gene

BOK

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BOK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

57Connections

0Hypotheses

0Analyses

41Outgoing

16Incoming

0Experiments

0Debates

Summary

Comprehensive information about BOK, a pro-apoptotic BCL2 family protein involved in ER stress-induced apoptosis and implicated in neurodegeneration, Alzheimer's disease, and Parkinson's disease.

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🧬 Gene Info

Gene Symbol	BOK
Full Name	BCL2 Family Ovarian Killer
Chromosome	2q37.3
Function	encodes a pro-apoptotic member of the BCL2 protein family.
Primary Expression	neurons and contributes to apoptosis triggered by ER stress, a common feature of [Alzheimer's disease](/diseases/alzheimer-dise
Molecular Weight	23 kDa
Amino Acids	210 aa
Pathways	Amyloid, Apoptosis, Mitophagy, Parkin-Mediated Mitophagy
UniProt ID	[Q9Y2D6](https://www.uniprot.org/uniprot/Q9Y2D6)
Ensembl ID	ENSG00000165669
GeneCards	BOK
Human Protein Atlas	BOK
Associated Diseases	ALS, Alzheimer
Interactions	APP, MCL1, Parkin, PS1
KG Connections	56 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

BOK — BCL2 Family Ovarian Killer

gene · 2284 words

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Pathway Diagram

graph TD
    BOK["BOK"]
    Parkin["Parkin"]
    BOK -->|"interacts with"| Parkin
    MCL1["MCL1"]
    BOK -->|"interacts with"| MCL1
    mitophagy(["mitophagy"])
    BOK -->|"regulates"| mitophagy
    Alzheimer_s_disease{"Alzheimer's disease"}
    BOK -->|"protects against"| Alzheimer_s_disease
    Alzheimer{"Alzheimer"}
    BOK -->|"regulates"| Alzheimer
    Als{"Als"}
    BOK -->|"regulates"| Als
    Mitophagy(["Mitophagy"])
    BOK -->|"regulates"| Mitophagy
    APP["APP"]
    BOK -->|"associated with"| APP
    ALZHEIMER["ALZHEIMER"]
    BOK -->|"regulates"| ALZHEIMER
    MITOCHONDRIA["MITOCHONDRIA"]
    BOK -->|"regulates"| MITOCHONDRIA
    AND["AND"]
    BOK -->|"regulates"| AND
    AMYLOID["AMYLOID"]
    BOK -->|"regulates"| AMYLOID
    APP -->|"associated with"| BOK
    BCL_2["BCL-2"]
    BCL_2 -->|"associated with"| BOK
    PARKIN["PARKIN"]
    PARKIN -->|"regulates"| BOK
    MCL1 -->|"interacts with"| BOK
    APP_PS1["APP/PS1"]
    APP_PS1 -->|"associated with"| BOK
    NEURON["NEURON"]
    NEURON -->|"associated with"| BOK
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"regulates"| BOK
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"regulates"| BOK
    style BOK fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (41)

Target	Relation	Type	Str
Mitophagy	activates	process	0.95
Parkin-Mediated Mitophagy	regulates	pathway	0.95
Mitochondrial Quality Control	involved_in	process	0.90
MITOPHAGY	promotes	process	0.90
PARKIN	interacts_with	entity	0.85
PRKN	binds	protein	0.85
Parkin	interacts_with	protein	0.85
Cognitive Function	modulates	phenotype	0.85
Alzheimer's Disease	biomarker_for	disease	0.80
mitophagy	regulates	process	0.70
Alzheimer's disease	protects_against	disease	0.70
MCL1	interacts_with	protein	0.70
ALS	regulates	disease	0.65
Lymphoma	regulates	disease	0.65
Cancer	regulates	disease	0.65
Als	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
MCL1	regulates	gene	0.60
Mitophagy	regulates	pathway	0.60
BCL-2	associated_with	gene	0.60
Neuron	associated_with	cell_type	0.60
ALS	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
Alzheimer's disease	interacts_with	disease	0.60
neurons	expressed_in	cell_type	0.60
Alzheimer's disease	regulates	disease	0.60
PS1	interacts_with	gene	0.60
APP	associated_with	gene	0.60
PARKIN	regulates	entity	0.60
MITOPHAGY	regulates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
AMYLOID	regulates	gene	0.60
CANCER	regulates	gene	0.60
BCL-2	regulates	gene	0.60
Apoptosis	regulates	pathway	0.60
NEURON	associated_with	gene	0.60
AND	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
APP/PS1	associated_with	gene	0.60
Amyloid	regulates	pathway	0.60
Neuron	expressed_in	cell_type	0.55

Incoming (16)

Source	Relation	Type	Str
AMYLOID	regulates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
AND	regulates	gene	0.60
BAX	therapeutic_target	gene	0.60
APP	expressed_in	entity	0.60
APP	interacts_with	gene	0.60
APP/PS1	associated_with	gene	0.60
APP	associated_with	gene	0.60
PARKIN	regulates	gene	0.60
MCL1	interacts_with	gene	0.60
BCL-2	associated_with	gene	0.60
NEURON	associated_with	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
MITOPHAGY	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BOK in their description or question text

No additional research found