concept

PAI1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PAI1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections

0Hypotheses

0Analyses

12Outgoing

7Incoming

0Experiments

0Debates

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💡 Concept Info

Name	PAI1
Key Genes/Proteins	ASTROCYTES, BMAL1, C1Q, COMPLEMENT, GENES, NEURODEGENERATIVE DISORDERS
Related Diseases	Als, Ms
Related Pathways	Complement, Immune Response, Synaptic Plasticity

Pathway Diagram

graph TD
    PAI1["PAI1"]
    PAI1 -->|"activates"| Ms["Ms"]
    PAI1 -->|"inhibits"| Als["Als"]
    PAI1 -->|"inhibits"| PLASMIN["PLASMIN"]
    PAI1 -->|"activates"| TNF["TNF"]
    PAI1 -->|"activates"| STAT1["STAT1"]
    PAI1 -->|"activates"| NRAS["NRAS"]
    PAI1 -->|"activates"| Synaptic_Plasticity["Synaptic Plasticity"]
    PAI1 -->|"activates"| Complement["Complement"]
    BMAL1["BMAL1"] -->|"activates"| PAI1
    C1Q["C1Q"] -->|"activates"| PAI1
    TNF -->|"activates"| PAI1
    NRAS -->|"activates"| PAI1
    GENES["GENES"] -->|"activates"| PAI1
    STAT1 -->|"activates"| PAI1
    COMPLEMENT["COMPLEMENT"] -->|"activates"| PAI1

Outgoing (12)

Target	Relation	Type	Str
Als	inhibits	disease	0.65
Ms	activates	disease	0.65
PLASMIN	inhibits	protein	0.64
NRAS	activates	gene	0.60
Synaptic Plasticity	activates	pathway	0.60
Complement	activates	pathway	0.60
Immune Response	activates	pathway	0.60
ASTROCYTES	activates	gene	0.60
C1Q	activates	gene	0.60
NEURODEGENERATIVE DISORDERS	activates	gene	0.60
TNF	activates	gene	0.60
STAT1	activates	gene	0.60

Incoming (7)

Source	Relation	Type	Str
BMAL1	activates	gene	0.72
C1Q	activates	gene	0.60
TNF	activates	gene	0.60
NRAS	activates	gene	0.60
GENES	activates	gene	0.60
STAT1	activates	gene	0.60
COMPLEMENT	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PAI1 in their description or question text

No additional research found