Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BLOOD-BRAIN BARRIER PERMEABILITY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | BLOOD-BRAIN BARRIER PERMEABILITY |
graph TD
BLOOD_BRAIN_BARRIER_PERMEABILI[BLOOD-BRAIN BARRIER PERMEABILITY]
BLOOD_BRAIN_BARRIER_PERMEABILI -->|activates| IL_17[IL-17]
Tight_Junction_Damage[Tight Junction Damage] -->|causes| BLOOD_BRAIN_BARRIER_PERMEABILI
Gut_Dysbiosis[Gut Dysbiosis] -->|causes| BLOOD_BRAIN_BARRIER_PERMEABILI
Tight_Junction[Tight Junction] -->|regulates| BLOOD_BRAIN_BARRIER_PERMEABILI
Adherens_Junction[Adherens Junction] -->|regulates| BLOOD_BRAIN_BARRIER_PERMEABILI
Gap_Junction[Gap Junction] -->|regulates| BLOOD_BRAIN_BARRIER_PERMEABILI
adherens_junction_components[adherens junction components] -->|regulates| BLOOD_BRAIN_BARRIER_PERMEABILI
Dysbiosis[Dysbiosis] -->|causes| BLOOD_BRAIN_BARRIER_PERMEABILI
APOE[APOE] -->|modulates| BLOOD_BRAIN_BARRIER_PERMEABILI
TNF[TNF] -->|activates| BLOOD_BRAIN_BARRIER_PERMEABILI
intestinal_barrier_disruption[intestinal barrier disruption] -->|promotes| BLOOD_BRAIN_BARRIER_PERMEABILI| Target | Relation | Type | Str |
|---|---|---|---|
| sepsis-associated encephalopathy | contributes_to | unknown | 0.85 |
| IL-17 | activates | protein | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Tight Junction Damage | causes | mechanism | 0.93 |
| Compound 1F | associated_with | compound | 0.90 |
| Gut Dysbiosis | causes | phenotype | 0.90 |
| Pg OMVs | associated_with | compound | 0.90 |
| Berbamine hydrochloride | associated_with | compound | 0.90 |
| MIP2 | associated_with | drug | 0.85 |
| adherens junction components | regulates | protein | 0.85 |
| Dysbiosis | causes | disease | 0.85 |
| Tight Junction | regulates | mechanism | 0.85 |
| Adherens Junction | regulates | mechanism | 0.85 |
| Gap Junction | regulates | mechanism | 0.85 |
| oxidative_stress | associated_with | phenotype | 0.75 |
| APOE | modulates | protein | 0.75 |
| TNF | activates | protein | 0.70 |
| intestinal barrier disruption | promotes | process | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| tight-junction remodeling is the actionable driver in: Blood | 0.362 | neurodegeneration | Blood-brain barrier permeability changes |
| endothelial transcytosis defines the therapeutic window for: | 0.357 | neurodegeneration | Blood-brain barrier permeability changes |
| plasma GFAP separates causal from compensatory states in: Bl | 0.346 | neurodegeneration | Blood-brain barrier permeability changes |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Crossing the blood-brain barrier: emerging therapeutic strategies for neurologic [PMID:39862873] | Pedder JH, Sonabend AM, Cearns MD | Lancet Neurol | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| AAV2-driven endothelin induces chronic reduced retinal blood flow/retinal gangli [PMID:40345829] | Shi, Sato, Takahashi, Ohno-Ohishi, Muray | Life science alliance | 2025 | 0 |
| The UNC5C T835M mutation associated with Alzheimer's disease leads to neurodegen [PMID:40468412] | Karunakaran Devi Krishna Priya; Ley Make | Molecular neurodegeneration | 2025 | 0 |
| AAV2-driven endothelin induces chronic reduced retinal blood flow/retinal gangli [PMID:40345829] | Unknown | Life science alliance | 2025 | 0 |
| The UNC5C T835M mutation associated with Alzheimer's disease leads to neurodegen [PMID:40468412] | Karunakaran DKP, Ley M, Guo J, Khatri A, | Molecular neurodegeneration | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Blood-brain barrier biomarkers. [PMID:38797540] | Zapata-Acevedo JF, Mantilla-Galindo A, V | Adv Clin Chem | 2024 | 0 |
| Metformin Mitigates Trimethyltin-Induced Cognition Impairment and Hippocampal Ne [PMID:39441380] | Taheri M, Roghani M, Sedaghat R | Cellular and molecular neurobi | 2024 | 0 |
| Endothelial Cell Senescence Effect on the Blood-Brain Barrier in Stroke and Cogn [PMID:39541552] | Real MGC, Falcione SR, Boghozian R | Neurology | 2024 | 0 |
| Blood-brain barrier biomarkers. [PMID:38797540] | Zapata-Acevedo JF, Mantilla-Galindo A, V | Advances in clinical chemistry | 2024 | 0 |
| Metformin Mitigates Trimethyltin-Induced Cognition Impairment and Hippocampal Ne [PMID:39441380] | Taheri M, Roghani M, Sedaghat R | Cellular and molecular neurobi | 2024 | 0 |
| Endothelial Cell Senescence Effect on the Blood-Brain Barrier in Stroke and Cogn [PMID:39541552] | ["Real Maria Guadalupe C", "Falcione Sar | Neurology | 2024 | 0 |
| Dual-targeting of brain tumors with nanovesicles. [PMID:36816997] | Kianinejad N, Kwon YM | Bioimpacts | 2023 | 0 |
| Post-Ischemic Neurodegeneration of the Hippocampus Resembling Alzheimer's Diseas [PMID:35008731] | Unknown | International journal of molec | 2022 | 0 |
| Post-Ischemic Neurodegeneration of the Hippocampus Resembling Alzheimer's Diseas [PMID:35008731] | Pluta, Januszewski, Czuczwar | International journal of molec | 2022 | 0 |
| Glymphatic system clears extracellular tau and protects from tau aggregation and [PMID:35212707] | Ishida K, Yamada K, Nishiyama R, Hashimo | The Journal of experimental me | 2022 | 0 |
| Glymphatic system clears extracellular tau and protects from tau aggregation and [PMID:35212707] | Ishida K, Yamada K, Nishiyama R, Hashimo | The Journal of experimental me | 2022 | 0 |
| Peripheral inflammation and blood-brain barrier disruption: effects and mechanis [PMID:33381913] | Huang X, Hussain B, Chang J | CNS Neurosci Ther | 2021 | 0 |
| Strategies for delivering therapeutics across the blood-brain barrier. [PMID:33649582] | Terstappen GC, Meyer AH, Bell RD | Nat Rev Drug Discov | 2021 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning BLOOD-BRAIN BARRIER PERMEABILITY in their description or question text
No additional research found