gene 519 words KG: NRAS
Contents

NRAS Gene

🧬 Gene Info
Gene SymbolNRAS
Full NameNRAS Proto-Oncogene, GTPase
Chromosome1p13.2
FunctionNRAS is a member of the Ras family of small GTPases that cycles between active GTP-bound and inactive GDP-bound states.
Primary Expressionthe brain with high expression in the hippocampus, cortex, and cerebellum
Molecular Weight21.2 kDa
Amino Acids189 aa
PathwaysMAPK, PI3K, MAPK signaling
UniProt IDP01111
Ensembl IDENSG00000213281
GeneCardsNRAS
Human Protein AtlasNRAS
BrainNeurons, astrocytes, and microglia
SkinMelanocytes and keratinocytes
Immune SystemT cells, B cells, and myeloid cells
Associated DiseasesAls, Cancer, epilepsy, Ms
InteractionsAKT, AKT3, AND, APC, BRAF, C1Q
KG Connections167 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (8)

CYP46A1 Overexpression Gene Therapy
Score: 0.95
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
RNA Granule Nucleation Site Modulation
Score: 0.66
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66
Nucleolar Stress Response Normalization
Score: 0.65
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65

Related Analyses (4)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (13)

Astrocytes
entity · KG edge: associated_with
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: inhibits
Complement System Dysregulation in Neurodegeneration -
gap · KG edge: activates
AKT3 Gene
gene · KG edge: associated_with
BRAF — B-Raf Proto-Oncogene, Serine/Threonine Kinase
gene · KG edge: associated_with

Knowledge Graph (12 edges)

C1Q activates NRAS
TNF activates NRAS
STAT1 activates NRAS
NRAS activates STAT1
NPM1 associated_with NRAS
TP53 associated_with NRAS
TET2 associated_with NRAS
DNMT3A associated_with NRAS
NRAS associated_with IDH1
NRAS associated_with IDH2

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