gene

FGFR2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FGFR2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

147Connections

0Hypotheses

0Analyses

50Outgoing

47Incoming

0Experiments

0Debates

Summary

FGFR2 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, regulates, biomarker for. Associated with Aging, Als, Cancer. Connected to 39 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	FGFR2
Full Name	Fibroblast Growth Factor Receptor 2
Chromosome	10q26
Function	FGFR2 encodes fibroblast growth factor receptor 2, a receptor tyrosine kinase that primarily binds FGF7 and FGF10 (ligands with high specificity for FGFR2IIIb isoform).
Primary Expression	neural progenitors, astrocytes, and some neurons
Pathways	Apoptosis, Chemoresistance, Stem Cell
UniProt ID	[P21802](https://www.uniprot.org/uniprot/P21802)
Ensembl ID	ENSG00000166468
OMIM	176943
GeneCards	FGFR2
Human Protein Atlas	FGFR2
Associated Diseases	Cancer, Cardiac, Ischemia
Interactions	Actin, AND, App, ASTROCYTE, ASTROCYTES, AUTOPHAGY
KG Connections	147 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

FGFR2 — Fibroblast Growth Factor Receptor 2

gene · 540 words

→

Pathway Diagram

graph TD
    FGFR2["FGFR2"]
    Ms{"Ms"}
    FGFR2 -->|"regulates"| Ms
    GFRA1["GFRA1"]
    FGFR2 -->|"regulates"| GFRA1
    Apoptosis(["Apoptosis"])
    FGFR2 -->|"regulates"| Apoptosis
    neurodegeneration["neurodegeneration"]
    FGFR2 -->|"implicated in"| neurodegeneration
    TP53["TP53"]
    TP53 -->|"regulates"| FGFR2
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"regulates"| FGFR2
    style FGFR2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (100)

Target	Relation	Type	Str
Cancer	therapeutic_target	disease	0.85
Carcinoma	therapeutic_target	disease	0.85
MAPK	upstream_of	pathway	0.80
DNA	therapeutic_target	gene	0.70
Parkinson	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Ms	regulates	disease	0.65
Als	therapeutic_target	disease	0.65
Tumor	biomarker_for	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cancer	associated_with	disease	0.65
Aging	inhibits	disease	0.65
Cancer	interacts_with	disease	0.65
Myocardial Infarction	activates	disease	0.65
Cancer	inhibits	disease	0.65
Cardiac	implicated_in	disease	0.65
Aging	regulates	disease	0.65
Als	activates	disease	0.65
Ischemia	implicated_in	disease	0.65
Als	inhibits	disease	0.65
NEUROINFLAMMATION	regulates	phenotype	0.65
ASTROCYTE REACTIVITY	exacerbates	phenotype	0.65
Inflammation	activates	disease	0.65
Chemoresistance	regulates	pathway	0.60
PARKINSON'S DISEASE	activates	gene	0.60
Stem Cell	regulates	pathway	0.60
GFRA1	regulates	gene	0.60
Mek	inhibits	protein	0.60
CANCER	associated_with	gene	0.60
CANCER	therapeutic_target	gene	0.60
EGFR	inhibits	gene	0.60
FGF7	activates	gene	0.60
TP53	inhibits	gene	0.60
Astrocyte Reactivity	associated_with	pathway	0.60
Rb	associated_with	protein	0.60
B3GALT6	activates	gene	0.60
Rb	activates	protein	0.60
Rb	therapeutic_target	protein	0.60
Apoptosis	regulates	pathway	0.60
neurons	expressed_in	cell_type	0.60
YAP	associated_with	gene	0.60
YAP	regulates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
Dopaminergic	activates	cell_type	0.60
Fibroblast	associated_with	cell_type	0.60
Neuron	activates	cell_type	0.60
Astrocyte	activates	cell_type	0.60
Dna Repair	therapeutic_target	pathway	0.60
PTN	activates	gene	0.60
astrocytes	expressed_in	cell_type	0.60

Incoming (47)

Source	Relation	Type	Str
GENES	regulates	gene	0.60
KRAS	biomarker_for	gene	0.60
ASTROCYTES	activates	gene	0.60
FGF	associated_with	gene	0.60
FGFR1	inhibits	gene	0.60
TSC1	inhibits	gene	0.60
PIK3CA	inhibits	gene	0.60
TPR	associated_with	gene	0.60
ESR1	associated_with	gene	0.60
RB1	associated_with	gene	0.60
PCDH15	associated_with	gene	0.60
PIK3CA	therapeutic_target	gene	0.60
BRAF	associated_with	gene	0.60
NRAS	inhibits	gene	0.60
MET	inhibits	gene	0.60
APOPTOSIS	regulates	gene	0.60
FGF1	activates	gene	0.60
DNA	therapeutic_target	gene	0.60
PBRM1	associated_with	gene	0.60
KRAS	therapeutic_target	gene	0.60
DNA	inhibits	gene	0.60
KRAS	regulates	gene	0.60
MEK	inhibits	gene	0.60
MAPK	activates	gene	0.60
TP53	regulates	gene	0.60
CD44	activates	gene	0.60
BRAF	biomarker_for	gene	0.60
NRG1	biomarker_for	gene	0.60
TP53	biomarker_for	gene	0.60
FGFR1	biomarker_for	gene	0.60
CSF1R	activates	gene	0.60
MAPK	inhibits	gene	0.60
CSF1	activates	gene	0.60
KRAS	inhibits	gene	0.60
ASTROCYTE	activates	gene	0.60
GENES	therapeutic_target	gene	0.60
MIRNAS	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
PARKINSON	activates	gene	0.60
FGF	activates	gene	0.60
AND	activates	gene	0.60
IDH1	therapeutic_target	gene	0.60
BRAF	therapeutic_target	gene	0.60
Neuroinflammation	activates	process	0.50
FGF7	activates	gene	0.50
FGF7	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FGFR2 in their description or question text

No additional research found