gene

CDKN2B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CDKN2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

59Connections

0Hypotheses

0Analyses

33Outgoing

26Incoming

0Experiments

0Debates

Summary

CDKN2B is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, implicated in. Associated with Aging, Cancer, Carcinoma. Connected to 23 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CDKN2B
Full Name	Cyclin-Dependent Kinase Inhibitor 2B (p15/INK4b)
Chromosome	9p21.3
Protein Type	Kinase
Function	p15 binds to and inhibits cyclin-dependent kinases 4 and 6 (CDK4/6), which are required for G1 phase progression.
Pathways	TGF-β, TGF-β signaling
UniProt ID	[P42772](https://www.uniprot.org/uniprot/P42772)
Ensembl ID	ENSG00000147883
OMIM	600431
GeneCards	CDKN2B
Human Protein Atlas	CDKN2B
Associated Diseases	Cancer, Carcinoma, Ms, Senescence, Tumor
Interactions	CANCER, CDKN2B-AS1, C-MYC, CYCLIN D1, LNCRNA, MYC
KG Connections	59 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CDKN2B

gene · 972 words

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Pathway Diagram

graph TD
    CDKN2B["CDKN2B"]
    Carcinoma{"Carcinoma"}
    CDKN2B -->|"associated with"| Carcinoma
    Ms{"Ms"}
    CDKN2B -->|"associated with"| Ms
    Cancer{"Cancer"}
    CDKN2B -->|"associated with"| Cancer
    Tumor{"Tumor"}
    CDKN2B -->|"associated with"| Tumor
    TGFBR1["TGFBR1"]
    CDKN2B -->|"associated with"| TGFBR1
    CANCER["CANCER"]
    CDKN2B -->|"associated with"| CANCER
    BMP2["BMP2"]
    CDKN2B -->|"associated with"| BMP2
    TGFB2["TGFB2"]
    CDKN2B -->|"associated with"| TGFB2
    BMP7["BMP7"]
    CDKN2B -->|"associated with"| BMP7
    neurodegeneration["neurodegeneration"]
    CDKN2B -->|"implicated in"| neurodegeneration
    TGFBR2["TGFBR2"]
    TGFBR2 -->|"associated with"| CDKN2B
    BMP4["BMP4"]
    BMP4 -->|"associated with"| CDKN2B
    MIRNAS["MIRNAS"]
    MIRNAS -->|"associated with"| CDKN2B
    MYC["MYC"]
    MYC -->|"associated with"| CDKN2B
    E2F5["E2F5"]
    E2F5 -->|"associated with"| CDKN2B
    style CDKN2B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (33)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CDKN2B	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
cardiomyocyte degeneration	promotes	phenotype	0.85
Tumor	associated_with	disease	0.85
Carcinoma	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Senescence	associated_with	disease	0.65
Cardiac	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
CANCER	activates	gene	0.60
LNCRNA	activates	gene	0.60
CANCER	associated_with	gene	0.60
BMP2	associated_with	gene	0.60
TGFB2	associated_with	gene	0.60
BMP7	associated_with	gene	0.60
TGFBR1	associated_with	gene	0.60
NRAS	associated_with	gene	0.60
PLCG1	associated_with	gene	0.60
TET2	associated_with	gene	0.60
TP53	associated_with	gene	0.60
U2AF1	associated_with	gene	0.60
Stem Cell	associated_with	pathway	0.60
EIF4E	co_expressed_with	protein	0.50
ENDOG	co_discussed	protein	0.50
MYC	activates	gene	0.50
UBIQUITIN	co_discussed	protein	0.50
NRAS	co_expressed_with	gene	0.50
CYCLIN D1	activates	gene	0.50
RNA	activates	gene	0.50

Incoming (26)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CDKN2B	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
STAT3	activates	protein	0.90
MYC	activates	gene	0.60
CDKN2B-AS1	activates	gene	0.60
STAT3	therapeutic_target	gene	0.60
SIRT2	therapeutic_target	gene	0.60
BMP2	associated_with	gene	0.60
TGFBR1	associated_with	gene	0.60
BMP7	associated_with	gene	0.60
C-MYC	activates	gene	0.60
TGFB2	associated_with	gene	0.60
TGFBR2	associated_with	gene	0.60
BMP4	associated_with	gene	0.60
MYC	associated_with	gene	0.60
E2F5	associated_with	gene	0.60
ATM	associated_with	gene	0.60
CDK6	associated_with	gene	0.60
CDKN2A	associated_with	gene	0.60
MIRNAS	associated_with	gene	0.60
AGING	therapeutic_target	gene	0.60
GENES	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
CDK6	co_expressed_with	gene	0.50
CDKN2A	co_expressed_with	gene	0.50
CANCER	co_discussed	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CDKN2B in their description or question text

No additional research found