protein

NSF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NSF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

109Connections
8Hypotheses
0Analyses
50Outgoing
39Incoming
20Experiments
0Debates

Summary

NSF is a protein involved in neurodegeneration research. Key relationships include: associated with, regulates, interacts with. Associated with Als, Cancer, Glioma. Connected to 54 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolNSF
Full NameN-Ethylmaleimide Sensitive Fusion Protein
Chromosome17q21.31
FunctionNSF is a member of the AAA+ (ATPases Associated with diverse cellular Activities) protein family that functions as a molecular chaperone for SNARE complex recycling
Primary Expressionall eukaryotic cells, with high expression in neurons - Protein Complexes: Forms hexameric complexes and interacts with alpha
Molecular Weight66 kDa
PathwaysApoptosis, Cell Cycle
UniProt IDP46459
NCBI Gene ID4900
Ensembl IDENSG00000134574
OMIM163580
GeneCardsNSF
Human Protein AtlasNSF
Associated Diseasesepilepsy
Known Drugs/Compoundsrapamycin
InteractionsAMPK, AND, LC3, MAP1LC3, MTOR, MTORC1
KG Connections109 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: NSF — AlphaFold P46459 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

NSF Gene

gene · 612 words

NAPA — NSF Attachment Protein Alpha

gene · 993 words

NSF Protein

protein · 953 words

alpha-SNAP Protein (NSF Attachment Protein Alpha)

protein · 635 words

Pathway Diagram

graph TD
    NSF["NSF"]
    Cancer{"Cancer"}
    NSF -->|"regulates"| Cancer
    Tumor{"Tumor"}
    NSF -->|"regulates"| Tumor
    Glioma{"Glioma"}
    NSF -->|"regulates"| Glioma
    Als{"Als"}
    NSF -->|"regulates"| Als
    Ms{"Ms"}
    NSF -->|"regulates"| Ms
    Stroke{"Stroke"}
    NSF -->|"interacts with"| Stroke
    LAMP1["LAMP1"]
    NSF -->|"associated with"| LAMP1
    ATG12["ATG12"]
    NSF -->|"associated with"| ATG12
    Mtor(["Mtor"])
    NSF -->|"associated with"| Mtor
    Autophagy(["Autophagy"])
    NSF -->|"associated with"| Autophagy
    GAPDH["GAPDH"]
    NSF -->|"associated with"| GAPDH
    STX17["STX17"]
    NSF -->|"associated with"| STX17
    VAMP8["VAMP8"]
    VAMP8 -->|"associated with"| NSF
    ULK1["ULK1"]
    ULK1 -->|"associated with"| NSF
    LC3["LC3"]
    LC3 -->|"associated with"| NSF
    MCOLN1["MCOLN1"]
    MCOLN1 -->|"associated with"| NSF
    GAPDH -->|"associated with"| NSF
    STX17 -->|"associated with"| NSF
    SQSTM1["SQSTM1"]
    SQSTM1 -->|"associated with"| NSF
    MAP1LC3["MAP1LC3"]
    MAP1LC3 -->|"associated with"| NSF
    P62["P62"]
    P62 -->|"associated with"| NSF
    ATG12 -->|"associated with"| NSF
    STX17 -->|"contributes to"| NSF
    MIRNAS["MIRNAS"]
    MIRNAS -->|"regulates"| NSF
    style NSF fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (70)

TargetRelationTypeStr
SNCAexpressesgene0.70
Gliomaregulatesdisease0.65
Alsbiomarker_fordisease0.65
Cancerregulatesdisease0.65
Tumorregulatesdisease0.65

Incoming (39)

SourceRelationTypeStr
KEAP1expressesgene0.70
AUTOPHAGYregulatespathway0.60
STX17associated_withgene0.60
ATG12associated_withgene0.60
ATG12activatesentity0.60

Targeting Hypotheses (8)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
pH-Sensitive Bispecific Antibody Targeting Transferrin Recep 0.800 neurodegeneration Blood-brain barrier antibody transport m
Magnetosonic-Triggered Transferrin Receptor Clustering 0.719 neurodegeneration Blood-brain barrier transport mechanisms
Mitochondrial Transfer Pathway Enhancement 0.695 neurodegeneration Astrocyte reactivity subtypes in neurode
CX43 hemichannel engineering enables size-selective mitochon 0.686 neurodegeneration Mitochondrial transfer between astrocyte
GAP43-mediated tunneling nanotube stabilization enhances neu 0.666 neurodegeneration Mitochondrial transfer between astrocyte
Extracellular Vesicle Cargo Transfer 0.480 neurodegeneration Which specific factors in conditioned me
Optogenetic Control of Mitochondrial Transfer Networks 0.476 neurodegeneration Mitochondrial transfer between neurons a
Transferrin-Alectinib Conjugation Enhances Blood-Brain Barri 0.406 molecular biology Does Alectinib truly bind C1q directly w

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (20)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
Autophagy receptor identification for stress granule elimination exploratory neurodegenerative diseases 0.900 0.00 cultured cells under arsenite proposed N/A
iPSC-derived endothelial cell iron uptake with RLS CSF exposure exploratory restless legs syndrome 0.900 0.00 iPSC-derived human endothelial proposed N/A
Cx43 knockdown effects on mitochondrial transfer exploratory osteoarthritis 0.900 0.00 human bone marrow-derived MSCs proposed N/A
Confocal imaging of MSC-chondrocyte interactions during mitochondrial exploratory osteoarthritis 0.850 0.00 human bone marrow-derived MSCs proposed N/A
Auditory nerve responses to combined optogenetic and electrical stimul validation sensorineural hearing loss/dea 0.850 0.00 transgenic mice expressing ChR proposed N/A
s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice with engin falsification Neuroinflammation 0.400 0.50 mouse proposed $200,000
s:** - Compare uptake with/without magnetic particles using tight junc falsification Neurodegeneration 0.400 0.50 cell_line proposed $120,000
AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Therapy validation Parkinson's Disease 0.400 0.50 mouse proposed $280,000
AAV Serotype Comparison for LRRK2 Knockdown in PD validation Parkinson's Disease 0.400 0.50 mouse proposed $280,000
s:** - Test MCU overexpression specifically in layer II neurons in hea falsification Neurodegeneration 0.400 0.50 mouse proposed $200,000
Proposed experiment from debate on Mitochondrial transfer between astr falsification Neurodegeneration 0.400 0.50 cell_line proposed $80,000
Proposed experiment from debate on Mitochondrial transfer between astr falsification Neurodegeneration 0.400 0.50 cell_line proposed $100,000
Mechanism: Selective Vulnerability of Dopaminergic Neurons in Parkinso validation Parkinson's Disease 0.400 0.50 human proposed $3,000,000
Selective Vulnerability of Dopaminergic Neurons — Mechanism and Protec validation Neurodegeneration 0.400 0.50 cell_line proposed $160,000
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment Design clinical Parkinson's Disease 0.400 0.50 human proposed $7,500,000
Exercise-BDNF-Mitophagy Biomarker Study in PD clinical Parkinson's Disease 0.400 0.50 human proposed $6,550,000
Ferroptosis Validation in Parkinson's Disease clinical Parkinson's Disease 0.400 0.50 human proposed $6,550,000
GLP-1 Agonist Neuroprotection Mechanism in PD clinical Parkinson's Disease 0.400 0.50 human proposed $6,550,000
Cytochrome Therapeutics clinical Parkinson's Disease 0.400 0.50 human proposed $5,460,000
AAV-LRRK2 IND-Enabling Study Design clinical Parkinson's Disease 0.400 0.50 human proposed $7,500,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Enhancer AAVs for targeting spinal motor neurons and descending motor pathways i [PMID:40403722] Emily Kussick, Nelson Johansen, Naz Task Cell Reports 2025 19
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic t [PMID:32048886] Yao RQ, Ren C, Xia ZF, Yao YM Autophagy 2021 2
Astrocytic Connexin43 in Alzheimer's disease: mechanisms, interaction with P2 re [PMID:41062060] Xiong W, Su Y, Verkhratsky A, Yi C Neuropharmacology 2026 1
Miro1: A potential target for treating neurological disorders. [PMID:40403957] Zeng L, Yang J, Zhang C, Zhu J, Zhong S, Neuroscience 2025 1
Connexin43 hemichannel blockade turns microglia neuroprotective and mitigates co [PMID:40595567] Su Y, Li H, Zhang W, Tao S, Wang Q, Zhan Nat Commun 2025 1
Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease. [PMID:40425446] Sehlin D, Hultqvist G, Michno W, Aguilar J Prev Alzheimers Dis 2025 1
Calcium-Associated Proteins in Neuroregeneration. [PMID:38397420] Lisek M, Tomczak J, Boczek T, Zylinska L Biomolecules 2024 1
Should it stay or should it go: gap junction protein GJA1/Cx43 conveys damaged l [PMID:39394955] Domingues N, Ribeiro-Rodrigues T, Girão Autophagy 2024 1
Connexin 43 regulates intercellular mitochondrial transfer from human mesenchyma [PMID:39390589] Irwin RM, Thomas MA, Fahey MJ, Mayán MD, Stem Cell Res Ther 2024 1
Mitochondria from osteolineage cells regulate myeloid cell-mediated bone resorpt [PMID:38877020] Ding P, Gao C, Zhou J, Mei J, Li G, Liu Nat Commun 2024 1
Effect of ferroptosis on chronic cerebral hypoperfusion in vascular dementia. [PMID:37709116] Fu P, Chen Y, Wu M, Bao B, Yin X, Chen Z Exp Neurol 2023 1
Selective inhibition of cannabinoid CB(1) receptor-evoked signalling by the inte [PMID:37689260] Maroto IB, Moreno E, Costas-Insua C, Mer Neuropharmacology 2023 1
lncRNA LOC100911717-targeting GAP43-mediated sympathetic remodeling after myocar [PMID:36684596] Li P, Wang K, Yin J, Qi L, Hu H, Yang P, Front Cardiovasc Med 2022 1
Machine Learning and Novel Biomarkers for the Diagnosis of Alzheimer's Disease. [PMID:33803217] Chang CH, Lin CH, Lane HY Int J Mol Sci 2021 1
Astrocyte Networks as Therapeutic Targets in Glaucomatous Neurodegeneration. [PMID:34199470] Boal AM, Risner ML, Cooper ML, Wareham L Cells 2021 1
On Iron Metabolism and Its Regulation. [PMID:33925597] Vogt AS, Arsiwala T, Mohsen M, Vogel M, Int J Mol Sci 2021 1
MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote qualit [PMID:34873283] König T, Nolte H, Aaltonen MJ, Tatsuta T Nat Cell Biol 2021 1
Transferrin Receptor Is a Specific Ferroptosis Marker. [PMID:32160546] Feng H, Schorpp K, Jin J, Yozwiak CE, Ho Cell Rep 2020 1
Transferrin and transferrin receptors update. [PMID:29969719] Kawabata H Free Radic Biol Med 2019 1
Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal ste [PMID:24431222] Ahmad T, Mukherjee S, Pattnaik B, Kumar EMBO J 2014 1

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NSF in their description or question text

Extracellular Vesicle Cargo Transfer

Score: 0.480 · neurodegeneration · 2026-04-25

Healthy astrocytes release EVs containing protective cargo (potentially protein or RNA) that modifies recipient motor ne

Optogenetic Control of Mitochondrial Transfer Networks

Score: 0.476 · neurodegeneration · 2026-04-02

Light-activated ion channels in astrocytes trigger calcium influx that stimulates tunneling nanotube formation and mitoc

Transferrin-Alectinib Conjugation Enhances Blood-Brain Barrier Transport via Tra

Score: 0.406 · molecular biology · 2026-04-21

## Mechanistic Overview Transferrin-Alectinib Conjugation Enhances Blood-Brain Barrier Transport via Transferrin Recepto