gene

WEE1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WEE1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

38Connections

0Hypotheses

0Analyses

15Outgoing

23Incoming

0Experiments

0Debates

Summary

WEE1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, inhibits, implicated in. Associated with Cancer, Colorectal Cancer, Tumor. Connected to 14 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	WEE1
Chromosome	11p15.4
Protein Type	Gene
Function	is a nuclear serine/threonine protein kinase that serves as the primary regulator of the G2/M cell cycle checkpoint in mammalian cells[@wee2021].
Subcellular Localization	</strong></td><td>Nucleus</td></tr>
Molecular Weight	70 kDa
Amino Acids	646 aa
GeneCards	WEE1
Human Protein Atlas	WEE1
N-terminal lobe	Contains the ATP-binding pocket with the characteristic VAIK motif in subdomain II
C-terminal lobe	Provides the substrate-binding surface and contains the activation loop
Active site	Located between the two lobes where ATP and substrate bind
Associated Diseases	neurodegeneration
Interactions	CCL5, CD8, CDK2, C-JUN, CXCL10, DDIT3
KG Connections	38 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

WEE1 Protein (WEE1 Kinase)

protein · 2445 words

→

WEE1 Gene

gene · 962 words

→

Pathway Diagram

graph TD
    WEE1["WEE1"]
    Cancer{"Cancer"}
    WEE1 -->|"therapeutic target"| Cancer
    Tumor{"Tumor"}
    WEE1 -->|"inhibits"| Tumor
    CANCER["CANCER"]
    WEE1 -->|"therapeutic target"| CANCER
    SIRT1["SIRT1"]
    WEE1 -->|"inhibits"| SIRT1
    neurodegeneration["neurodegeneration"]
    WEE1 -->|"implicated in"| neurodegeneration
    style WEE1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (15)

Target	Relation	Type	Str
Cancer	therapeutic_target	disease	0.75
CANCER	therapeutic_target	gene	0.70
Tumor	inhibits	disease	0.65
Colorectal Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Checkpoint Inhibitor	therapeutic_target	pathway	0.60
Immune Checkpoint	therapeutic_target	pathway	0.60
Fibroblast	activates	cell_type	0.60
DNA	activates	gene	0.60
KRAS	therapeutic_target	gene	0.60
SIRT1	inhibits	gene	0.60
EGFR	therapeutic_target	gene	0.60
VEGF	therapeutic_target	gene	0.60

Incoming (23)

Source	Relation	Type	Str
C-JUN	activates	gene	0.60
DNA	activates	gene	0.60
IFN	activates	gene	0.60
BRAF	therapeutic_target	gene	0.60
DDIT3	regulates	gene	0.60
FUS	regulates	gene	0.60
DDIT3	activates	gene	0.60
FUS	activates	gene	0.60
DDIT3	expressed_in	gene	0.60
FUS	expressed_in	gene	0.60
CDK2	activates	gene	0.60
CCL5	activates	gene	0.60
CD8	activates	gene	0.60
CXCL10	activates	gene	0.60
IRF3	activates	gene	0.60
STING	activates	gene	0.60
TBK1	activates	gene	0.60
DNA	inhibits	gene	0.60
EFNB3	implicated_in	gene	0.60
EPHB6	implicated_in	gene	0.60
HMGB1	implicated_in	gene	0.60
SLC24A2	implicated_in	gene	0.60
FOXO1	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning WEE1 in their description or question text

No additional research found