concept

IL-17

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL-17: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

582Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	IL-17
Key Genes/Proteins	Actin, Akt, AKT, AKT1, Alpha-Synuclein, ALZHEIMER
Related Diseases	Aging, Als, ALS, Alzheimer
Related Pathways	Amyloid

Pathway Diagram

graph TD
    IL_17["IL-17"]
    IL_17 -->|"mediates"| Myeloid_Cell_Immune_Response["Myeloid Cell Immune Response"]
    IL_17 -->|"mediates"| Neuroinflammation["Neuroinflammation"]
    IL_17 -->|"promotes"| hidradenitis_suppurativa["hidradenitis suppurativa"]
    IL_17 -->|"co_expressed_with"| IL_1["IL-1"]
    IL_17 -.biomarker for.-> Rheumatoid_Arthritis["Rheumatoid Arthritis"]
    IL_17 -->|"activates"| TNF["TNF"]
    IL_17 -->|"inhibits"| IL_6["IL-6"]
    Neutrophils["Neutrophils"] -->|"expressed in"| IL_17
    Microglia["Microglia"] -->|"expressed in"| IL_17
    APOPTOSIS["APOPTOSIS"] -->|"activates"| IL_17
    CYTOKINES["CYTOKINES"] -->|"inhibits"| IL_17
    CASP3["CASP3"] -->|"activates"| IL_17
    ASTROCYTES["ASTROCYTES"] -->|"activates"| IL_17

Outgoing (341)

Target	Relation	Type	Str
Cognitive Impairment	associated_with	phenotype	0.85
Myeloid Cell Immune Response	mediates	process	0.85
hidradenitis suppurativa	promotes	disease	0.85
Neuroinflammation	mediates	process	0.85
Autoimmune Diseases	associated_with	disease	0.80
Rheumatoid Arthritis	biomarker_for	disease	0.80
IL-1	interacts_with	protein	0.80
INFLAMMATION	associated_with	process	0.80
MICROGLIA	upregulates	cell_type	0.80
skeletal muscle inflammation	mediates	process	0.70
Als	transports	disease	0.65
Als	associated_with	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Tumor	inhibits	disease	0.65
Inflammation	activates	disease	0.65
Stroke	expressed_in	disease	0.65
Stroke	therapeutic_target	disease	0.65
ALS	causes	disease	0.65
Als	expressed_in	disease	0.65
Encephalitis	therapeutic_target	disease	0.65
Vascular Dementia	therapeutic_target	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Cirrhosis	activates	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Multiple Sclerosis	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
Als	activates	disease	0.65
Obesity	therapeutic_target	disease	0.65
Hypertension	therapeutic_target	disease	0.65
Ferroptosis	activates	disease	0.65
Anxiety	activates	disease	0.65
Als	regulates	disease	0.65
ALS	inhibits	disease	0.65
Als	inhibits	disease	0.65
Vascular Dementia	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Inflammation	contributes_to	disease	0.65
Ferroptosis	therapeutic_target	disease	0.65
Inflammation	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Aging	activates	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Multiple Sclerosis	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
IL-6	inhibits	gene	0.65

Incoming (241)

Source	Relation	Type	Str
Neutrophils	expressed_in	cell_type	0.85
Microglia	expressed_in	cell_type	0.85
TRIPTOLIDE	inhibits	compound	0.80
blood-brain barrier permeability	activates	process	0.70
IL6	therapeutic_target	gene	0.60
OVERVIEW	activates	gene	0.60
CHI3L1	activates	gene	0.60
CYTOKINES	associated_with	gene	0.60
CD4	activates	gene	0.60
GENES	activates	gene	0.60
S100A8	activates	gene	0.60
S100A9	activates	gene	0.60
PSME3	therapeutic_target	gene	0.60
BAD	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
LAMP2	therapeutic_target	gene	0.60
BID	therapeutic_target	gene	0.60
TLR2	associated_with	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
IL-1	associated_with	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
AMYLOID	activates	gene	0.60
P2RX7	activates	gene	0.60
NAD	activates	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
DEMENTIA	expressed_in	gene	0.60
TNF	causes	gene	0.60
DEMENTIA	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
SOD1	interacts_with	gene	0.60
TNF	contributes_to	gene	0.60
CLDN5	interacts_with	gene	0.60
NATURAL COMPOUNDS	interacts_with	gene	0.60
OXIDATIVE STRESS	interacts_with	gene	0.60
MMP9	interacts_with	gene	0.60
ANXIETY	activates	gene	0.60
TAU	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
TCR	regulates	gene	0.60
RNA	regulates	gene	0.60
AND	inhibits	gene	0.60
APOPTOSIS	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
CXCL1	associated_with	gene	0.60
BAX	activates	gene	0.60
AND	activates	gene	0.60
IL6	therapeutic_target	gene	0.60
APOE	therapeutic_target	gene	0.60
CYP46A1	therapeutic_target	gene	0.60
IL-6	therapeutic_target	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Colonic Th17/IL-17A Axis → Peripheral Immune Recruitment to	0.640	neurodegeneration	What are the mechanisms by which gut mic

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IL-17 in their description or question text

No additional research found