concept

PTPN11

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PTPN11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

25Connections

0Hypotheses

0Analyses

7Outgoing

18Incoming

0Experiments

0Debates

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💡 Concept Info

Name	PTPN11
Key Genes/Proteins	AKT3, BRAF, BRCA, CD33, DYRK1A, EGFR
Related Pathways	autophagy pathway

Pathway Diagram

graph TD
    PTPN11[PTPN11]
    PTPN11 -.biomarker for.-> Overall_Survival[Overall Survival]
    PTPN11 -->|activates| oncogenic_pathway_activation[oncogenic pathway activation]
    PTPN11 -->|activates| oncogenic_pathway[oncogenic pathway]
    PTPN11 -->|interacts| RHEB[RHEB]
    PTPN11 -->|participates in| autophagy_pathway[autophagy pathway]
    PTPN11 -->|participates in| oxidative_stress_response[oxidative stress response]
    PTPN11 -->|participates in| synaptic_plasticity[synaptic plasticity]
    AKT3[AKT3] -->|interacts| PTPN11
    BRAF[BRAF] -->|interacts| PTPN11
    DYRK1A[DYRK1A] -->|interacts| PTPN11
    EGFR[EGFR] -->|interacts| PTPN11
    FGFR1[FGFR1] -->|interacts| PTPN11
    MTOR[MTOR] -->|interacts| PTPN11
    NF1[NF1] -->|interacts| PTPN11
    NRAS[NRAS] -->|interacts| PTPN11
    PIK3CA[PIK3CA] -->|interacts| PTPN11
    PTEN[PTEN] -->|interacts| PTPN11

Outgoing (7)

Target	Relation	Type	Str
Overall Survival	biomarker_for	phenotype	0.85
oncogenic pathway activation	activates	pathway	0.70
oncogenic pathway	activates	pathway	0.70
oxidative stress response	participates_in	pathway	0.60
synaptic plasticity	participates_in	pathway	0.60
RHEB	interacts_with	gene	0.60
autophagy pathway	participates_in	pathway	0.60

Incoming (18)

Source	Relation	Type	Str
BRCA	associated_with	gene	0.60
HCRTR1	interacts_with	gene	0.60
HCRTR1	activates	gene	0.60
HCRTR2	activates	gene	0.60
NPY4R	activates	gene	0.60
KRAS	interacts_with	gene	0.60
MEK	activates	gene	0.60
CD33	interacts_with	gene	0.60
AKT3	interacts_with	gene	0.60
BRAF	interacts_with	gene	0.60
DYRK1A	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
FGFR1	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
NF1	interacts_with	gene	0.60
NRAS	interacts_with	gene	0.60
PIK3CA	interacts_with	gene	0.60
PTEN	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PTPN11 in their description or question text

No additional research found