| Gene Symbol | MIRO1PROTEIN |
| Target Class | Signaling Protein |
| Function | is a mitochondrial Rho GTPase protein of approximately 71 kDa that plays critical roles in regulating mitochondrial transport, calcium homeostasis, mitochondrial dynamics, and quality control in ne... |
| Mechanism of Action | MIRO1-targeting drugs modulate GTPase activity to enhance mitochondrial transport along axons and improve mitochondrial quality control through selective autophagy. By regulating MIRO1's interaction with kinesin motor proteins and PINK1-mediated mitophagy, these compounds restore energy homeostasis and reduce neuronal stress in neurodegenerative diseases. |
| Subcellular Localization | </strong></td><td>Mitochondrial outer membrane (N-terminus in cytosol)</td></tr> |
| Druggability | Low (0.29) |
| Clinical Stage | Phase II |
| Molecular Weight | 71 kDa |
| GeneCards | MIRO1PROTEIN |
| Human Protein Atlas | MIRO1PROTEIN |
| Associated Diseases | AD, Aging, ALI, Als, Alzheimer |
| Known Drugs/Compounds | Miro-inhibitor-001, GTPASE-mod-42, Mitochondrial transport enhancer XR-789, MIRO1-stabilizing compound MRS-2 |
| Interactions | ABCD3, Actin, ALS, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | Mitochondrial Transfer Pathway Enhancement |
| KG Connections | 1061 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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