gene 2,173 words KG: MCL1
Contents

MCL1 Gene - Myeloid Cell Leukemia 1

🧬 Gene Info
Gene SymbolMCL1
Full NameMyeloid Cell Leukemia 1
Chromosome1q21.2
Functionencodes a critical anti-apoptotic protein of the BCL2 family that plays essential roles in regulating mitochondrial outer membrane permeabilization (MOMP), cellular survival, and mitochondrial dyna...
Molecular Weight37 kDa
Amino Acids350 aa
PathwaysNF-κB
UniProt ID[Q07820](https://www.uniprot.org/uniprot/Q07820)
Ensembl IDENSG00000143384
GeneCardsMCL1
Human Protein AtlasMCL1
Associated DiseasesAD, ALI, Als, Alzheimer, AMI
InteractionsACHE, AD, AND, APOB, APOE, APOPTOSIS
KG Connections350 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (9)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.78
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73

Related Analyses (6)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (10)

Apoptosis in Neurodegeneration
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: regulates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
AGGF1 Gene - Angiogenic Factor
gene · KG edge: upregulates
APOB Gene
gene · KG edge: inhibits

Knowledge Graph (12 edges)

IDH1 therapeutic_target MCL1
VEGFA therapeutic_target MCL1
MDM4 therapeutic_target MCL1
APOB therapeutic_target MCL1
SF3B1 therapeutic_target MCL1
MET therapeutic_target MCL1
SMARCA4 therapeutic_target MCL1
TERT therapeutic_target MCL1
JUN therapeutic_target MCL1
EEF1A1 therapeutic_target MCL1

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