SciDEX — MAPK SIGNALING

graph TD
    MAPK_SIGNALING["MAPK SIGNALING"]
    MAPK_SIGNALING -->|"regulates"| Hepatocyte_Apoptosis["Hepatocyte Apoptosis"]
    MAPK_SIGNALING -->|"activates"| P38["P38"]
    MAPK_SIGNALING -->|"regulates"| PI3K["PI3K"]
    MAPK_SIGNALING -->|"inhibits"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    MAPK_SIGNALING -->|"activates"| NF_KB["NF-KB"]
    KDEL["KDEL"] -->|"regulates"| MAPK_SIGNALING
    Paeoniflorin["Paeoniflorin"] -->|"modulates"| MAPK_SIGNALING
    ARHGEF2["ARHGEF2"] -->|"activates"| MAPK_SIGNALING
    ATOX1["ATOX1"] -->|"activates"| MAPK_SIGNALING
    lithium["lithium"] -->|"activates"| MAPK_SIGNALING
    AKT["AKT"] -->|"regulates"| MAPK_SIGNALING
    INFLAMMATION["INFLAMMATION"] -->|"activates"| MAPK_SIGNALING
    APOPTOSIS["APOPTOSIS"] -->|"inhibits"| MAPK_SIGNALING

Outgoing (63)

Target	Relation	Type	Str
neural stem cells	active_in	cell_type	0.90
PI3K-AKT-mTOR signaling	crosstalk_with	pathway	0.90
NF-kB signaling	crosstalk_with	pathway	0.90
Hepatocyte Apoptosis	regulates	process	0.89
Prostate Cancer Progression	contributes_to	process	0.85
neurons	active_in	cell_type	0.80
microglia	active_in	cell_type	0.80
astrocytes	active_in	cell_type	0.70
pyroptosis	mediates	process	0.70
unfolded protein response	crosstalk_with	pathway	0.70
P38	activates	gene	0.65
nucleus accumbens	active_in	brain_region	0.60
calcium signaling	mediates	process	0.60
tau phosphorylation	mediates	process	0.60
pyroptosis	crosstalk_with	pathway	0.60
spinal cord	active_in	brain_region	0.60
ER stress	mediates	process	0.60
protein misfolding	mediates	process	0.60
ferroptosis	mediates	process	0.60
white matter	active_in	brain_region	0.60
calcium signaling	crosstalk_with	pathway	0.60
cortex	active_in	brain_region	0.60
dendritic cells	active_in	cell_type	0.60
endothelial cells	active_in	cell_type	0.60
synaptic plasticity	crosstalk_with	pathway	0.60
glymphatic clearance	crosstalk_with	pathway	0.60
ferroptosis	crosstalk_with	pathway	0.60
autophagy pathway	crosstalk_with	pathway	0.60
necroptosis	crosstalk_with	pathway	0.60
NF-KB	inhibits	gene	0.50
BERBERINE	activates	concept	0.50
NEUROINFLAMMATION	inhibits	process	0.50
PI3K	regulates	gene	0.50
NF-KB	activates	gene	0.50
P38	inhibits	gene	0.35
TAU	inhibits	protein	0.35
TAU	activates	protein	0.35
NEURODEGENERATION	biomarker_for	process	0.35
NEUROTOXICITY	biomarker_for	process	0.35
NEUROINFLAMMATION	protects_against	process	0.35
NEUTROPHILS	therapeutic_target	cell_type	0.35
SPINAL CORD INJURY	inhibits	disease	0.35
TOLL-LIKE RECEPTOR SIGNALING	regulates	process	0.35
P38	regulates	gene	0.35
PI3K	therapeutic_target	gene	0.35
PYROPTOSIS	inhibits	process	0.35
RAS	activates	gene	0.35
TNF	inhibits	gene	0.35
TLR4	inhibits	gene	0.35
TNF	regulates	gene	0.35

Incoming (552)

Source	Relation	Type	Str
KDEL	regulates	receptor	0.92
Paeoniflorin	modulates	compound	0.91
Donepezil	inhibits	drug	0.90
neuroinflammation	involves	disease	0.90
ERK	participates_in	gene	0.90
JNK	participates_in	gene	0.90
PI3K-AKT-mTOR Pathway	interacts_with	pathway	0.90
NLRP3	participates_in	gene	0.90
neurodegeneration	involves	disease	0.90
PI3K	participates_in	gene	0.90
MAPK	participates_in	gene	0.90
Alzheimer's disease	involves	disease	0.80
ARHGEF2	activates	gene	0.80
ERK1	participates_in	gene	0.80
MAP	participates_in	gene	0.80
JAK	participates_in	gene	0.80
ALS	participates_in	gene	0.80
TNF	participates_in	gene	0.80
MAPK14	participates_in	gene	0.80
MEK	participates_in	gene	0.80
MAPK3	participates_in	gene	0.80
AKT	participates_in	gene	0.80
ESR1	participates_in	gene	0.80
lithium	activates	drug	0.80
PIK3CA	participates_in	gene	0.80
GSK3	participates_in	gene	0.80
ATOX1	activates	gene	0.80
GSK3B	participates_in	gene	0.80
NLR	participates_in	gene	0.80
AMPK	participates_in	gene	0.80
ERN1	participates_in	gene	0.80
SNCA	participates_in	gene	0.80
ATG	participates_in	gene	0.80
BECN1	participates_in	gene	0.80
microglia	active_in	cell_type	0.75
neurons	active_in	cell_type	0.75
DDIT3	participates_in	gene	0.70
IKK	participates_in	gene	0.70
ATG7	participates_in	gene	0.70
JNK1	participates_in	gene	0.70
P38	participates_in	gene	0.70
CLDN2	participates_in	gene	0.70
EGFR	participates_in	gene	0.70
RB1CC1	participates_in	gene	0.70
JUN	participates_in	gene	0.70
stroke	involves	disease	0.70
NRBF2	participates_in	gene	0.70
BRAF	participates_in	gene	0.70
CALCOCO2	participates_in	gene	0.70
LRP1	participates_in	gene	0.70

Name	MAPK SIGNALING
Key Genes/Proteins	AKT, AKT1, AMPK, APP, CASP3
Related Diseases	AUTISM, cancer, CANCER, Cardiac
Related Pathways	Camp Signaling

MAPK SIGNALING

Understanding Entity Pages

Pathway Diagram

Outgoing (63)

Incoming (552)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Experiments (0)

Related Papers (0)

Debates (0)