gene

BCL2A1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BCL2A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections

0Hypotheses

0Analyses

16Outgoing

1Incoming

0Experiments

0Debates

Summary

BCL2A1 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, implicated in. Associated with Cancer, Leukemia. Connected to 10 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	BCL2A1
Chromosome	15q24.2
Protein Family	BCL2 family (anti-apoptotic)
Function	BCL2A1 encodes an anti-apoptotic protein that regulates the intrinsic (mitochondrial) apoptosis pathway:
Primary Expression	hematopoietic cells but is also induced in neurons under stress conditions[@bcla2010]
Amino Acids	175 aa
UniProt ID	Q9GZW8
NCBI Gene ID	602
GeneCards	BCL2A1
Human Protein Atlas	BCL2A1
Associated Diseases	neurodegeneration
Interactions	APOPTOSIS, BCL2, CANCER, CASP3, CASP6, CEBPB
KG Connections	17 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: BCL2A1 — AlphaFold Q9GZW8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

BCL2A1 Gene

gene · 676 words

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BCL2A1 Protein

protein · 952 words

→

Pathway Diagram

flowchart TD
    N0["BCL2A1"]
    N1["Cancer"]
    N0 -->|"inhibits"| N1
    N2["Leukemia"]
    N0 -->|"inhibits"| N2
    N3["XIAP"]
    N0 -->|"inhibits"| N3
    N4["BCL2"]
    N0 -->|"inhibits"| N4
    N5["CANCER"]
    N0 -->|"inhibits"| N5
    N6["RBM10"]
    N0 -->|"inhibits"| N6
    N7["Rna Splicing"]
    N0 -->|"inhibits"| N7
    N8["Apoptosis"]
    N0 -->|"inhibits"| N8
    N9["APOPTOSIS"]
    N9 -->|"inhibits"| N0
    N10["neurodegeneration"]
    N0 -->|"implicated in"| N10

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 gene
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 pathway
    class N8 pathway
    class N9 gene

Outgoing (16)

Target	Relation	Type	Str
Cancer	inhibits	disease	0.65
Leukemia	inhibits	disease	0.65
CANCER	inhibits	gene	0.60
Rna Splicing	inhibits	pathway	0.60
Apoptosis	inhibits	pathway	0.60
NF-kB signaling	participates_in	pathway	0.60
XIAP	inhibits	gene	0.60
BCL2	inhibits	gene	0.60
RBM10	inhibits	gene	0.60
CASP3	activates	gene	0.60
CASP6	activates	gene	0.60
CEBPB	activates	gene	0.60
MCL1	activates	gene	0.60
MDM2	activates	gene	0.60
TNF	activates	gene	0.60
oxidative stress response	participates_in	pathway	0.60

Incoming (1)

Source	Relation	Type	Str
APOPTOSIS	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BCL2A1 in their description or question text

No additional research found