gene

PRMT5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRMT5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

163Connections

0Hypotheses

0Analyses

50Outgoing

40Incoming

0Experiments

0Debates

Summary

PRMT5 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, inhibits, activates. Associated with AD, ALS, ARM. Connected to 76 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PRMT5
Full Name	Protein Arginine Methyltransferase 5
Chromosome	14q11.2
Protein Type	Transferase
Function	encodes a type II protein arginine methyltransferase that catalyzes symmetric dimethylation of arginine residues on histones and non-histone substrates.
Pathways	Stem Cell
UniProt ID	O14744
Ensembl ID	ENSG00000100462
OMIM	604045
GeneCards	PRMT5
Human Protein Atlas	PRMT5
Associated Diseases	AD, Als, ARM, brain disorders, BREAST CANCER
Known Drugs/Compounds	PARP inhibitor
Interactions	AND, APOPTOSIS, AUTOPHAGY, CANCER, CDK4, DNA
KG Connections	163 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PRMT5 — AlphaFold O14744 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PRMT5

gene · 1063 words

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Pathway Diagram

graph TD
    PRMT5["PRMT5"]
    Cancer{"Cancer"}
    PRMT5 -->|"therapeutic target"| Cancer
    Cardiovascular{"Cardiovascular"}
    PRMT5 -->|"therapeutic target"| Cardiovascular
    Ms{"Ms"}
    PRMT5 -->|"therapeutic target"| Ms
    Tumor{"Tumor"}
    PRMT5 -->|"therapeutic target"| Tumor
    Als{"Als"}
    PRMT5 -->|"therapeutic target"| Als
    Carcinoma{"Carcinoma"}
    PRMT5 -->|"inhibits"| Carcinoma
    PRMT5 -->|"inhibits"| Ms
    PRMT5 -->|"inhibits"| Cancer
    PRMT5 -->|"inhibits"| Tumor
    PRMT5 -->|"regulates"| Cancer
    PRMT5 -->|"regulates"| Cardiovascular
    ALS{"ALS"}
    PRMT5 -->|"inhibits"| ALS
    PRMT1["PRMT1"]
    PRMT1 -->|"inhibits"| PRMT5
    PRMT1 -->|"therapeutic target"| PRMT5
    FERROPTOSIS["FERROPTOSIS"]
    FERROPTOSIS -->|"inhibits"| PRMT5
    GPX4["GPX4"]
    GPX4 -->|"inhibits"| PRMT5
    CANCER["CANCER"]
    CANCER -->|"inhibits"| PRMT5
    DNA["DNA"]
    DNA -->|"inhibits"| PRMT5
    AND["AND"]
    AND -->|"inhibits"| PRMT5
    DNA -->|"regulates"| PRMT5
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"inhibits"| PRMT5
    PRMT1 -->|"regulates"| PRMT5
    style PRMT5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (123)

Target	Relation	Type	Str
PARP inhibitor	therapeutic_target	drug	0.95
ovarian cancer	therapeutic_target	disease	0.90
Ovarian Cancer	therapeutic_target	disease	0.90
Cancer	targets	disease	0.90
Anti-Cancer Drug Resistance	involved_in	phenotype	0.90
Non-Small Cell Lung Cancer	associated_with	disease	0.90
anti-cancer drug resistance	drives	phenotype	0.90
drug-tolerant cells	promotes	cell_type	0.85
CELL METABOLISM	regulates	entity	0.85
CANCER DRUG RESISTANCE	contributes_to	entity	0.85
SPLICING	regulates	entity	0.85
Breast Cancer	therapeutic_target	disease	0.85
DNA DAMAGE RESPONSE	regulates	entity	0.85
TRANSCRIPTION	regulates	entity	0.85
IMMUNE CELLS	regulates	entity	0.80
AUTOPHAGY	regulates	entity	0.80
DNA DAMAGE REPAIR	regulates	entity	0.80
Non-Small Cell Lung Cancer	biomarker_for	disease	0.80
CARDIOVASCULAR FUNCTION	regulates	entity	0.75
Als	therapeutic_target	disease	0.75
CANCER STEM CELL	regulates	entity	0.75
NEURONAL FUNCTION	regulates	entity	0.75
Cancer	associated_with	disease	0.70
Cancer	activates	disease	0.65
Inflammation	activates	disease	0.65
Cardiovascular	regulates	disease	0.65
Tumor	expressed_in	disease	0.65
Tumor	activates	disease	0.65
Carcinoma	activates	disease	0.65
Cancer	regulates	disease	0.65
ALS	inhibits	disease	0.65
Lung Cancer	activates	disease	0.65
Als	activates	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cancer	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Carcinoma	inhibits	disease	0.65
PRMT1	inhibits	gene	0.60
PRMT1	regulates	gene	0.60
PRMT1	therapeutic_target	gene	0.60
Ferroptosis	inhibits	pathway	0.60
Raf	expressed_in	protein	0.60
Ras	expressed_in	protein	0.60
ALS	associated_with	disease	0.60

Incoming (40)

Source	Relation	Type	Str
PRMT1	associated_with	gene	0.80
PRMT1	interacts_with	gene	0.80
MICRORNAS	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
ITGB6	causes	gene	0.60
HER3	causes	gene	0.60
MEK	causes	gene	0.60
RNA	activates	gene	0.60
CANCER	interacts_with	gene	0.60
KRAS	causes	gene	0.60
RAF	causes	gene	0.60
DNA	inhibits	gene	0.60
KRAS	therapeutic_target	gene	0.60
EXOSOMES	expressed_in	gene	0.60
CANCER	therapeutic_target	gene	0.60
TLR3	therapeutic_target	gene	0.60
RIPK1	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
PRMT1	inhibits	gene	0.60
FUS	associated_with	gene	0.60
FUS	inhibits	gene	0.60
CDK4	inhibits	gene	0.60
DNA	regulates	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
APOPTOSIS	activates	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
ITGB6	therapeutic_target	gene	0.60
GPX4	inhibits	gene	0.60
PRMT1	regulates	gene	0.60
RHOT1	activates	gene	0.60
PRMT4	targets	gene	0.60
FERROPTOSIS	inhibits	gene	0.60
RNA	regulates	gene	0.60
CANCER	inhibits	gene	0.60
HER3	therapeutic_target	gene	0.60
DNA	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
PRMT1	targets	gene	0.60
AND	activates	gene	0.60
RHOT1	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PRMT5 in their description or question text

No additional research found