	0.50	aortic endothelial cells	proposed	$6,550,000
CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs AD with Co	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
AQP1 differentially orchestrates endothelial cell senescence. [PMID:39180980]	Shabanian K, Shabanian T, Karsai G, Pont	Redox Biol	2024	1
Non-Aquaporin Water Channels. [PMID:36717505]	Huang B, Wang H, Yang B	Adv Exp Med Biol	2023	1
Aquaporins in Nervous System. [PMID:28258567]	Xu M, Xiao M, Li S, Yang B	Adv Exp Med Biol	2017	1
Aquaporins in the Spinal Cord. [PMID:27941618]	Oklinski MK, Skowronski MT, Skowronska A	Int J Mol Sci	2016	1
Aquaporin gating. [PMID:16837191]	Hedfalk K, Törnroth-Horsefield S, Nyblom	Curr Opin Struct Biol	2006	1
Panax notoginseng saponins protect the blood-brain barrier against oxidative str [PMID:41763432]	Fan L, Qu S, Miao C, Wu D, Rao Y et al.	Int J Biol Macromol	2026	0
Stomatin encapsulates aquaporin-1 and urea transporter-B in the erythrocyte memb [PMID:41921000]	Vallese F, Li H, Barazzuol L, Calì T, Cl	Sci Adv	2026	0
Aquaporin membrane channels in the hepatobiliary tract: a model of complexity an [PMID:41926019]	Portincasa P, Khalil M, Calamita G	Intern Emerg Med	2026	0
Glycosomal Aquaglyceroporin 1 dual role in iron homeostasis and antimony suscept [PMID:41926379]	Boy RL, Zampieri RA, Aoki JI, Coelho AC,	PLoS Negl Trop Dis	2026	0
Aquaporin-1 Facilitates Macrophage M1 Polarization by Enhancing Glycolysis Throu [PMID:39365391]	["Diao R", "Lv W", "Wang Y", "Shen Q", "	Inflammation	2025	0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746]	["Sanadgol N", "Abedi M", "Hashemzaei M"	Journal of nanobiotechnology	2025	0
AQP1 Promoter Variant, Water Transport, and Outcomes in Peritoneal Dialysis. [PMID:34670044]	Morelle J, Marechal C, Yu Z, Debaix H, C	The New England journal of med	2021	0
Discovery of novel diarylamides as orally active diuretics targeting urea transp [PMID:33532188]	["Zhang S", "Zhao Y", "Wang S", "Li M",	Acta pharmaceutica Sinica. B	2021	0
Physiological and pathological impact of AQP1 knockout in mice. [PMID:31023968]	Hua Y, Ying X, Qian Y, Liu H, Lan Y, Xie	Bioscience reports	2019	0
The potential role of aquaporin 1 on aristolochic acid I induced epithelial mese [PMID:29215709]	["Li J", "Zhang M", "Mao Y", "Li Y", "Zh	Journal of cellular physiology	2018	0
Cardiotrophin-1 predicts death or heart failure following acute myocardial infar [PMID:17045183]	["Khan S", "Kelly D", "Quinn P", "Davies	Journal of cardiac failure	2006	0
Regulation of mitosis in response to damaged or incompletely replicated DNA requ [PMID:16079276]	["Purdy A", "Uyetake L", "Cordeiro M", "	Journal of cell science	2005	0
Physiological roles of aquaporins in the choroid plexus. [PMID:15949534]	Boassa D, Yool AJ	Current topics in developmenta	2005	0
Structural basis of ion pumping by Ca2+-ATPase of the sarcoplasmic reticulum. [PMID:15189143]	["Toyoshima C", "Inesi G"]	Annual review of biochemistry	2004	0
Su e of the yeast F1Fo-ATP synthase forms homodimers. [PMID:12377768]	["Brunner S", "Everard-Gigot V", "Stuart	The Journal of biological chem	2002	0

Debates (1)

Multi-agent debates referencing this entity

Perivascular spaces and glymphatic clearance failure in AD

closed · Rounds: 4 · Score: 0.95 · 2026-04-06

Related Research

Hypotheses and analyses mentioning AQP1 in their description or question text

No additional research found