concept

MEK

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MEK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

290Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	MEK
Key Genes/Proteins	AGING, Akt, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK
Related Diseases	Aging, Als, ALS, Alzheimer, Amyotrophic Lateral Sclerosis
Related Pathways	Apoptosis

Wiki Pages (9)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    MEK["MEK"]
    style MEK fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    MEK -->|"phosphorylates"| ERK([ERK])
    MEK -.->|"inhibits"| Tumor["Tumor"]
    MEK -.->|"inhibits"| Cancer["Cancer"]
    MEK -.->|"inhibits"| ALS["ALS"]
    MEK -.->|"inhibits"| Senescence["Senescence"]
    MEK -->|"activates"| Aging["Aging"]
    MEK -.->|"inhibits"| Glioblastoma["Glioblastoma"]
    RAF([RAF]) -->|"activates"| MEK
    NST_628{"NST-628"} -.->|"inhibits"| MEK
    Trametinib{"Trametinib"} -.->|"inhibits"| MEK
    __catenin([beta-catenin]) -->|"upstream_of"| MEK
    RAS([RAS]) -->|"activates"| MEK
    TRAMETINIB{"TRAMETINIB"} -.->|"inhibits"| MEK
    KRAS_G12C_inhibitors{"KRAS G12C inhibitors"} -->|"interacts"| MEK
    BRAF([BRAF]) -.->|"inhibits"| MEK
    TARDBP([TARDBP]) -->|"interacts"| MEK

Outgoing (170)

Target	Relation	Type	Str
ERK	activates	protein	0.95
ERK	phosphorylates	protein	0.95
MAPK signaling	participates_in	pathway	0.80
oxidative stress response	participates_in	pathway	0.70
PI3K-AKT-mTOR signaling	participates_in	pathway	0.70
Senescence	therapeutic_target	disease	0.65
ALS	regulates	disease	0.65
Lymphoma	inhibits	disease	0.65
Als	therapeutic_target	disease	0.65
Neurodegeneration	regulates	disease	0.65
Cancer	interacts_with	disease	0.65
Cancer	inhibits	disease	0.65
Alzheimer	regulates	disease	0.65
Cancer	activates	disease	0.65
Aging	inhibits	disease	0.65
Als	regulates	disease	0.65
Aging	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Senescence	inhibits	disease	0.65
Als	inhibits	disease	0.65
ALS	interacts_with	disease	0.65
Cancer	associated_with	disease	0.65
Aging	activates	disease	0.65
Tumor	activates	disease	0.65
Glioblastoma	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Aging	regulates	disease	0.65
Tumor	inhibits	disease	0.65
Senescence	activates	disease	0.65
Lymphoma	therapeutic_target	disease	0.65
RAS	associated_with	gene	0.60
ERK	associated_with	gene	0.60
RAF	regulates	gene	0.60
Mapk	associated_with	pathway	0.60
OLIG2	inhibits	gene	0.60
JAK-STAT signaling	participates_in	pathway	0.60
PKC	activates	gene	0.60
glutamate signaling	participates_in	pathway	0.60
CRISPR-Cas	participates_in	pathway	0.60
XIAP	expressed_in	gene	0.60
synaptic plasticity	participates_in	pathway	0.60
APOPTOSIS	inhibits	gene	0.60
PTPN11	activates	gene	0.60
SRC	expressed_in	gene	0.60
RNA	regulates	gene	0.60
ERK	inhibits	gene	0.60
PCSK9	activates	gene	0.60
JNK	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
Cell Cycle	inhibits	pathway	0.60

Incoming (120)

Source	Relation	Type	Str
RAF	activates	gene	0.95
NST-628	inhibits	drug	0.95
RAF	phosphorylates	protein	0.90
Trametinib	inhibits	drug	0.90
LRRK2	activates	gene	0.90
Binimetinib	inhibits	drug	0.90
β-catenin	upstream_of	protein	0.85
RAS	activates	protein	0.80
TRAMETINIB	inhibits	drug	0.72
KRAS G12C inhibitors	interacts_with	drug	0.72
ERK	disrupts	gene	0.70
BRAF	inhibits	gene	0.65
EZH2	activates	gene	0.60
NRAS	inhibits	gene	0.60
FGFR2	inhibits	gene	0.60
RELB	regulates	gene	0.60
STAT1	regulates	gene	0.60
FOSB	regulates	gene	0.60
RELA	regulates	gene	0.60
TYK2	regulates	gene	0.60
DNA	activates	gene	0.60
GSH	activates	gene	0.60
KRAS	activates	gene	0.60
APC	activates	gene	0.60
PP2A	associated_with	gene	0.60
STAR	inhibits	gene	0.60
JNK	inhibits	gene	0.60
GBM	therapeutic_target	gene	0.60
OVERVIEW	inhibits	gene	0.60
ITGB6	causes	gene	0.60
HER3	causes	gene	0.60
AND	causes	gene	0.60
GDNF	activates	gene	0.60
BAD	inhibits	gene	0.60
AKT	inhibits	gene	0.60
HER2	inhibits	gene	0.60
DR5	inhibits	gene	0.60
EGFR	inhibits	gene	0.60
JUN	inhibits	gene	0.60
C-JUN	inhibits	gene	0.60
AND	inhibits	gene	0.60
AGING	activates	gene	0.60
BMP2	inhibits	gene	0.60
AXL	activates	gene	0.60
ROS	activates	gene	0.60
IRS1	therapeutic_target	gene	0.60
ERK	activates	gene	0.60
OVERVIEW	therapeutic_target	gene	0.60
MTOR	contributes_to	gene	0.60
PI3K	contributes_to	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MEK in their description or question text

No additional research found

MEK

Understanding Entity Pages

Wiki Pages (9)

MEKK3 Protein

MAP2K3 Protein (MEK3)

MEKK2 Protein

MAP3K6 Protein (MEKK6)

MEK2 Protein

MEK1 Protein

MEKK1 Protein

MAP2K1/MEK1 Protein

MAP2K2/MEK2 Protein